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Abstract: Background: A hemodialysis catheter may serve as a short- or medium-term vascular access solution. Current guidelines suggest restricting non-tunneled catheter use to 2 weeks, partially based on studies using straight non-tunneled jugular catheters, which have now been widely replaced with pre-curved catheters. We compared the rate of catheter-related blood stream infections (CRBSIs) and possible CRBSIs (PCRBSIs) of pre-curved non-tunneled and tunneled catheters in our hemodialysis center. Methods: This was a retrospective study including patients dialyzed on an outpatient basis between 1 January 2018 and 1 July 2024, with a follow-up until 1 March 2025. The primary aim was to compare the rates of CRBSIs. Results: In 301 patients, 625 non-tunneled single lumen catheter pairs and 53 double lumen tunneled catheters were used. There were 53 CRBSIs in non-tunneled and 10 in tunneled catheters, with identical incidence rate (0.48/1000 catheter-days in both groups). Analyzing CRBSIs and PCRBSIs together also showed similar infection rates [0.66 vs 0.58, incidence rate ratio (IRR) with 95% confidence interval 1.14 (0.6–2.1), P = .68]. Two subanalyses were made: CRBSI IRR in 27 patients with both types of catheters during study period was 1.37 (0.55–3.41, P = .49) and 2.01 (0.52–7.72, P = .47) in 36 patients after their first CRBSI. Time to CRBSI was also comparable in all analyses. Conclusions: Our study found no significant difference in the incidence of CRBSIs. We conclude that prolonged use of non-tunneled pre-curved catheters, which are easily managed, is a viable option for patients awaiting construction of arteriovenous fistula, insertion of a peritoneal catheter or kidney transplantation in a reasonable time. Promising results on long-term use from this study need to be confirmed in prospective studies.
Keywords: catheter-related blood stream infection, chronic hemodialysis, hemodialysis catheter, pre-curved jugular non-tunneled catheters, tunneled hemodialysis catheters
Published in DiRROS: 20.01.2026; Views: 198; Downloads: 155
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Abstract: BackgroundSpinal muscular atrophy is a rare, genetic neuromuscular disorder. Disease-modifying therapies, when administered early, have shown improved outcomes, leading to the implementation of numerous newborn screening programs for spinal muscular atrophy. ObjectiveThe aim of this study was to evaluate the progress in implementing newborn screening for spinal muscular atrophy and therapy accessibility worldwide, after the first paper published in 2021. MethodsWe conducted a survey, contacted experts from 143 countries worldwide, gathered responses from 86 experts from 80 countries. ResultsBy 2023, 31 countries reported established programs, 33 in the beginning of the year 2024; identifying approximately 1176 cases of spinal muscular atrophy. Additionally, the availability of disease-modifying therapies has expanded. At least one therapy is now accessible in 62 countries. Challenges, such as lack of governmental support, resource constraints, and varying healthcare priorities continue to impede implementation in some countries. ConclusionsThe data shows a significant increase in the implementation of newborn screening programs since 2021. The experts are still expressing a strong need for equitable access to standard of care for all the patients globally. Despite all setbacks, collaborative efforts have played a crucial role in newborn screening for spinal muscular atrophy implementation and currently 7% of world newborns are being screened, projections indicate an estimated 18% screening rate by 2028
Keywords: newborn screening, spinal muscular atrophy, pre-symptomatic, nusinersen, risdiplam, onasemnogene abeparvovec
Published in DiRROS: 03.12.2025; Views: 518; Downloads: 159
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Abstract: This dataset supports the tables and figures in the article Effect of sulfide in a 0.2 M NaCl solution on copper and pre-oxidized copper in oxic conditions Effect of sulfide in a 0.2 M NaCl solution on copper and pre-oxidized copper in oxic conditions (https://doi.org/10.1016/j.surfin.2025.107387). The data set contains experimental data for copper and pre-oxidized copper samples exposed to chloride solution (0.2 M Cl–) with different sulfide concentrations (5·10–6 M SH– and 1·10–4 M SH–) at room temperature (22 ± 2 °C) and elevated temperature (60 °C). Corrosion potential was monitored over a period of 24 hours. After 24 h immersion, electrochemical impedance spectroscopy was performed to observe the properties of the surface film formed on the copper and the pre-oxidized copper. The dataset also includes images of pre-oxidized samples after 24 hours immersion in different solutions, original Raman spectra and Raman images, XPS data and images data from the scanning electron microscope and images of cross-section of samples. The dataset was also used for the model of corroding system (Figure 13)
Keywords: copper, pre-oxidized copper, chloride and sulfide environment, electrochemical properties, surface characterization, Raman, cyclic voltammetry
Published in DiRROS: 11.08.2025; Views: 678; Downloads: 425
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Keywords: legumes, NIR, spectroscopy, plant genetic resources, pre-breeding collection, protein content, seed traits
Published in DiRROS: 25.02.2025; Views: 934; Downloads: 502
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Abstract: Timber harvesting constitutes extensive anthropogenic disturbance in temperate forests, producing a broad range of ecological impacts that most often enhance the demographic processes of vegetation. This study monitored post-harvest herb layer demography over a 6-year period in mesic Dinaric fir-beech forests (Slovenia), a vascular plant diversity hotspot among European forests. Three experimental harvesting intensities, i.e. full harvest (FH), partial harvest (PH) and a control treatment (NH), were each applied over a circular area of 4000 m2 and replicated three times at each of three study sites. Vegetation sampling was conducted before harvesting (in 2012), and two (2014) and six (2018) years following it, in a 400 m2 circular plot positioned in the centre of each treatment area. We focused on identifying general demographic patterns and evaluating the effects of various pre-disturbance abiotic and biotic predictors on compositional responses to disturbance. Two years after harvest (2012-2014), compositional shifts were larger than those in the next 4-year period (2014-2018), confirming the general theoretical prediction that species turnover rate decreases along a successional gradient. The degree of compositional shifts in gaps (FH) and thinned stands (PH) was affected by local abiotic factors (geomorphology of karst sinkholes) and community attributes, such as pre-harvest species richness. Our results indicate that compositional stability is positively associated with pre-disturbance species richness. Over the whole study period, increases in plot-level species richness (alpha diversity) and overall enrichment of the species pool (gamma diversity) were accompanied by compositional convergence, i.e. a decline in floristic dissimilarity (beta diversity) between and within study sites. However, the observed tendency towards homogenization was rather weak and would have been even more pronounced if the demographic type of persistent resident species had not shown a high degree of resistance, thus leaving a strong imprint on post-harvest vegetation development by preserving the forest characteristics of the herb layer community.
Keywords: forest succession, demographic types, community assembly, pre-disturbance factors, floristic convergence, fir-beech forests
Published in DiRROS: 22.07.2022; Views: 1454; Downloads: 988
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