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Title:Clinical significance of histologic subtyping of malignant pleural mesothelioma
Authors:Brčić, Luka (Author)
Kern, Izidor (Author)
Language:English
Tipology:1.02 - Review Article
Organisation:Logo UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
Abstract: Malignant mesothelioma (MM) is uncommon, but very aggressive tumor arising from the mesothelial cells of pleura, pericardium, peritoneum, and tunica vaginalis. Despite multimodality treatments 5-year survival is only 5% after the diagnosis. Histology and TNM staging system are still the best prognostic factors. Furthermore, histologic subtype of MM determines the clinical management of the patients. According to the 2015 WHO classification, MM is divided into diffuse, localized and well differentiated papillary mesothelioma. Major histologic subtypes of diffuse MM, namely epithelioid, biphasic and sarcomatoid, have different prognosis. However, in the last decade it has become evident that more detailed subclassification and histologic/cytological characterization of MM have prognostic and perhaps predictive implications. In this review, major histologic subtypes and cytological features of MM are presented and their relation with prognosis and predictive biomarkers is discussed.
Keywords:malignant mesothelioma, epithelioid malignant mesothelioma, biphasic malignant mesothelioma, sarcomatoid malignant mesothelioma
Year of publishing:2020
Publisher:AME Publishing Company
Source:Hong Kong
COBISS_ID:17124867 Link is opened in a new window
UDC:616-006
ISSN on article:2226-4477
OceCobissID:17120003 Link is opened in a new window
DOI:10.21037/tlcr.2020.03.38 Link is opened in a new window
Note:Nasl. z nasl. zaslona; Opis vira z dne 27. 5. 2020;
Views:1317
Downloads:711
Files:.pdf PDF - Presentation file, download (1,86 MB)
URL URL - Source URL, visit http://tlcr.amegroups.com/article/view/38662/pdf
 
Journal:Transl. lung cancer res.
Pioneer Bioscience
 
Metadata:XML RDF-CHPDL DC-XML DC-RDF
Rights:Translational lung cancer research
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License:CC BY-NC-ND 4.0, Creative Commons Attribution Non-Commercial No Derivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:22.06.2020

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