11. Cerebral hyperperfusion syndrome after carotid angioplastyZoran Miloševič, Bojana Žvan, Marjan Zaletel, Miloš Šurlan, 2002, published scientific conference contribution Abstract: Background. Cerebral hyperperfusion syndrome after carotid endarterectomy is an uncommon but well-de- fined entity. There are only few reports of "hyperperfusion injury" following carotid angioplasty. Case report. We report an unstable arterial hypertension and high grade carotid stenosis in a 58-year-old, right-handed woman. After a stroke in the territory of middle cerebral artery carotid angioplasty was per- formed in the patient. Among riskfactors, the long lasting arterial hypertension was the most pronounced. Immediately after the procedure, the patient was stable without any additionalneurologic deficit. The sec- ond day, the patient had an epileptic seizure and CT revealed a small haemorrhage in the left frontal lobe. Conclusions. The combination of a high grade carotid stenosis and unstable arterial pressure is probably an important prognostic factor in the pathogenesis of hyperperfusion syndrome.
Published in DiRROS: 31.01.2024; Views: 119; Downloads: 37
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12. Carotid angioplasty with cerebral protectionZoran Miloševič, Bojana Žvan, Marjan Zaletel, Miloš Šurlan, 2002, original scientific article Abstract: Background. Carotid endarterectomy (CF.A) is widely used in the management of high-rade carotid stenosis: It is a surgical procedure requiring general anaesthesia and is suitable only for lesions located at or close to the carotid bifurcation. It may develop complications, such as stroke, death, cranial nerve palsies, wound haematoma and cardiac complications. The risk of complications is increased in patients with recurrent carotid artery stenosis following CEA, in subjects undergoing radiotherapy to the neck, and in patients with cardiopulmonary disease. The drawbacks of CEA have led physicians to search for alternative treatment options. Carotid angioplasty and stenting (CAS) is less invasive than CEA. The method is particularly suitable for the treatment of recurrent stenosis after previous CEA and distalinternal artery stenosis, which is inaccessible for CEA. CAS does not cause cranial nerve palsies. Moreover, it does not require general anaesthesiaand causes lower morbidity and mortality in patients with severe cardiopulmonary disease. The complications of CAS include stroke due to distalimmobilisation of a plaque or thrombus dislodged during the procedure, abrupt vessel occlusion due to thrombosis, dissection or vasospasm, and restenosis due to intmal hyperplasia. CAS is a relatively new procedure; therefore, it is essential to establish its efficacy and safety before it is introduced widely into clinical practice. Patients and methods. In Slovenia, we have also started with carotid angioplasty by the study: Slovenian Carotid Angioplasty Study (SCAS). We performed CAS in 17 patients (12 males and 5 females) aged from 69 to 82 years. All patients were symptomatic with stenosisgreater than 70 %. 10 patients suffered transient ischemic attacks, 4 patients minor strokes and 3 patients amaurosis fugax. (Abstract truncated at 2000 characters)
Published in DiRROS: 31.01.2024; Views: 155; Downloads: 35
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13. Legislation on the protection of experimental animalsDragica Ornik, Milan Pogačnik, 2001, review article Abstract: The aim of this paper is to establish the current situation in the field of legislation on the protection of experimental animals in Slovenia. The protection of experimental animals has been regulated by the provisions of theProtection of Animals Act.1 On the basis of this act, the Instructions on Conditions for the Issuing of Authorisations for Experiments on Animals for Scientific and Research Purposes2 and the Rules on the Ethics Commission for Experiments on Animals 3 have been used. The basic protection of experimental animals is provided for by a system of permits for experiments on animals. Permits for experiments on animals are granted by the administrative authorities responsible for veterinary medicine in cases where experiments areurgently required for medical, veterinary medical, or scientific and research purposes and the results are expected to produce important new knowledge, or when the suffering of animals is ethically acceptable in comparison with what the experiment is expected to achieve; where, in cases ofbasic research, experimental aims cannot be achieved by any other method or procedure, the experiment is performed on the minimum possible number of animals of the lowest neurophysiological sensitivity and a method is used thatcauses the minimum level of suffering, pain or lasting harm. Staff involved in the execution of experiments or in the care and nursing of animals, the premises for the accommodation or rearing and provision of animals, and the installations and devices used must all comply with the set conditions. (Abstract truncated at 2000 characters)
Published in DiRROS: 26.01.2024; Views: 164; Downloads: 38
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14. Persistent chromosomal aberrations in somatic cells in testicular cancer patients after different therapiesCvetka Bilban-Jakopin, Marjan Bilban, 2001, original scientific article Abstract: Background. The damage due to radiation or chemotherapeutic agents has been estimated successfully for the last 35 years from the numbers of the chromosome changes. This finding may serve as biological dosimeter. The aim ofthe study was to find persistent chromosomal aberrations in somatic cells intesticular cancer patients after different therapies. Patients and methods. This prospective study includes 60 patients with testicular tumours. With respect to the histological results and various therapies that they were giventhey were divided into four groups. Prior to treatment, we did not detectany deviations either in the genome picture of our patients or in that of the subjects of the control group without malignant disease. The changes inthe genome of individual cells after therapy were detected by the following tests: structural chromosomal aberrations (SCA) test, sister chromatid exchange (SCE) test and micronucleus (MN) test performed on binuclear lymphocytes. (Abstract truncated at 2000 characters)
Published in DiRROS: 26.01.2024; Views: 158; Downloads: 35
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16. Cytology of mediastinal tumorsMilivoj Mermolja, Izidor Kern, Marjeta Terčelj-Zorman, Marjan Jereb, 1997, original scientific article Abstract: Our experience with cytological examinations of tumorous mediastinal lesions is evaluated. A group of 117 patients with mediastinal tumor have been included into the study. Among them carcinomas prevailed (60,7%), followed by lymphomas (18,8%), other tumors (15.4%) and thymic neoplasms (5.1%). Malignantor suspicious cells were found in 77.4% of patients with carcinoma. The cells indicating a possibility of non-Hodgkin's lymphoma were found in 9 out of 14 patients. In 5 out of 6 thymic neoplasms the cytological pattern wasconsistent with the diagnosis of thymic neoplasm. One case of thymoma was cytologically falsely diagnosed as malignant lymphoma. One case of neurofibroma was falsely diagnosed as adenocarcinoma. The sensitivity of cytological examinations was 67.5%. If 18 patients with diagnostically unsatisfactory material were excluded from the analysis, the sensitivity wouldincrease to 80.8%. Owing to the wide variety of primary and metastatic tumors that can occur in the mediastinum, apart from the routine cytological techniques, additional staining methods should be used. For final cytological diagnosis the integration of cytological findings with clinical and radiological data is often required. Owing to the characteristics of the obtained material and biological behaviour of some mediastinal tumors, some tumors cannot be definitively diagnosed by cytological examinations alone.
Published in DiRROS: 18.01.2024; Views: 184; Downloads: 51
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