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5. Primary pulmonary choricarcinomaŽiga Snoj, Igor Kocijančič, Erik Škof, 2017, review article Abstract: The aim of the study was to establish whether there are different clinical entities of primary pulmonary choriocarcinoma (PPC) that deserve different diagnostic approach and the most optimal treatment. Patients and methods. A systematic review with PubMed search was conducted to identify studies that reported cases of PPC. The eligibility criteria were histological diagnosis of pulmonary choriocarcinoma and thorough examination of the reproductive organs to exclude potential primary choriocarcinoma in the gonads. Furthermore, to illustrate the review we additionally present a patient referred at our institution. Results. 55 cases (17 men) were included in the review with a median age of 34 years. Women with the history of gestational event showed better survival outcome than women without the history of gestational event. Patients treated with combined modality treatment (surgery and chemotherapy) survived longer than the patients without combined modality treatment. Furthermore, multivariate analysis of prognostic factors showed that the combined modality treatment had independent prognostic significance. Size of the tumour showed significant prognostic influence in univariate and multivariate analysis. Conclusions. PPC is an extreme rarity with variable clinical characteristics and outcome. It is important to capture and treat patients in the early stages of the disease. Women with the history of gestational event may show better survival, therefore genetic examination could help us to predict patient%s prognosis. Surgery followed by adjuvant chemotherapy appears to represent the best treatment for PPC.
Keywords: choriocarcinoma, gestational event, pulmonary tumor, primary horiokarcinom
Published in DiRROS: 10.05.2024; Views: 877; Downloads: 250
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7. CT colonography in detection of colorectal carcinomaAmela Sofić, Šerif Beslić, Igor Kocijančič, Nedžad Šehović, 2010, original scientific article Abstract: Background. Diagnostic methods used in screening and detectingand 2 lipomas,and 2 lipomas, among tumours there were 55 adenocarcinomas and 1 lymphoma. Results showed CT colonography among tumours there were 55 adenocarcinomas and 1 lymphoma. Results showed CTsensitivity to polyps to be 89.7%, barium enema 48.7%, and colonoscopy 94.9%. Sensitivity to tumours of CT colonography colonography colorectal CT barium enema followed by colonoscopy wereand colonoscopy was 100% and of barium enema 94.6%. Specificities and PPV were 100% in all procedures. The performed. After thesensitivity to polyps to be 89.7%, barium enema 48.7%, andcomfort assessment showed CT colonography as the far most comfortable out of three procedures. colonoscopy 94.9%. Sensitivity to tumours of CT colonography procedures a comfort assessment was done in all colonography. The aim of thisand colonoscopy was 100% and of barium enema 94.6%. Specificities and PPV were 100% in all procedures. The study was to establish diagnostic accuracy andpatients. Diagnostic positive comfort assessment showed CT colonography as the far most comfortable out of three procedures. results were verified by the pato-histological examination. Sensitivity, specificity, positive comfort of CT colonography compared carcinoma are digitorectal examination,topredicative value (PPV) and negative predicative value (NPV) were calculated for each procedure.
Keywords: CT colonography, barium enema, colonoscopy, colorectal polyp, colorectal carcinoma
Published in DiRROS: 18.03.2024; Views: 611; Downloads: 196
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9. CT-guided percutaneous transthoracic needle biopsy of lung lesions - 2-year experience at the Institute of radiology in LjubljanaIgor Kocijančič, Ksenija Kocijančič, 2007, original scientific article Abstract: Background. In 1883, Leyden described percutaneous lung biopsy, but it was notuntil 1970s that image guided fine needle chest biopsy gained widespread acceptance. Haaga and Alfidi reported CT-guided thoracic biopsy in 1976. Currently, tissue sampling of a thoracic lesion is indicated when the diagnosis is not obtained by the endobronchial technique and when the cytological diagnosis will modify the stage of the disease or influence the therapeutic strategy. Cytology obtained by small-gauge needle aspiration biopsy confirms the nature of the lesion in 80 - 95% of cases and carry a low incidence of major complications according to the literature. The purpose of this retrospective analysis was to provide basic data about diagnostic accuracy and incidence of pneumothorax and chest tube insertion with respect to percutaneous transthoracic CT-guided needle biopsy of lung lesions. Methods. After positioning of the patient we performed a spiral CT of the thorax with the accordingly placed metal mark, which helped us to set the optimal cutaneous entry point. After that we re-checked the localisation of the lesion and marked the entry point with a pen and clean the surface to keepit sterile. After we applied local anaesthetic subcutaneously, we used coaxial 18G Gallini aspiration biopsy needles with cutting tip for CT- guided aspiration cytologic examination. The length of the needle was chosen according to the distance of the targeted lesion. Results. From January 2005 to January 2007 forty-three patients - 24 men and 19 women who were 26-79 years old (mean +/- SD, 59.8 +/- 10 years) were referred to the Institute of Radiology to undergo the PTNB. One patient was referred twice. Consequently, the hospital records and images of 44 consecutive cases of percutaneous transthoracic fine needle aspiration biopsy procedure were retrospectively analysed. (Abstract truncated at 2000 characters)
Published in DiRROS: 22.02.2024; Views: 787; Downloads: 209
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10. Radiofrequency ablation of lung tumours - new perspective in treatment of lung neoplasmsKsenija Kocijančič, Igor Kocijančič, 2007, original scientific article Abstract: Background. Percutaneous radiofrequency ablation (RFA) is a minimally invasivetechnique used to treat solid tumours. Because of its ability to produce large volume of coagulation necrosis in controlled fashion this technique has been progressively tested as a possible treatment of lung malignancies. Recent clinical studies have shown that RFA enables successful treahnent of relatively small lung malignancies with high rate of complete response and acceptable morbidity and have suggested that the technique could represent a viable alternate or complementary method for patients with non-small cell lung cancer or lung metastases of favourable histotypes who arenot candidates for surgical resection. Conclusions. Initial intenational studies as well as the clinical experience of Institute of Radiology in Clinical Center Ljubljana, although limited, indicated that RFA is mostly welltolerated by patients and also, that it can result in complete necrosis oftargeted lesion. Pneumothorax is most common procedure related complication,occurring in up to 40% of cases, with approx. half of them requiring drainage.
Published in DiRROS: 22.02.2024; Views: 624; Downloads: 182
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