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72. Načrtovanje in gospodarjenje z bukvijo na HrvaškemJuro Čavlović, Igor Anić, 2008, review article Keywords: bukev, Fagus sylvatica, lesna zaloga, nega sestojev, obnova sestojev, Hrvaška, debelinska struktura
Published in DiRROS: 17.11.2020; Views: 1215; Downloads: 365
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73. Uporaba magnetno resonančnega slikanja za raziskave anatomije in vlažnosti lesaMaks Merela, Igor Serša, Urška Mikac, Primož Oven, 2006, original scientific article Abstract: Preverjena je bila uporaba jedrske magnetne resonance (Nmr) za raziskave anatomije in vlažnosti lesa. Na tri metre visoki živi bukvi (Fagus sylvatica L.) smo uporabili 3d spin-echo mr-mikroskopsko tehniko slikanja s prostorsko resolucijo 100 mm in opazovali strukturo odrezane vejice ter spremljali dinamični odziv drevesa na mehansko poškodbo. Za potrditev struktur, vidnih na slikah, smo uporabili svetlobno mikroskopijo. Svetlobna mikroskopija je razkrila anatomsko zgradbo in triletno starost vejice bukve. Slike so jasno razkrile stržen, radialno orientirane večredne ksilemske trakove, traheje ranega lesa, vključno z mejo med ranim in kasnim lesom, kot tudi kambijevo cono s tekočim ksilemskim in floemskim prirastkom. Preučevali smo koncentracijo vode v vejici in globino dehidracije, ki je nastala v 22-tih urah po poškodbi in je segala v globino približno 5 mm od poškodbe. Hitra izguba vlažnosti odseva začetni pasivni odziv prizadetega tkiva. S pomočjo 3d mikroskopije in računalniškega programa Imagej nam je uspelo izdelati prostorski model vode v lesu, ki prikazuje tkiva v vejici z značilno višjo vlažnostjo.
Keywords: MR-mikroskopija, bukev, Fagus sylvatica, živi les, anatomija lesa, vlažnost, porazdelitev vode, mehanska poškodba
Published in DiRROS: 17.11.2020; Views: 1342; Downloads: 391
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76. Idiopathic pulmonary fibrosis in patients with early-stage non-small-cell lung cancer after surgical resectionNežka Hribernik, Igor Požek, Izidor Kern, 2019, original scientific article Abstract: Background. The outcomes of patients with both lung cancer and idiopathic pulmonary fibrosis (IPF) are unfavorable. Therapeutic interventions for lung cancer such as surgery can cause acute exacerbation of IPF (aeIPF). This study aimed to assess the frequency of IPF in a group of patients with early-stage non-small-cell lung cancer (NSCLC) and to report clinical characteristics and outcomes of this cohort of patients. Patients and methods. This observational cohort retrospective study analyzed 641 pathological records of patients after surgical resection of early-stage non-small-cell lung cancer (NSCLC) at University Clinic Golnik from May 2010 to April 2017. Pathological records of NSCLC with coexisting IPF were reviewed. CT scans and biopsy specimens for this group of patients were analyzed by a thoracic radiologist and pathologist, independently. We searched radiological and pathological features of usual interstitial pneumonia (UIP) pattern in this group of patients. We report the clinical characteristics and outcome of this cohort of patients. Results. Out of 641 patients with early-stage NSCLC, only 13 (2.0%) had histologically and radiologically proven coexisting UIP/IPF. Squamous cell carcinoma was the most common type of lung cancer (7/13 patients). The majority of tumors were small size (all being pT1 or pT2), stage I–II (11/13 patients), located in the lower lung lobes (11/13 patients). Almost all patients were current or ex-smokers (11/13 patients). There were two pathologically confirmed fatal cases (15.4%) due to aeIPF in the first two months after radical treatment, one after adjuvant radiotherapy and the other after surgery. Out of 13 patients, one patient had a lung cancer relapse. Conclusions. Frequency of UIP/IPF in surgically treated early stage NSCLC is rather low. Our observational study shows that radical treatment of lung cancer can cause aeIPF with dismal outcome in this group of patients. The standard of care in these mostly elderly patients still remains unresolved.
