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Query: "author" (Janez Žgajnar) .

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1.
2.
Lower tumour burden and better overall survival in melanoma patients with regional lymph node metastases and negative preoperative ultrasound
Gašper Pilko, Janez Žgajnar, Maja Marolt-Mušič, Marko Hočevar, 2012, original scientific article

Abstract: Background. The purpose of the study was to evaluate the ability of ultrasound(US) and fine needle aspiration biopsy (FNAB) in reducing the numberof melanoma patients requiring a sentinel node biopsy (SNB); to compare the amount of metastatic disease in regional lymph nodes in SNB candidates with clinically uninvolved lymph nodes and of those with US uninvolved lymph nodes; and to compare the overall survival (OS) of both groups. Methods. Between 2000 and 2007, a SNB was successfully performed in 707 patients with melanoma. The preoperative US of the regional lymph node basins was performed in 405 SNB candidates. In 14 of these patients, the US-guided FNAB was positive and they proceeded directly to lymph node dissection. In 391 patients, the preoperative US was either negative (343 patients) or suspicious(48 patients) (US group). In the remaining 316 patients the preoperative US was not performed (non-US group). Results. The proportion of macrometastatic sentinel lymph nodes (SN), number of metastatic lymph nodes per patient and proportion of nonsentinel lymph node metastases were found to be lower in the US group compared to the non-US group. The smaller tumour burden of the US group was reflected in a significantly better OS of patients with SN metastases. Conclusions. The preoperative US of regional lymph nodes spares some patients with melanoma from undergoing a SNB. Patients with regional metastases and a negative preoperative US have a significantly lower tumour burden in comparison to those with clinically negative lymph nodes, which is also reflected in a better OS.
Published in DiRROS: 22.03.2024; Views: 78; Downloads: 27
.pdf Full text (466,54 KB)

3.
Breast cancer risk prediction using Tyrer-Cuzick algorithm with an 18-SNPs polygenic risk score in a European population with below-average breast cancer incidence
Tjaša Oblak, Petra Škerl, Benjamin J. Narang, Rok Blagus, Mateja Krajc, Srdjan Novaković, Janez Žgajnar, 2023, original scientific article

Abstract: Goals: To determine whether an 18 single nucleotide polymorphisms (SNPs) polygenic risk score (PRS18) improves breast cancer (BC) risk prediction for women at above-average risk of BC, aged 40-49, in a Central European population with BC incidence below EU average. Methods: 502 women aged 40-49 years at the time of BC diagnosis completed a questionnaire on BC risk factors (as per Tyrer-Cuzick algorithm) with data known at age 40 and before BC diagnosis. Blood samples were collected for DNA isolation. 250 DNA samples from healthy women aged 50 served as a control cohort. 18 BC-associated SNPs were genotyped in both groups and PRS18 was calculated. The predictive power of PRS18 to detect BC was evaluated using a ROC curve. 10-year BC risk was calculated using the Tyrer-Cuzick algorithm adapted to the Slovenian incidence rate (S-IBIS): first based on questionnaire-based risk factors and, second, including PRS18. Results: The AUC for PRS18 was 0.613 (95 % CI 0.570-0.657). 83.3 % of women were classified at above-average risk for BC with S-IBIS without PRS18 and 80.7 % when PRS18 was included. Conclusion: BC risk prediction models and SNPs panels should not be automatically used in clinical practice in different populations without prior population-based validation. In our population the addition of an 18SNPs PRS to questionnaire-based risk factors in the Tyrer-Cuzick algorithm in general did not improve BC risk stratification, however, some improvements were observed at higher BC risk scores and could be valuable in distinguishing women at intermediate and high risk of BC.
Keywords: early breast cancer, polygenic risk score, risk prediction
Published in DiRROS: 21.03.2024; Views: 85; Downloads: 28
.pdf Full text (1,54 MB)

4.
What is the most common mammographic appearance of T1a and T1b invasive breast cancer?
Maja Podkrajšek, Janez Žgajnar, Marko Hočevar, 2008, original scientific article

Published in DiRROS: 07.03.2024; Views: 99; Downloads: 29
.pdf Full text (204,48 KB)

5.
6.
Sentinel node biopsy in breast cancer
Marko Snoj, Janez Žgajnar, Tadeja Movrin, Rastko Golouh, 2000, published scientific conference contribution abstract

Published in DiRROS: 25.01.2024; Views: 141; Downloads: 31
.pdf Full text (78,79 KB)

7.
Kirurgija raka dojk
Janez Žgajnar, 2023, published professional conference contribution

Keywords: rak dojk, kirurško zdravljenje, kirurgija
Published in DiRROS: 08.01.2024; Views: 125; Downloads: 30
.pdf Full text (175,64 KB)

8.
Presejanje in zgodnje odkrivanje raka
2006, proceedings of professional or unreviewed scientific conference contributions

Published in DiRROS: 07.12.2023; Views: 235; Downloads: 64
.pdf Full text (15,22 MB)

9.
Vloga sekundarnega in terciarnega centra za bolezni dojk
Janez Žgajnar, 2006, professional article

Published in DiRROS: 05.12.2023; Views: 126; Downloads: 46
.pdf Full text (401,18 KB)

10.
Sodobno kirurško zdravljenje raka dojk
Janez Žgajnar, 2004, published scientific conference contribution

Abstract: Izhodišča. Razvoj kirurškega zdravljenja raka dojk je šel v zadnjih treh desetletjih v smer vedno manj obsežne kirurgije. Izkazalo se je, da takšno kirurško zdravljenje varno in ne ogroža preživetja bolnic z rakom dojk. v zadnjem desetletju je bil z uvajanjem novih kirurških metod napravljen nov velik korak k čim manj invazivnemu zdravljenju raka dojk. Diagnostična ali terapevtska kirurška odstranitev netipnih lezij dojk je možna šele po predhodni rentgensko ali ultrazvočno vodeni lokalizaciji. Zaključki. Nova metoda lokalizacije netipnih lezij dojk z radioaktivnim izotopom (ROLL) ima številne prednosti v primerjavi z lokalizacijo z žico: večji delež v zdravo izrezanih rakov v prvi operaciji, manjši delež ponovnih operacij, manjša teža vzorca in zato boljši kozmetični učinek. Biopsija prve bezgavke v regionalni bezgavčni loži omogoča izbiro bolnic, ki v pazdušnih bezgavkah nimajo zasevkovin jim zato ni potrebno odstranjevati vseh pazdušnih bezgavk. Bolnicambrez zasevkov v pazdušnih bezgavkah na ta način prihranimo škodljive posledice odstranitve bezgavk. Doslej opravljene raziskave so pokazale, da nove minimalno invazivne kirurške metode omogočajo učinkovito, varno in s tem racionalno zdravljenje zgodnjega raka dojk.
Published in DiRROS: 01.12.2023; Views: 152; Downloads: 45
.pdf Full text (192,58 KB)

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