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Query: "author" (Margareta Strojan Fležar) .

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1.
Image cytometry analysis of normal buccal mucosa smears: influence of smoking and sex-related differences
Jaka Lavrenčak, Margareta Strojan Fležar, Mario Žganec, Marija Us-Krašovec, 1998, original scientific article

Abstract: To get more information about the influence of smoking on chromatin pattern ofnormal buccal mucosa cells and to assess sex-related differences in nuclear features, quantitative analysis of normal buccal mucosa smears was performed. In this study, buccal smears were collected from 78 healthy subjects. Image cytometry analysis was performed on Feulgen-thionin stained smears. probability distributions of 78 nuclear features were calculated for both, cell-by-cell and slide-by-slide classifications. Seven nuclear features showeddiscriminative ability between smokers and non-smokers; most of them were nuclear texture features. Statistical analysis of nuclear features in groups of females and males hoswed that only two nuclear features were different. It is concluded that smoking should be considered in image cytometry analysis of lesions in oral cavity.
Published in DiRROS: 19.01.2024; Views: 104; Downloads: 32
.pdf Full text (1,23 MB)

2.
Longitudinal study of malignancy associated changes in progressive cervical dysplasia
Margareta Strojan Fležar, Jaka Lavrenčak, Mario Žganec, Marija Us-Krašovec, 1998, original scientific article

Abstract: Eight of 29 patients with progressive CIN were followed for 2 to 10 years. Their consecutive Pap smears were destained and stained according to Feulgen thionin method. Cyto-Savant/TM high resolution image cytometer (Oncometrics Technol. Corp., Vancouver, Canaderage values of muclear texture features and their probability distributions for consecutive Pap smears from each patient were calculated. Three out of 5 discriminant MAC, highDNAamount, highDNAcomp and highDNAarea, were to increase as a function of time in 5 out of 8 patients. A preliminary analysis which was performed on non-standardized archival material demonstrated a monotonous increase of discrete texture features as a function of time in patients with progressive CIN.
Published in DiRROS: 19.01.2024; Views: 111; Downloads: 29
.pdf Full text (1,39 MB)

3.
Citodiagnostika netipljivih lezij v dojkah
Ana Pogačnik, Margareta Strojan Fležar, 2004, published scientific conference contribution

Abstract: Izhodišča. Aspiracijska biopsija s tanko iglo (ABTI) je uveljavljena metoda zadiagnostiko sprememb v dojki. V pričujoči študiji smo želeli ugotoviti zanesljivost ultrazvočno (UZ) ali rentgensko (RTG) vodene ABTI za diagnostiko netipljivih lezij v dojki na podlagi cito-histološke korelacije in izračunati občutljivost, specifičnost, napovedno veljavnost pozitivne in negativne diagnoze. Bolniki in metode. V retrospektivno študijo smo vključili 179 žensk,pri katerih je bila v letu 2003 izvršena UZ ali/in RTG vodena ABTI netipljive lezije v dojki, ki je bila kasneje histološko opredeljena na vzorcubiopsije z debelo iglo, vodeni ekscizijski biopsiji ali na kirurškem resektatu. Rezultati. V 66 (36,8%) primerih je bil histološko dokazan karcinom, v 113 (63,1%) primerih pa benigna lezija. Citopatološke diagnoze v skupini karcinomov so bile: karcinom v 41 primerih (62,1%), sumljivo za karcinom v 12 (18,2%), napačno negativna diagnoza v 3 (4,5%), v 10 (15%) primerih pa niso dobili dovolj materiala za diagnozo. Zaključki. V skupini benignih lezij smo iz vzorca ABTI postavili pravilno negativno diagnozo v 55 primerih (48,7%), napačno sumljivo v 18 (15,9%), napačno pozitivno diagnozo v enem primeru (0,88%) in v 39 (34,5%) primerih nismo dobili dovolj materiala zadiagnozo. Občutljivost metode v naši študiji je bila 91%, specifičnost 98%, napovedna veljavnost pozitivne diagnoze 97,6% in napovedna veljavnost negativne diagnoze 94,8 %.
Published in DiRROS: 01.12.2023; Views: 127; Downloads: 47
.pdf Full text (323,74 KB)

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Navodila za citološke izvide brisov materničnega vratu : klasifikacija po Bethesdi
Ana Pogačnik, Margareta Strojan Fležar, Alenka Repše-Fokter, Vivijana Snoj, Irena Srebotnik-Kirbiš, Maja Primic-Žakelj, 2020, dictionary, encyclopaedia, lexicon, manual, atlas, map

Abstract: V Sloveniji poteka državni presejalni program za zgodnje odkrivanje predrakavih sprememb (ZORA) materničnega vratu od leta 2003. Od leta 2003 do 2008 smo znižali obolevnost za rakom materničnega vratu za skoraj 40 %, vendar pa uspešnost programa lahko še izboljšamo, tudi z rednim preverjanjem kakovosti dela ginekologov in citoloških laboratorijev, saj je spremljanje in nadziranje kakovosti vseh postopkov bistveni sestavni del vseh organiziranih presejalnih programov. Register ZORA zbira izvide brisov materničnega vratu (BMV) iz vseh desetih slovenskih laboratorijev, ki ustrezajo pogojem, določenim v Uradnem listu RS. Z registracijo vseh izvidov BMV smo vzpostavili učinkovit sistem spremljanja kakovosti vseh presejalnih postopkov.
Keywords: bris, citopatologija, klasifikacija, terminologija, elektronske knjige
Published in DiRROS: 10.03.2022; Views: 675; Downloads: 290
.pdf Full text (3,83 MB)
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Delovanje citopatoloških in histopatoloških laboratorijev v času pandemije COVID-19 s prikazom primera
Margareta Strojan Fležar, 2020, published scientific conference contribution

Keywords: citopatologija, histopatologija, predrakave spremembe
Published in DiRROS: 17.05.2021; Views: 800; Downloads: 405
.pdf Full text (3,08 MB)
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Zbornik
proceedings of professional or unreviewed scientific conference contributions

Published in DiRROS: 09.06.2020; Views: 1544; Downloads: 641
.pdf Full text (7,85 MB)

10.
Zbornik predavanj
2013, proceedings of peer-reviewed scientific conference contributions (domestic conferences)

Keywords: presejanje, citodiagnostika, predrakave spremembe, kolposkopija, adenokarcinom, program ZORA, zborniki
Published in DiRROS: 05.06.2020; Views: 1663; Downloads: 497
.pdf Full text (3,06 MB)

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