Keywords: non-small-cell lung cancer, early-stage cancer, idiopathic pulmonary fibrosis, surgery, radiotherapy
Published in DiRROS: 07.10.2020; Views: 1936; Downloads: 860
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77. Dynamic contrast-enhanced MRI of malignant pleural mesothelioma : a comparative study of pharmacokinetic models and correlation with mRECIST criteriaMartina Vivoda Tomšič, Sotirios Bisdas, Viljem Kovač, Igor Serša, Katarina Šurlan Popović, 2019, original scientific article Abstract: BACKGROUND: Malignant pleural mesothelioma (MPM) is a rare and aggressive thoracic malignancy that is difficult to cure. Dynamic contrast-enhanced (DCE) MRI is a functional imaging technique used to analyze tumor microvascular properties and to monitor therapy response. Purpose of this study was to compare two tracer kinetic models, the extended Tofts (ET) and the adiabatic approximation tissue homogeneity model (AATH) for analysis of DCE-MRI and examine the value of the DCE parameters to predict response to chemotherapy in patients with MPM. METHOD: This prospective, longitudinal, single tertiary radiology center study was conducted between October 2013 and July 2015. Patient underwent DCE-MRI studies at three time points: prior to therapy, during and after cisplatin-based chemotherapy. The images were analyzed using ET and AATH models. In short-term follow-up, the patients were classified as having disease control or progressive disease according to modified response evaluation criteria in solid tumors (mRECIST) criteria. Receiver operating characteristic curve analysis was used to examine specificity and sensitivity of DCE parameters for predicting response to therapy. Comparison tests were used to analyze whether derived parameters are interchangeable between the two models. RESULTS: Nineteen patients form the study population. The results indicate that the derived parameters are not interchangeable between the models. Significant correlation with response to therapy was found for AATH-calculated median pre-treatment efflux rate (kep) showing sensitivity of 83% and specificity of 100% (AUC 0.9). ET-calculated maximal pre-treatment kep showed 100% sensitivity and specificity for predicting treatment response during the early phase of the therapy and reached a favorable trend to significant prognostic value post-therapy. CONCLUSION: Both models show potential in predicting response to therapy in MPM. High pre-treatment kep values suggest MPM disease control post-chemotherapy.
Keywords: biomarker, magnetic resonance imaging, mesothelioma, perfusion, response evaluation criteria in solid
tumors, prognosis
Published in DiRROS: 23.09.2020; Views: 1302; Downloads: 956
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78. Smart hardware integration with advanced robot programming technologies for efficient reconfiguration of robot workcellsTimotej Gašpar, Miha Deniša, Primož Radanovič, Barry Ridge, Thiusius Rajeeth Savarimuthu, Aljaž Kramberger, Marc Priggemeyer, Jürgen Rossmann, Florentin Wörgötter, Tatyana Ivanovska, Shahab Parizi, Žiga Gosar, Igor Kovač, Aleš Ude, 2020, original scientific article Published in DiRROS: 10.09.2020; Views: 1646; Downloads: 745
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79. Quantitative determination of PA6 and/or PA66 content in polyamide-containing wastesEma Žagar, Urška Češarek, Ana Drinčić, Simona Sitar, Igor Shlyapnikov, David Pahovnik, 2020, original scientific article Keywords: polymer waste, chemical recycling, microwave chemistry, polyamide content, liquid chromatography
Published in DiRROS: 29.07.2020; Views: 1637; Downloads: 1197
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80. Smernice za diagnostiko in zdravljenje bolnikov z rakom pljučJože Antonič, Tanja Bavčar-Vodovnik, Olga Cerar, Rok Cesar, Anton Crnjac, Andrej Debeljak, Majda Drnovšek, Janez Eržen, Matjaž Fležar, Jože Jerman, Maja Jerše, Peter Kecelj, Izidor Kern, Igor Kocijančič, Viljem Kovač, Nada Rotovnik-Kozjek, Karmen Kramer Vrščaj, Slavica Lahajnar, Ilonka Osrajnik, Tomaž Rott, Andreja A. Schwarzbartl-Pevec, Anja Simonič, Uroš Smrdel, Mihael Sok, Andreja Cirila Škufca Smrdel, Saša Štern, Marjeta Terčelj-Zorman, Nadja Triller, Matjaž Turel, Tomaž Varga, Bojan Veingerl, Barbara Vidergar-Kralj, Stanko Vidmar, Martina Vrankar, Vesna Zadnik, Branko Zakotnik, Jurij Zalar, Anton Zorko, dictionary, encyclopaedia, lexicon, manual, atlas, map Published in DiRROS: 27.05.2020; Views: 2103; Downloads: 582
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