21. |
22. 9. MEDNARODNI STROKOVNI POSVET ORGANIZATORJEV PREHRANE IN ZDRAVSTVENO-HIGIENSKEGA REŽIMA SLOVENIJE : »PRIHODNOST ZDRAVJA OTROK«proceedings of peer-reviewed scientific conference contributions (international and foreign conferences) Abstract: "9. mednarodni strokovni posvet organizatorjev prehrane in zdravstveno-higienskega režima Slovenije je potekal 3. in 4. oktobra v Hotelu Radin, v Radencih. Osrednja tema posveta je nosila naslov »Prihodnost zdravja otrok«. Posvet so organizirali Inštitut za sanitarno inženirstvo, Skupnost vrtcev Slovenije – OPZHR Slovenije in Zbornica sanitarnih inženirjev Slovenije."
Published in DiRROS: 23.12.2022; Views: 391; Downloads: 154
 File (518,64 KB) |
23. On the nanoscale structural evolution of solid discharge products in lithium-sulfur batteries using operando scatteringChristian Prehal, Jean-Marc von Mentlen, Sara Drvarič Talian, Alen Vižintin, Robert Dominko, Heinz Amentisch, Lionel Porcar, Stefan A. Freunberger, Vanessa Wood, 2022, original scientific article Published in DiRROS: 14.11.2022; Views: 355; Downloads: 206
Full text (4,04 MB)
This document has many files! More... |
24. |
25. |
26. |
27. |
28. Medullary thyroid carcinoma and associated endocrinopathies in Slovenia from 1995 to 2021Sara Milićević, Mateja Krajc, Ana Blatnik, Barbara Perić, 2022, original scientific article Abstract: Background: Medullary thyroid cancer (MTC) is a rare endocrine tumour that is sporadic in 75% of cases and occurs as a part of inherited cancer syndromes in approximately 25% of cases. The aim of this study was to determine the frequency and type of RET pathogenic variants (PVs) in the Slovenian MTC patient population diagnosed between 1995 and 2021 and to elucidate the full range of associated endocrinopathies. Methods: A retrospective analysis of medical records of 266 MTC patients and their relatives seen in a tertiary centre between 1995 and 2021 was performed. Sequence analysis of exons 10, 11, 13, 14, 15, and 16 of the RET gene was analysed in most patients using Sanger sequencing. From 2017, the entire sequence of RET gene was analysed in most patients using targeted next-generation sequencing. Results: Germline PVs in the RET proto-oncogene were identified in 21.6% probands from 21 different MTC families. Of their tested relatives, 65% (67/103) were RET-positive and 35% (36/103) were RET-negative. PVs were detected in codon 618 and codon 634 in 28.6%, and in codon 790 in 23.8%. The RET-positive group consisted of 52 MTC patients, 13 patients with C cell hyperplasia and 2 individuals with neither. Associated endocrinopathies were diagnosed in 8/21 families: primary hyperparathyroidism (PHPT) in six families and pheochromocytoma (PHEO) in five families. In 62% of RET-positive families (13/21), no associated endocrinopathies were diagnosed. PHEO was most commonly associated with C634R (6/13) and PHPT with C634R (4/7). Hirschsprung’s disease appeared in one patient with RET PV in codon 618. Based on data from the Cancer Registry of Republic of Slovenia, only individual cases of common cancers with well understood environmental risk factors were discovered; lung cancer in 2/21 of families, papillary thyroid cancer in 3/21 of families, cutaneous melanoma in 2/21 of families, cervical cancer in 1/21 families, and lymphoma in 1/21 families. Conclusions: Analysis of prospectively collected MTC cases during a 27-year period revealed that 21.6% of Slovenian patients are RET PV carriers. Sixty-two percent of families had none of the associated endocrinopathies, confirming the thesis that FMTC is the most common presentation. This could suggest using risk-stratified management approaches when screening for PHEO and PHPT in RET PV carriers. However, more studies are needed to evaluate potential genetic risk modifiers as well as safety, improved quality of life, and medical cost reduction in the case of a patient-oriented approach.
Keywords: medullary thyroid carcinoma, multiple endocrine neoplasia, primary hyperparathyroidism
Published in DiRROS: 23.09.2022; Views: 532; Downloads: 248
Full text (248,03 KB)
This document has many files! More... |
29. Plants play a crucial role in the development of soil fungal communities in the remediated substrate after EDTA washing of metal-contaminated soilsIrena Maček, Sara Pintarič, Nataša Šibanc, Tatjana Rajniš, Damjana Kastelec, Domen Leštan, Marjetka Suhadolc, 2022, original scientific article Abstract: In this study, we investigated the importance of plant cover for secondary succession and soil fungal community development in remediated substrates after EDTA washing of metal-contaminated soils. The abundance of the total fungal community, determined by ITS fungal marker genes (Internal Transcribed Spacer region), and root colonisation by arbuscular mycorrhizal (AM) fungi were monitored in two types of soil material (calcareous and acidic) sown with perennial ryegrass (Lolium perenne L.) and without plant cover (bulk soil). Four months after the start of the experiment, the abundance of ITS genes in the soil clearly showed that the presence of plants was the main factor affecting the total fungal community, which increased in the rhizosphere soil in most treatments, while it remained at a low level in the bulk soil (without plants). Interestingly, the addition of environmental inoculum, i.e., rhizosphere soil from a semi-natural meadow, did not have a positive effect on the abundance of the total fungal community. While fungal ITS genes were detected in soils at the end of the first growing season, arbuscular mycorrhizal (AM) structures were scarce in Lolium roots in all treatments throughout the first season. However, in the second season, more than a year after the start of the experiment, AM fungal colonisation was detected in Lolium roots in virtually all treatments, with the frequency of colonised root length ranging from 30% to >75% in some treatments, the latter also in remediated soil. This study demonstrates the importance of plants and rhizosphere in the development and secondary succession of fungal communities in soil, which has important implications for the revitalisation of remediated soils and regenerative agriculture.
Keywords: heavy metals, arbuscular mycorrhiza, remediation, revitalisation, secondary succession, biodiversity, qPCR, toxic metals pollution
Published in DiRROS: 19.09.2022; Views: 634; Downloads: 261
Full text (1,18 MB)
This document has many files! More... |
30. |
