101. Priprava in testiranje tumorske vakcine z obsevanjemTinkara Remic, Gregor Serša, Maja Čemažar, Katja Uršič Valentinuzzi, Kristina Levpušček, Urška Kamenšek, 2021, published scientific conference contribution Keywords: genski elektroprenos, obsevanje, tumorska vakcina
Published in DiRROS: 01.04.2022; Views: 630; Downloads: 199
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102. Characterizing the groundwater flow regime in a landslide recharge area using stable isotopes: a case study of the Urbas landslide area in NW SloveniaKatja Koren, Luka Serianz, Mitja Janža, 2022, original scientific article Abstract: Slope stability strongly depends on the prevailing hydrological and hydrogeological conditions. The amount and intensity of precipitation and changing groundwater levels are important landslide triggering factors. Environmental tracers, including the chemical and stable isotope compositions of precipitation and groundwater, were used to gain insight into the groundwater dynamics of the Urbas landslide. The landslide is situated in a mountainous area with steep slopes and high precipitation amount and poses a high risk for the safety of the Koroška Bela settlement that lies downstream. The stable isotope analyses of oxygen-18 (18O) and deuterium (2H) in the precipitation and groundwater were used to estimate the groundwater mean residence time and the average altitude of the landslide recharge area. This information will help to plan and prioritize remedial landslide measures aiming to reduce the recharge of the landslide body and, thus, lower the risk of transformation of the sliding material into debris flow. The results of the chemical analysis of samples taken from springs and a piezometer show a Ca–HCO3 water type. This indicates low water–rock interaction in a landslide area composed of Upper Carboniferous and Permian clastic rocks and points to upper laying carbonate rocks and scree deposits as the main recharge area. Water samples for stable isotope analyses of δ18O and δ2H were collected from a rain gauge, springs, and a piezometer over a two-year period (2018–2020). The estimated mean recharge altitude of the groundwater at sampling points was from approximately 1700 to 1800 m a.s.l. with a mean residence time of 2–5 months.
Keywords: landslide, groundwater, stable isotopes, oxygen-18, deuterium, hydrogeology, recharge dynamic
Published in DiRROS: 16.03.2022; Views: 758; Downloads: 313
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104. Zdrava izbira - organizirana presejanja za raka v SlovenijiKatja Jarm, Dominika Novak-Mlakar, Urška Ivanuš, Tatjana Kofol-Bric, Ana Šinkovec, Mojca Florjančič, Kaja Batista, 2021, published professional conference contribution Keywords: presejalni programi, preventivni programi, onkologija, javno zdravje
Published in DiRROS: 17.12.2021; Views: 820; Downloads: 282
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106. Prehrana in rak : kaj jesti, če zbolimoNada Rotovnik-Kozjek, Denis Mlakar-Mastnak, Katja Kogovšek, Irena Sedej, Eva Peklaj, 2021, not set Keywords: prehranska priporočila, hranilne snovi, enakovredna živila, prehranski dodatki, prehranjevalne motnje, prehranjenost, živila, telesna aktivnost, zdravstveni nasveti
Published in DiRROS: 16.11.2021; Views: 940; Downloads: 350
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107. Ectomycorrhiza between Scleroderma Areolatum Ehrenb. and Fagus sylvatica L.Tanja Mrak, Katja Kühdorf, Tine Grebenc, Ines Štraus, Marko Bajc, Nada Žnidaršič, Babette Münzenberger, Hojka Kraigher, 2015, published scientific conference contribution abstract Published in DiRROS: 03.11.2021; Views: 800; Downloads: 272
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108. Poročilo 2020 o izvajanju letnega programa dela javnih služb v oljkarstvuMaja Podgornik, Viljanka Vesel, Dunja Bandelj, Bojan Butinar, Elizabeta Bonin, Janko Brajnik, Erika Bešter, Jakob Fantinič, Katja Fičur, Vasja Juretič, Matjaž Prinčič, Vasilij Valenčič, Saša Volk, Milena Bučar-Miklavčič, 2021, other monographs and other completed works Abstract: V okviru javne službe za izvajanje strokovnih nalog v oljkarstvu, so bile v letu 2020 izvedene naloge: selekcija, introdukcija, razmnoževanje sadilnega material, ugotavljanje ustreznih tehnologije za pridelavo oljk ter ugotavljanje vrednosti oljk za predelavo. V poročilu so zbrane morfološke in agronomske lastnosti ter značilnosti oljčnega olja sort 'Buga', 'Črnica' in 'Drobnica', Maurino, Arbequina, Leccione, Itrana, Leccio del corno in 'Štorta' za opazovanja v letu 2019. Predstavljeni so tudi rezultati genotipizacije izbranih sort ter agronomskega vrednotenja in fenofaze različnih sort, ki so zasajene v introdukcijsko-kolekcijskem nasadu Purissima in Šempeter. V poročilu so zbrani podatki tehnoloških poskusov pridelave in predelave; parametri, ki karakterizirajo posamezna sortna olja ter parametri kakovosti oljčnega olja letnika 2020.