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2. Primary vitreoretinal lymphoma : diagnostic and therapeutic insights from a Slovenian population-based studyNika Vrabič, Lučka Boltežar, Matej Panjan, Veronika Kloboves-Prevodnik, Polona Jaki Mekjavić, Marija Skoblar Vidmar, Pia Klobučar, Mojca Globočnik Petrovič, Nataša Vidović Valentinčič, 2026, original scientific article Abstract: Background: This study aimed to determine the national incidence, characterize clinical features, and evaluate the treatment outcomes of primary vitreoretinal lymphoma (PVRL) in Slovenia. Methods: We conducted a population-based, retrospective case series of all patients diagnosed with PVRL at the Eye Hospital, University Medical Center Ljubljana, between January 2013 and May 2024. The diagnosis was histopathologically confirmed, and primary central nervous system involvement was excluded. Clinical presentation, diagnostic delay, treatment modality, and adverse events were analyzed. Progression-free survival (PFS), overall survival (OS), and lymphoma-specific survival (LSS) were calculated. Results: Twelve patients were diagnosed with PVRL (four men, eight women; median age of 76 years). The average annual incidence was 0.52 cases per million. The median time from symptom onset to diagnosis was 238 days. The two most common symptoms were decreased visual acuity (75%) and floaters (58%). Vitreous cellular infiltration was the predominant clinical sign and was observed in 92% of patients. Five patients presented with unilateral disease, seven with bilateral disease, and three with unilateral disease that progressed to bilateral involvement. The median follow-up was 31.5 months. Eleven patients received one or more treatment modalities: intravitreal rituximab and/or methotrexate, local radiotherapy, and/or systemic chemotherapy. Local remission was achieved in all treated eyes. Two cases of granulomatous uveitis occurred during intravitreal rituximab therapy. The median PFS was 12 months; the two- and three-year PFS rates were 37.5% and 18.8%, respectively. The median OS was not reached; the two- and three-year OS rates were 70% and 56%, respectively. The LSS was 80% at two years and 64% at three years. Conclusions: This Slovenian population-based study provides real-world insights into PVRL management. In elderly and medically fragile patients, local treatment modalities provided effective ocular disease control with acceptable toxicity.
Keywords: methotrexate, population-based study, primary vitreoretinal lymphoma, radiotherapy, survival analysis
Published in DiRROS: 24.04.2026; Views: 168; Downloads: 112
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3. Vpliv sistemske terapije na cirkulirajoče tumorske celice in skupke cirkulirajočih tumorskih celicKlara Grad, Sara Šauer, Erika Matos, Domen Ribnikar, Nataša Snoj Šarvari, Tanja Ovčariček, Veronika Škrjanc, Živa Pišljar, Maja Čemažar, Simona Miceska, Tanja Jesenko, Veronika Kloboves-Prevodnik, Cvetka Grašič-Kuhar, 2025, published scientific conference contribution abstract Keywords: eksperimentalna onkologija, sistemska terapija, cirkulirajoče celice
Published in DiRROS: 18.03.2026; Views: 362; Downloads: 134
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4. Vzpostavitev mišjega modela trojno negativnega raka dojk 4T1 za proučevanje cirkulirajočih tumorskih celic in procesa zasevanjaVeronika Škrjanc, Simona Kranjc Brezar, Maja Čemažar, Boštjan Markelc, Cvetka Grašič-Kuhar, Simona Miceska, Veronika Kloboves-Prevodnik, Tanja Jesenko, 2025, published scientific conference contribution abstract Keywords: citopatologija, diagnostična dejavnost, onkologija
Published in DiRROS: 18.03.2026; Views: 276; Downloads: 124
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5. Ovrednotenje cirkulirajočih tumorskih celic in celičnih skupkov pri bolnicah s primarnim, napredovalnim seroznim rakom jajčnika visokega gradusa pred neoadjuvantnim sistemskim zdravljenjemSimona Miceska, Tanja Jesenko, Nina Pišljar, Erik Škof, Cvetka Grašič-Kuhar, Veronika Kloboves-Prevodnik, 2025, published scientific conference contribution abstract Keywords: citopatologija, diagnostična dejavnost, onkologija
Published in DiRROS: 11.03.2026; Views: 286; Downloads: 146
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8. Ell quantity in nodal T-follicular helper cell lymphomas and peripheral T-cell lymphomas, not otherwise specified and its correlation with overall survivalEva Erzar, Alexandar Tzankov, Janja Ocvirk, Biljana Grčar-Kuzmanov, Lučka Boltežar, Veronika Kloboves-Prevodnik, Gorana Gašljević, 2024, published scientific conference contribution Published in DiRROS: 25.02.2026; Views: 390; Downloads: 114
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9. Nodal T-follicular helper cell lymphomas and peripheral T-cell lymphomas, not otherwise specified in Slovenian patients : mutational landscape, clinicopathological characteristics and outcomesEva Erzar, Vanesa-Sindi Ivanova, Stefan Dirnhofer, Lučka Boltežar, Janja Ocvirk, Veronika Kloboves-Prevodnik, Alexandar Tzankov, Gorana Gašljević, 2024, published scientific conference contribution Published in DiRROS: 25.02.2026; Views: 343; Downloads: 114
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10. Ocena proliferacijskega indeksa Ki-67 v citoloških vzorcih nodalnih B-celičnih limfomovVeronika Kloboves-Prevodnik, Simona Miceska, Mojca Založnik, Simon Buček, Nataša Nolde, Mojca Gjidera, Ulrika Klopčič, Zorica Čekić, Živa Pohar-Marinšek, Gorana Gašljević, 2024, published scientific conference contribution abstract Keywords: limfomi, patologija, onkologija
Published in DiRROS: 25.02.2026; Views: 348; Downloads: 95
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