1. Access to kidney transplantation and re-transplantation from childhood to adulthood : long-term data from the ERA RegistryEvgenia Preka, Marjolein Bonthuis, Stephen D Marks, Anneke Kramer, Aiko P J De Vries, Søren S. Sørensen, Sevcan A. Bakkaloglu, Claus Bistrup, Olga L Rodríguez Arévalo, Miha Arnol, Timo Jahnukainen, 2025, original scientific article Abstract: Background and hypothesis: Knowledge regarding access to first kidney transplantation (KT) and subsequent KT in patients commencing kidney replacement therapy (KRT) in childhood is limited. Methods: Using European Renal Association (ERA) Registry data, we investigated European patients who started KRT below 20 years of age between 1978 and 2019. Access and determinants to first, second, and third KT were assessed using multivariable Cox regression. Results: Totals of 12 623, 4077, and 1186 patients were included while awaiting first, second, and third KT, at median ages of 13.8 (IQR: 7.5–17.4), 20.9 (IQR: 16.5–26.1), and 26.6 (IQR: 20.3–32.8) years, respectively. During the study period, overall access was 87.8%, 72.7%, and 60.5% for first, second, and third KT, respectively, and median time to each KT was 0.9 (IQR: 0.2–2.1), 1.9 (0.6–4.5), and 2.6 (IQR: 1.0–5.3) years. Younger age at KRT initiation (aHR 0-4 vs. 10–14 years: 0.54; 95%CI: 0.51–0.57) and female sex (HR: 0.94; 95%CI: 0.90–0.98) were associated with lower access to first KT. KT candidates between 15 and 19 years had lower access to first and second KT (aHR: 0.69; 95%CI: 0.66–0.73, and aHR: 0.70; 95%CI: 0.61–0.81) compared to 10–14 year-olds. Compared to CAKUT, glomerulonephritis patients had lower access to KT (aHR: 0.75; 95%CI: 0.71–0.80 for first, aHR: 0.89; 95%CI: 0.81–0.98 for second, and aHR: 0.80; 95%CI: 0.66–0.97 for third KT). Similarly, patients with primary renal diseases with high risk of recurrence, had lower chances of receiving a first and second KT (aHR: 0.80; 95%CI: 0.76–0.85 for first, aHR: 0.86; 95%CI: 0.78–0.95 for second KT). Access to re-transplantation was also higher with previous pre-emptive KT and previous graft survival exceeding 5 years. Conclusion: Our study highlights KT access disparities particularly for females, the youngest recipients, high-risk age (15–19 years), and diseases with recurrence risk. Notably, pre-emptive transplants and enduring previous grafts offer advantages regarding retransplantation.
Keywords: presaditev ledvice, ponovna presaditev ledvice, otroci, adolescenti
Published in DiRROS: 27.02.2026; Views: 72; Downloads: 26
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5. Ultrazvočno vodena aspiracijska biopsija s tanko iglo v diagnostiki ledvičnih tumorjevMargareta Strojan Fležar, Bojana Černelč, Helena Gutnik, Alenka Višnar-Perovič, 2011, professional article Abstract: Ultrazvočno vodena aspiracijska biopsija je v Sloveniji že dolga leta standardna metoda za morfološko diagnostiko radiološko težavnih ledvičnih tumorjev. V zadnjih letih se zanimanje za to diagnostično metodo povečuje tudi v Evropi, predvsem za dodatno diagnostiko majhnih tumorjev, ki merijo največ 3 cm. V naši analizi smo potrdili, da je metoda uporabna za diagnostiko majhnih tumorjev, če so vzorci dovolj celularni in reprezentativni za lezijo. V citopatološki diagnostiki so nam v pomoč tudi imunocitokemična barvanja, s katerimi lahko natančneje opredelimo tip ledvičnega karcinoma: svetlocelični, papilarni in kromofobni karcinom ledvičnih celic.
Keywords: ledvice, tumor, karcinom, diagnostika, aspiracijska biopsija
Published in DiRROS: 31.08.2018; Views: 4407; Downloads: 1230
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