%Ključne besede: oljkarstvo, oljka, oljčno olje, tehnologija pridelave, ocena letnika, introdukcija, selekcija
Keywords: elektronske knjige
Published in DiRROS: 09.07.2021; Views: 1085; Downloads: 523
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109. Selpercatinib in RET fusion-positive non-small-cell lung cancer (SIREN) : a retrospective analysis of patients treated through an access programOliver Illini, Maximilian J Hochmair, Hannah Fabikan, Christoph Weinlinger, Amanda Tufman, Aurélie Swalduz, Kristina Lamberg, Sayed M. S. Hashemi, Florian Huemer, Anders Vikström, Katja Mohorčič, 2021, original scientific article Abstract: Introduction: Rearranged during transfection (RET) gene fusions are rare genetic drivers in non-small cell lung cancer (NSCLC). Selective RET-inhibitors such as selpercatinib have shown therapeutic activity in early clinical trials; however, their efficacy in the real-world setting is unknown. Methods: A retrospective efficacy and safety analysis was performed on data from RET fusio-%positive NSCLC patients who participated in a selpercatinib access program (named patient protocol) between August 2019 and January 2021. Results: Data from 50 patients with RET fusion-positive advanced NSCLC treated with selpercatinib at 27 centers in 12 countries was analyzed. Most patients were Non-Asian (90%), female (60%), never-smokers (74%), with a median age of 65 years (range, 38-89). 32% of the patients had known brain metastasis at the time of selpercatinib treatment. Overall, 13 patients were treatment-naïve, while 37 were pretreated with a median of three lines of therapy (range, 1-8). The objective response rate (ORR) was 68% [95% confidence interval (CI), 53-81] in the overall population. The disease control rate was 92%. The median progression-free survival was 15.6 months (95% CI, 8.8-22.4) after a median follow-up of 9 months. In patients with measurable brain metastases (n=8) intracranial ORR reached 100%. In total, 88% of patients experienced treatment-related adverse events (TRAEs), a large majority of them being grade 1 or 2. The most common grade >/=3 TRAEs were increased liver enzyme levels (in 10% of patients), prolonged QTc time (4%), abdominal pain (4%), hypertension (4%), and fatigue/asthenia (4%). None of patients discontinued selpercatinib treatment for safety reasons. No new safety concerns were observed, nor where there any treatment-related death. Conclusions: In this real-world setting, the selective RET-inhibitor selpercatinib demonstrated durable systemic and intracranial antitumor activity in RET fusion-positive NSCLC and was well tolerated.
Keywords: non-small cell lung carcinoma -- drug therapy -- genetics, molecular targeted therapy, real-world data, selpercatinib, targeted therapy, tyrosine kinase inhibitor
Published in DiRROS: 16.06.2021; Views: 1325; Downloads: 729
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110. Slovenska priporočila za obravnavo odraslih bolnikov s kronično odpovedjo prebavilNada Rotovnik-Kozjek, Tajda Božič, Katja Kogovšek, Borut Štabuc, Laura Petrica, Karla Berlec, Nataša Puzić Ravnjak, Erik Brecelj, Aleš Tomažič, Sanela Banović, Rada Franko, Milena Kovač-Blaž, Janez Breznik, Davorin Ćeranić, David Drobne, Mojca Gašperin, Tomaž Jurca, Maja Ebert Moltara, Rado Janša, Marjana Turk Jerovšek, Taja Jordan, Tina Kamhi, Primož Karner, Milena Kerin-Povšič, Neža Majdič, Denis Mlakar-Mastnak, Andreja Ocepek, Tadeja Pintar, Stojan Potrč, Nataša Smrekar, Monika Sonc, Maja Šeruga, Petra Tavčar, Igor Virant, 2021, professional article Keywords: kronična odpoved prebavil, zdravljenje, onkološko zdravljenje
Published in DiRROS: 11.06.2021; Views: 1361; Downloads: 364
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