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Abstract: Episodes of acute exacerbations are major drivers of hospitalisation and death from COPD. To date, there are no objective biomarkers of disease activity or biomarkers to predict patient outcome. In this study, 211 patients hospitalised for an acute exacerbation of COPD have been included. At the time of admission,routine blood tests have been performed including complete blood count, C-reactive protein, cardiac troponin T and NT-proBNP. Heat shock protein 27 (HSP27) serum concentrations were determined at time of admission, discharge and 180 days after discharge by ELISA. We were able to demonstrate significantly increased HSP27 serum concentrations in COPD patients at time of admission to hospital as compared to HSP27 concentrations obtained 180 days after discharge. In univariable Cox regression analyses, a HSP27 serum concentration >/= 3098 pg/mL determined at admission was a predictor of all-cause mortality at 90 days, 180 days, 1 year and 3 years. In multivariable analyses, an increased HSP27 serum concentration at admission retained its prognostic ability with respect to all-cause mortality for up to 1year follow-up. However, an increased HSP27 serum concentration at admission was not an independent predictor of long-term all-cause mortality at 3 years. Elevated serum HSP27 concentrations significantly predicted short-term mortality in patients admitted to hospital with acute exacerbation of COPD and could help to improve outcomes by identifying high-risk patients.
Keywords: COPD, acute exacerbation, disease activity
Published in DiRROS: 29.07.2020; Views: 1724; Downloads: 1063
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Keywords: pljučne bolezni, alergologija, molekularna alergologija, intersticijske pljučne bolezni, rak (medicina), infekcijske bolezni, bronhoskopija, astma, kronična obstruktivna pljučna bolezen, pljučna tuberkuloza, hipoventilacija, sindrom apneje v spanju, diagnostika, zdravljenje, zborniki, povzetki
Published in DiRROS: 09.06.2020; Views: 2311; Downloads: 1219
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Keywords: ZORA, ginekologija
Published in DiRROS: 07.04.2020; Views: 1346; Downloads: 348
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Abstract: Severe droughts have the potential to reduce forest productivity and trigger tree mortality. Most trees face several drought events during their life and therefore resilience to dry conditions might be crucial to long-term survival. We assess how growth resilience to severe droughts, including its components resistance and recovery, is related to the ability to survive future droughts by using a tree-ring database of surviving and now-dead trees from 118 sites (22 species, >3,500 trees). We find that, across the variety of regions and species sampled, trees that died during water shortages were less resilient to previous non-lethal droughts, relative to coexisting surviving trees of the same species. In angiosperms, drought-related mortality risk is associated with lower resistance (low capacity to reduce impact of the initial drought), while it is related to reduced recovery (low capacity to attain pre-drought growth rates) in gymnosperms. The different resilience strategies in these two taxonomic groups open new avenues to improve our understanding and prediction of drought-induced mortality. Resilience to drought is crucial for tree survival under climate change. Here, DeSoto et al. show that trees that died during drought were less resilient to previous dry events compared to surviving conspecifics, but the resilience strategies differ between angiosperms and gymnosperms.
Keywords: trees, mortality, gymnosperms, angiosperms, drought, resilience, resistance, recovery
Published in DiRROS: 20.02.2020; Views: 1770; Downloads: 1105
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Keywords: študij gozdarstva, obletnice, gozdarstvo, visokošolsko izobraževanje, Biotehniška fakulteta, Oddelek za gozdarstvo in obnovljive gozdne vire
Published in DiRROS: 20.12.2019; Views: 2377; Downloads: 658
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