1. Sustained circulation of enterovirus D68 in Europe in 2023 and the continued evolution of enterovirus D68 B3-lineages associated with distinct amino acid substitutions in VP1 proteinAurora Hirvonen, Caroline K. Johannesen, Peter Simmonds, Thea K Fischer, Kimberley Benschop, 2025, original scientific article Abstract: Background Enterovirus D68 (EV-D68) causes respiratory disease ranging from mild to severe and in rare cases a paralytic syndrome, called acute flaccid myelitis (AFM). Since the global EV-D68 outbreak in 2014, the virus has mainly circulated in biennial epidemic cycles with peaks detected during even years. However, following the COVID-19 pandemic, the seasonal pattern of EV-D68 has been characterized by large yearly upsurges. Here, we describe the circulation of EV-D68 in Europe in 2023 and track its genetic evolution. Study design Data was compiled from members of the European Non-Polio Network (ENPEN). This included monthly data on the total number of EV samples tested, EV positive samples, EV-D68 positive samples and cases, and other EV positive samples detected in 2023. Information on sample types and surveillance system was recorded. Sequence data from the VP1 gene was used for phylogenetic and amino acid sequence analysis. Results EV was detected in 13,585 out of 203,622 diagnostic samples tested (6.7 %), of which 402 (3.0 %) were determined as EV-D68, representing 386 cases. EV-D68 infections peaked in October 2023 (136/386; 35.2 %). 267/386 (69.2 %) of EV-D68 cases were captured through clinical EV surveillance, almost all of which (202/204 of positive samples with sample type information) were detected in respiratory specimens. Phylogenetic analysis performed on 99 VP1 sequences revealed a distinct B3-derived lineage with a previously undescribed residue change, D554E, in Europe. Conclusions The study documents sustained circulation of EV-D68 in Europe in 2023, the evolution of B3-derived lineages, and appearance of previously undescribed amino acid substitutions in Europe. This stresses the need for continuous EV-D68 surveillance and harmonization of EV-D68 detection practices towards better data comparability across countries.
Keywords: Enterovirus D68 (EV-D68), Europe, Epidemiology, B3-derived, lineages, Surveillance
Published in DiRROS: 27.06.2025; Views: 488; Downloads: 322
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2. Clinical relevance of the borderline results of the Hybrid Capture 2 High-Risk HPV DNA assay with cervical samples collected in Specimen Transport MediumJerneja Varl, Urška Ivanuš, Živa Pohar-Marinšek, Tine Jerman, Anja Oštrbenk Valenčak, Mario Poljak, Veronika Kloboves-Prevodnik, 2019, original scientific article Keywords: Hybrid Capture 2, cervical cancer, HPV test, borderline results
Published in DiRROS: 05.07.2024; Views: 1002; Downloads: 577
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3. Randomised trial of HPV self-sampling among non-attenders in the Slovenian cervical screening programme ZORA : comparing three different screening approachesUrška Ivanuš, Tine Jerman, Alenka Repše-Fokter, Iztok Takač, Veronika Kloboves-Prevodnik, Mateja Marčec, Uršula Salobir Gajšek, Maja Pakiž, Jakob Koren, Simona Hutter-Čelik, Kristina Gornik-Kramberger, Ulrika Klopčič, Rajko Kavalar, Simona Šramek Zatler, Biljana Grčar-Kuzmanov, Mojca Florjančič, Nataša Nolde, Srdjan Novaković, Mario Poljak, Maja Primic-Žakelj, 2018, original scientific article Published in DiRROS: 11.06.2024; Views: 1114; Downloads: 801
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4. Sinonasal inverted papilloma associated with squamous cell carcinomaJasna But-Hadžić, Klemen Jenko, Mario Poljak, Boštjan Kocjan, Nina Gale, Primož Strojan, 2011, original scientific article Keywords: rak (medicina), papiloma virusi, nosna votlina, karcinom, zdravljenje, radioterapija
Published in DiRROS: 18.03.2024; Views: 1482; Downloads: 383
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5. p53 and lung cancer - more frequent p53 overexpression in patients with multiple primary tumoursTomaž Rott, Mario Poljak, Olga Staniša, Janez Orel, Andrej Debeljak, 1994, professional article Keywords: rak (medicina), pljuča, pljučni rak, biokemija, geni
Published in DiRROS: 11.01.2024; Views: 1395; Downloads: 418
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7. Navodila ginekologom za delo v programu ZORA : posodobitev 2011Maja Primic-Žakelj, Marjetka Uršič-Vrščaj, Ana Pogačnik, Urška Ivanuš, Andrej Možina, Živa Pohar-Marinšek, Mario Poljak, 2011, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: citodiagnostika, presejanje, papiloma virusi, kolposkopija, predrakave spremembe, diagnostika, zdravljenje, zborniki
Published in DiRROS: 04.06.2020; Views: 2936; Downloads: 1021
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8. Zbornik predavanj2015, proceedings of peer-reviewed scientific conference contributions (domestic conferences) Keywords: papiloma virusi, vakcinacija, presejanje, konizacija, prezgodnji porod, citodiagnostika, predrakave spremembe, kolposkopija, program ZORA, ploščatocelični karcinom, genetsko svetovanje, histopatologija, kazalniki kakovosti, zborniki
Published in DiRROS: 02.06.2020; Views: 3293; Downloads: 1185
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9. Zbornik predavanj2017, proceedings of peer-reviewed scientific conference contributions (domestic conferences) Keywords: papiloma virusi, presejanje, citodiagnostika, predrakave spremembe, program ZORA, triaža, test HPV, informacijski sistemi, zborniki
Published in DiRROS: 02.06.2020; Views: 2947; Downloads: 940
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