1. Immunotoxin - a new treatment option in patients with relapsed and refractory Hodgkin lymphomaBarbara Jezeršek Novaković, 2015, review article Abstract: Background. Even though Hodgkin lymphoma is a highly curable disease, some of the patients have either a refractory disease or experience a relapse following a successful primary therapy. Durable responses and remissions in patients with relapsed or refractory disease may be achieved in approximately one-half with salvage chemotherapy followed by high dose chemotherapy (HDT) and autologous hematopoietic cell rescue (SCT). On the other hand, patients who relapse after HDT and autologous SCT or those who have failed at least two prior multi-agent chemotherapy regimens and are not candidates for HDT have limited treatment options. Conclusions. A new treatment option in this population is an immunotoxin Brentuximab vedotin composed of a CD30 directed antibody linked to the antitubulin agent monomethyl auristatin E. It has demonstrated a substantial effectiveness and an acceptable toxicity. In the pivotal study, the overall response rate was 75% with 34% of complete remissions. The median durations of response were 20.5 and 6.7 months for those with complete remission and all responding patients, respectively. The median overall survival was 40.5 months (3-years overall survival 54%) and the median progression-free survival 9.3 months. The most common non-hematologic toxicities were peripheral sensory neuropathy, nausea, and fatigue while the most common severe side effects were neutropenia, thrombocytopenia, anemia, and peripheral sensory neuropathy. Keywords: immunotoxin, Hodgkin lymphoma, toxicity, new treatment option Published in DiRROS: 22.04.2024; Views: 351; Downloads: 377 Full text (520,10 KB) |
2. Results of postoperative radiochemotherapy of the patients with resectable gastroesophageal junction adenocarcinoma in SloveniaAna Jeromen, Irena Oblak, Franc Anderluh, Vaneja Velenik, Marija Skoblar Vidmar, Ivica Ratoša, 2012, original scientific article Keywords: gastroesophageal junction adenocarcinoma, postoperative radiochemotherapy, toxicity Published in DiRROS: 21.03.2024; Views: 146; Downloads: 37 Full text (419,66 KB) |
3. Degradation and Stabilization of Polymer MaterialsBranka Mušič, Andrijana Sever Škapin, 2023, other scientific articles Keywords: polymer-based materials, nano, micro, and macro composites, effects on (micro) organisms and toxicity, impact on the ecosystem, mechanisms and products of accelerated aging and degradation, physical, chemical, mechanical, thermal, and morphological, analysis, biodegradability, sustainability, life cycle, renewable and recycled resources and the circular economy Published in DiRROS: 21.12.2023; Views: 287; Downloads: 99 Full text (226,05 KB) This document has many files! More... |
4. Stability and toxicity of selected chlorinated benzophenone-type UV filters in watersRomina Žabar, Darko Dolenc, Polonca Trebše, Tatjana Tišler, Gorica Grbović, Jun Yao, Rensheng Zhuang, 2013, original scientific article Abstract: Stability and toxicity of selected chlorinated benzophenone-type UV filters in waters Keywords: UV filter, photostability, chlorination, toxicity, Vibrio fischeri Published in DiRROS: 16.03.2016; Views: 3895; Downloads: 512 Link to full text |