| Title: | Clinical significance of histologic subtyping of malignant pleural mesothelioma |
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| Authors: | ID Brčić, Luka (Author)
ID Kern, Izidor, Klinika Golnik (Author) |
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| Files: |  PDF - Presentation file, download (1,86 MB)
MD5: 7FB5E9D004DA51FE3C51F4D3271B9B52
 URL - Source URL, visit http://tlcr.amegroups.com/article/view/38662/pdf
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| Language: | English |
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| Typology: | 1.02 - Review Article |
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| Organization: |  UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
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| Abstract: | Malignant mesothelioma (MM) is uncommon, but very aggressive tumor arising from the mesothelial cells of pleura, pericardium, peritoneum, and tunica vaginalis. Despite multimodality treatments 5-year survival is only 5% after the diagnosis. Histology and TNM staging system are still the best prognostic factors. Furthermore, histologic subtype of MM determines the clinical management of the patients. According to the 2015 WHO classification, MM is divided into diffuse, localized and well differentiated papillary mesothelioma. Major histologic subtypes of diffuse MM, namely epithelioid, biphasic and sarcomatoid, have different prognosis. However, in the last decade it has become evident that more detailed subclassification and histologic/cytological characterization of MM have prognostic and perhaps predictive implications. In this review, major histologic subtypes and cytological features of MM are presented and their relation with prognosis and predictive biomarkers is discussed. |
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| Keywords: | malignant mesothelioma, epithelioid malignant mesothelioma, biphasic malignant mesothelioma, sarcomatoid malignant mesothelioma |
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| Publication status: | In print |
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| Publication version: | Author Accepted Manuscript |
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| Place of publishing: | Hong Kong |
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| Publisher: | AME Publishing Company |
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| Year of publishing: | 2020 |
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| Number of pages: | str.1-10 |
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| Numbering: | Vol. 9, iss. |
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| PID: | 20.500.12556/DiRROS-12161  |
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| UDC: | 616-006 |
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| ISSN on article: | 2226-4477 |
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| DOI: | 10.21037/tlcr.2020.03.38 |
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| COBISS.SI-ID: | 17124867 |
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| Copyright: | Translational lung cancer research |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 27. 5. 2020;
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| Publication date in DiRROS: | 22.06.2020 |
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| Views: | 2204 |
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| Downloads: | 1182 |
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