241. Elektrokemoterapija : učinki na žilje tumorjaGregor Serša, Maja Čemažar, Marko Snoj, 2008, professional article Abstract: Terapevtska učinkovitost zdravljenj, ki delujejo na žilje tumorja, je sedaj splošno priznana. Odkrivajo se vedno nova zdravila in pristopi, ki ciljajo žilje tumorja, zato jih imenujemo žilno ciljano zdravljenje (vascular targeted therapies). Poznamo dve vrsti tega zdravljenja, in sicer antiangiogeno (anti-angiogenic therapies) in žilno razdiralno (vascular-disrupting therapies). Ločita se po fizioloških tarčah, primernosti za zdravljenje glede na obseg bolezni in režimu zdravljenja. Zadnja odkritja kažejo, da ima elektrokemoterapija poleg neposrednega citotoksičnega delovanja tudi žilno razdiralni učinek, ker na endotelne celice tumorskega žilja deluje citotoksično. Zaradi odmiranja teh celic prihaja do trajnih ustavitev pretoka krvi in do ishemičnega propada tumorskih celic v poškodovanih delih tumorja. Zaradi žilno razdiralnega učinka je elektrokemoterapija učinkovita tudi pri zdravljenju krvavečih tumorskih lezij, kar se kaže v takojšnji ustavitvi krvavitve in v poznejšem zmanjšanju tumorske lezije. Raziskave je podprla ARRS.
Published in DiRROS: 05.01.2021; Views: 1101; Downloads: 459
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242. Cultivation and utilization of Poplars, Willows and other fast-growing trees in Slovenia : report of the National Poplar CommissionGregor Božič, Andreja Ferreira, Anže Martin Pintar, Gordana Beltram, Marko Kovač, Darja Istenič, Špela Ščap, Marjana Westergren, Marko Bajc, Daniel Zorko, Simon Verebič, Nikica Ogris, Hojka Kraigher, 2020, treatise, preliminary study, study Keywords: Poplar, Willow, Black Walnut, Black Locust, international commission, FAO, national report, questionnaire, genetics, forest protection, legislation, categorisation, forest products, ecology, Slovenia
Published in DiRROS: 11.12.2020; Views: 1351; Downloads: 417
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243. Questionnaire on poplars and other fast-growing trees sustaining people and the environment 2016 - 2019 : report of the National Poplar CommissionGregor Božič, Andreja Ferreira, Anže Martin Pintar, 2020, treatise, preliminary study, study Keywords: Poplar, Willow, Black Walnut, Black Locust, international commission, FAO, national report, questionnaire, genetics, forest protection, legislation, categorisation, forest products, ecology, Slovenia
Published in DiRROS: 11.12.2020; Views: 1309; Downloads: 412
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244. Težke odločitve pri zdravljenju bolnikov z vensko trombembolijo in rakomAna Kovač Bograf, Monika Štalc, Gregor Tratar, Alenka Mavri, 2016, review article Abstract: Venska trombembolija (VTE) je pogost zaplet pri bolnikih z rakom. Zdravljenje VTE pri teh bolnikih predstavlja velik izziv, saj je pri bolnikih z rakom dodatno povečano tako tveganje za trombembolične zaplete kot tudi tveganje za krvavitve. Predstavili bomo nekaj kliničnih situacij, s katerimi se v klinični praksi pogosto srečamo in predstavljajo dileme pri antikoagulacijskem zdravljenju bolnikov z VTE ter rakom, in sicer ponovitve VTE kljub zdravljenju, pojav trombocitopenije, tumorje osrednjega živčevja, uporabo filtrov v spodnji votli veni, uporabo novih peroralnih antikoagulacijskih zdravil in pojav naključno odkrite VTE.
Keywords: venska trombembolija, rak (medicina), zdravljenje
Published in DiRROS: 03.12.2020; Views: 1347; Downloads: 566
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245. Reproducibility of malignant pleural mesothelioma histopathologic subtypingLuka Brčić, Gregor Vlačić, Franz Quehenberger, Izidor Kern, 2018, original scientific article Abstract: Context. Malignant pleural mesothelioma (MPM) is a rare tumor with poor prognosis. Several studies have analyzed potential prognostic markers, but histologic type remains the single most important prognostic factor. Histologic subtypes of epithelioid MPM seem to have prognostic and therapeutic implications. Interobserver agreement in histologic pattern classification should be high. Objective. To assess interobserver and intraobserver reproducibility in histologic differentiation between the main types of MPMs, and in further subtyping of epithelioid-type mesothelioma. Design. One representative hematoxylin-eosin-stained slide was selected from the archive for each of 200 patients with MPM. They were reviewed independently by 3 pathologists and classified according to the current World Health Organization classification of pleural tumors. After the first round of evaluations, a consensus meeting was organized where problems were addressed and representative images for each histologic category were selected. Two months later, cases were reevaluated by all 3 pathologists. Results. After the first round, overall interobserver agreement for histologic subtyping of mesothelioma was fair (k, 0.36). The agreement was increased to substantial (k, 0.63) in the second round. Improvement was found in interobserver agreement for all types of MPM, and for most epithelioid subtypes. Conclusions. Moderate to substantial agreement in histologic typing and subtyping of MPM can be achieved. However, training with additional clarification of diagnostic criteria, their strict application, and help from consensus-based illustrative images is needed.
Keywords: connective and soft tissue neoplasms -- pathology, malignant pleural mesothelioma, histopathology
Published in DiRROS: 30.11.2020; Views: 5927; Downloads: 449
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246. Design of protein logic gate system operating on lipid membranesNeža Omersa, Saša Rezelj, Matic Kisovec, Marjetka Podobnik, Gregor Anderluh, 2020, original scientific article Keywords: pore-forming toxin, listeriolysin O, protein logic gates, lipid membrane, DARPin, pH
Published in DiRROS: 25.11.2020; Views: 1501; Downloads: 860
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247. Effects of a mixed O/F ligand in the Tavorite-type LiVPO[sub]4O structureSorour Semsari Parapari, Jean-Marcel Ateba Mba, Elena Tchernychova, Gregor Mali, Iztok Arčon, Gregor Kapun, Mehmet Ali Gülgün, Robert Dominko, 2020, original scientific article Keywords: XRD, SEM, V XANES, Tavorite-type, electrochemical properties
Published in DiRROS: 25.11.2020; Views: 1614; Downloads: 894
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248. Unique structural features of mule deer prion protein provide insights into chronic wasting diseaseUrška Slapšak, Giulia Salzano, Gregor Ilc, Gabriele Giachin, Jifeng Bian, Glenn Telling, Giuseppe Legname, Janez Plavec, 2019, original scientific article Published in DiRROS: 24.11.2020; Views: 1121; Downloads: 777
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