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Title:Postiradiacijska morfea - redek pozni zaplet obsevanja po ohranitveni operaciji raka dojk
Authors:Ratoša, Ivica (Author)
Blatnik, Olga (Author)
Koren Krajnc, Metka (Author)
Language:Slovenian
Tipology:1.04 - Professional Article
Organisation:Logo OI - Institute of Oncology
Abstract:V prispevku opisujemo primer bolnice z lokalizirano morfeo ali sklerodermo (angl. post-irradiation morphea, PIM), ki je redek in slabo prepoznan pozni zaplet obsevanja. Najpogosteje se pojavi po obsevanju dojke. PIM se pojavi po obdobju brez težav, ki lahko traja od nekaj mesecev do več let. Etiopatogeneza ni pojasnjena. Diagnozo lahko postavimo šele, ko smo izključili druge bolezni, ki jo lahko posnemajo. Diferencialno diagnostično v poštev prihaja vnetni rak dojk, okužbe (predvsem v zgodnji fazi PIM), limfedem, druge dermatološke ali avtoimune bolezni ter postiradiacijska fibroza. Za izključitev ostalih bolezni so potrebni natančna anamneza, ustrezne slikovne in laboratorijske preiskave in biopsija prizadetega mesta, s katero lahko, ob ustrezni klinični sliki, diagnozo morfee tudi potrdimo. Zdravljenje PIM je najbolj uspešno, če bolezen pravočasno prepoznamo še v akutni fazi, ko lahko upočasnimo ali ustavimo prehod v fibrozo in tako preprečimo slab kozmetski rezultat lokalnega zdravljenja dojke.
Keywords:rak dojk, z obsevanjem povzročena morfea, obsevanje, radioterapija
Year of publishing:2019
COBISS_ID:3414651 Link is opened in a new window
UDC:615.82/.84
ISSN on article:1408-1741
OceCobissID:65324032 Link is opened in a new window
DOI:10.25670/oi2019-018on Link is opened in a new window
Views:1559
Downloads:496
Files:.pdf PDF - Presentation file, download (162,64 KB)
 
Journal:Onkologija
Onkološki inštitut
 
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Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:13.01.2020

Secondary language

Language:English
Title:Radiation-induced morphea - a rare late effect of adjuvant radiation therapy following breast conserving surgery
Abstract:We present a case report of radiation-induced morphea (PIM) or circumscribed localized scleroderma that most often occurs following radiation therapy of the breast. PIM is a rare and underrecognized local side-effect of radiation therapy. Typically, the symptoms of PIM manifest following a variable period of asymptomatic latency, lasting from few months to few years. The etiopathogenesis is unclear. PIM is a clinical diagnosis of exclusion. Differential diagnoses include inflammatory breast cancer, cellulitis or mastitis, breast lymphedema, other dermatological or autoimmune disorders and post-irradiation fibrosis. Careful patient assessment with thorough medical history, physical examination, laboratory tests and surgical biopsy of the affected area is needed to confirm PIM. Early recognition of the acute inflammatory phase is crucial to subsequent disease management in order to prevent late irreversible fibrosis and poor cosmetic outcome of the treated breast.


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