21. Detection of early lung cancer lesions in surgical resections and in bronchial and transbronchial biopsiesTomaž Rott, Maja Jerše, Marjeta Terčelj-Zorman, Janez Eržen, 2006, published scientific conference contribution (invited lecture) Abstract: Background. Overall bad progmpsis of lung is mostly due to too late detection of early lung cancer, which may be teated with good success. Therefore different diagnostic methods are developing for more efficient detection of early lung cancer: besides modern radiological, bronchoscopic methods with additional fluorescence techniques, quantitative cytological investigations, also histological and molecular investigations are included. History may reveal early preinvasive lung xcancer lesions, associated early during multistep lung carcinogemesis with molecular genetic changes. Patients and methods. Preinvasive epithelial lung cancer lesions we searched in two groups of patients. In the first group of 316 patients from the period March 2003 - August 2006, 498 bronchial and transbronchial biopsies were examined for squamous metaplasia and dysplasia, carcinoma in situ, and invasive tumours. Inthe second group of 238 patients from the period January 2004 - August 2006,resected primary lung tumours were analysed for preinvasive neuroendocrine tumours and atypical adenomatous hyperplasia. Resuots. The mostfrequent changes in bronchial and transbronchial biopsies were squamous metaplasia (46.5%), simple or goblet cell hyperplasia of the bronchial epithelium (44.3%), malignant tumours (20.66%) and squamous dysplasia (16.1%),but rare carcinoma in situ (0.63%). Diffuse idiopoathic pulmonary neuroendocrine cell hyperplasia was found in 15 (6.3%) cases in the vicinity of 238 resected lung cancer specimens, carcinoid in12 patients (5%), and mostly combined large neuroendocrine cancer in 21 patients (8.8%). Atypical denomatous hyperplasia was found in 2 patients. Conculsions. Classical histological analysis should be focused on detection of early preinvasive epithelial lung cancer lesions. (Abstract truncated at 2000 characters).
Published in DiRROS: 05.12.2023; Views: 190; Downloads: 52
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22. Pomen humanih virusov papiloma pri odkrivanju in preprečevanju raka materničnega vratu - kje smo danesMarjetka Uršič-Vrščaj, Sonja Bebar, Andrej Možina, Stelio Rakar, Iztok Takač, Vida Stržinar, Aleš Vakselj, 2006, published professional conference contribution Abstract: Izhodišča. S pomočjo organiziranih programov presejanja se je zmanjšala umrljivost zaradi raka materničnega vratu. Humani virusi papiloma (HPV) povzročajo predrakave spremembe in raka materničnega vratu. Številne ugotovitve kažejo, da je z vključevanjem testa HPV mogoče izboljšati uspešnost presejalnih programov. Test HPV se omenja pri presejanju, pri triažiranju bolnic z začetno patološkimi brisi materničnega vratu in po zdravljenju predrakavih sprememb. Visoka negativna napovedna vrednost dvakrat negativnega testa, testa PAP in testa HPV, naj bi na področju presejanja omogočala določene spremembe, kot so podaljševanje priporočenega rednega intervala presejanja, prilagajanje starosti ter ponovno presejanje po zdravljenju predrakavih sprememb. Test HPV je klinično pomemben pri triažiranju žensk s ponavljajočimi se atipičnimi ploščatimi celicami, pri katerih je potrebna kolposkopija. Zaradi visoke prevalence okuženosti s HPV se test HPV kaže kot omejitev pri zelo mladih ženskah z blago diskariotičnimi celicami. Zaključki. Ugotovitve o HPV nakazujejo možnosti za preprečevanje raka materničnega vratu na področju profilaktičnega cepljenja. V svetovnem merilu HPV 16 in 18 povzročata 70 % raka materničnega vratu. V prihodnjem letu naj bi bili dostopni dve profilaktični cepivi, učinkoviti proti HPV 16 in 18.
Published in DiRROS: 05.12.2023; Views: 234; Downloads: 56
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26. Doktrinarni problemi diagnostičnega algoritma retroperitonealnega prostoraJurij Us, Franci-Stanko Marolt, Marjeta Stanovnik, Jože Stropnik, Erika Brenčič, Marjeta Demšar, V. Istenič, E. Baretič-Kolar, Marko Kralj, 1982, professional article Keywords: radiologija, intervencijska radiologija
Published in DiRROS: 14.09.2023; Views: 255; Downloads: 60
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27. Modificirajući uticaj na neke endokrine žlezde miša kod kasnih posledica subletalnog jonizacionog zračenjaMiroslav Kališnik, Olga Vraspir-Porenta, Metka Logonder-Mlinšek, Marjeta Zorc, Tatjana Lejko-Zupanc, Alenka Rus-Gaši, Draga Štiblar-Martinčič, Janez Škrk, 1979, original scientific article Published in DiRROS: 14.09.2023; Views: 265; Downloads: 60
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28. Značaj kombinacije savremenih dijagnostičkih metoda u diferenciranoj dijagnostici tumora štitnjačeMarija Auersperg, Jožica Červek, Marjan Erjavec, Rastko Golouh, Marinka Kremžar, Janez Lamovec, Marija Us-Krašovec, Jurij Us, Franci-Stanko Marolt, Jasna Sever, Janez Novak, Miran Porenta, Marija Snežna Paulin-Košir, Ivana Levstik, Milan Valter Schara, Marjeta Šentjurc, 1977, original scientific article Published in DiRROS: 14.09.2023; Views: 273; Downloads: 83
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