| Title: | Clinical significance of histologic subtyping of malignant pleural mesothelioma |
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| Authors: | Brčić, Luka (Author)
Kern, Izidor (Author) |
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| Language: | English |
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| Tipology: | 1.02 - Review Article |
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| Organisation: |  UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik |
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| Abstract: | Malignant mesothelioma (MM) is uncommon, but very aggressive tumor arising from the mesothelial cells of pleura, pericardium, peritoneum, and tunica vaginalis. Despite multimodality treatments 5-year survival is only 5% after the diagnosis. Histology and TNM staging system are still the best prognostic factors. Furthermore, histologic subtype of MM determines the clinical management of the patients. According to the 2015 WHO classification, MM is divided into diffuse, localized and well differentiated papillary mesothelioma. Major histologic subtypes of diffuse MM, namely epithelioid, biphasic and sarcomatoid, have different prognosis. However, in the last decade it has become evident that more detailed subclassification and histologic/cytological characterization of MM have prognostic and perhaps predictive implications. In this review, major histologic subtypes and cytological features of MM are presented and their relation with prognosis and predictive biomarkers is discussed. |
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| Keywords: | malignant mesothelioma, epithelioid malignant mesothelioma, biphasic malignant mesothelioma, sarcomatoid malignant mesothelioma |
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| Year of publishing: | 2020 |
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| Publisher: | AME Publishing Company |
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| Source: | Hong Kong |
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| COBISS_ID: | 17124867  |
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| UDC: | 616-006 |
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| ISSN on article: | 2226-4477 |
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| OceCobissID: | 17120003 |
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| DOI: | 10.21037/tlcr.2020.03.38 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 27. 5. 2020;
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| Views: | 1317 |
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| Downloads: | 711 |
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| Files: |  PDF - Presentation file, download (1,86 MB)
 URL - Source URL, visit http://tlcr.amegroups.com/article/view/38662/pdf
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| | | Journal: | Transl. lung cancer res.
Pioneer Bioscience
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| | | Metadata: |     |
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| Rights: | Translational lung cancer research |
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