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Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies
Jean Bousquet, Jean-Paul Cristol, Wienczyslawa Czarlewski, Josep M. Antò i Boquè, Adrian Martineau, Tari Haahtela, Susana C. Fonseca, Guido Iaccarino, Hubert Blain, Alessandro Fiocchi, Nisera Bajrović, Natalija Edelbaher, Maja Jošt, Peter Kopač, Anja Koren, Mitja Košnik, Karmen Kramer Vrščaj, Samo Kreft, Nika Lalek, Bojan Madjar, Tonka Poplas-Susič, Irma Rozman Sinur, Tanja Soklič, Katja Triller Vadnal, Nadja Triller, Jure Urbančič, Mihaela Zidarn, 2020, review article

Abstract: There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR[gamma]:Peroxisome proliferator-activated receptor, NF[kappa]B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2[alpha]:Elongation initiation factor 2[alpha]). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
Keywords: Covid-19, SARS-CoV-2, food, insulin resistance, obesity, Nrf2, nutrients, TRPA1
Published in DiRROS: 25.01.2021; Views: 1535; Downloads: 592
.pdf Full text (1,61 MB)

Rak pljuč, klinični znaki, diagnostika in načini zdravljenja
Nadja Triller, 2012, published professional conference contribution

Published in DiRROS: 23.01.2020; Views: 1555; Downloads: 473
.pdf Full text (103,72 KB)

Državni program obvladovanje raka in Klinika Golnik
Mitja Košnik, Tanja Čufer, Nadja Triller, 2011, published professional conference contribution

Keywords: Slovenija, državni programi, onkologija
Published in DiRROS: 17.09.2019; Views: 2088; Downloads: 561
.pdf Full text (95,28 KB)

Naše izkušnje s citostatskim zdravljenjem drobnoceličnega pljučnega raka
Andrej Debeljak, Nadja Triller, Peter Kecelj, M... Šluga, 1998, published scientific conference contribution

Published in DiRROS: 17.09.2019; Views: 1959; Downloads: 553
.pdf Full text (414,77 KB)

Paraneoplastični sindrom pri pljučnem raku
Nadja Triller, Andrej Debeljak, 1998, published scientific conference contribution

Published in DiRROS: 17.09.2019; Views: 1910; Downloads: 502
.pdf Full text (282,30 KB)

Dispneja in kašelj
Nadja Triller, 2005, published professional conference contribution

Published in DiRROS: 17.09.2019; Views: 1736; Downloads: 434
.pdf Full text (423,69 KB)

Celovita obravnava bolnika s pljučnim rakom na Kliniki Golnik
Nadja Triller, 2010, published professional conference contribution

Keywords: pljučni rak, celovita obravnava
Published in DiRROS: 17.09.2019; Views: 1989; Downloads: 510
.pdf Full text (125,19 KB)

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