1. Triangular in vivo self-assembling coiled-coil protein origamiSabina Božič Abram, Helena Gradišar, Jana Aupič, Adam Round, Roman Jerala, 2021, original scientific article Keywords: coiled coil, enzyme clustering, biosynthesis, resveratrol, mevalonate
Published in DiRROS: 22.03.2021; Views: 1283; Downloads: 826
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2. Design of coiled-coil protein-origami cages that self-assemble in vitro and in vivoAjasja Ljubetič, Fabio Lapenta, Helena Gradišar, Igor Drobnak, Jana Aupič, Žiga Strmšek, Duško Lainšček, Iva Hafner Bratkovič, Andreja Majerle, Nuša Krivec, Mojca Benčina, Tomaž Pisanski, Tanja Ćirković-Veličković, Adam Round, José María Carazo, Roberto Melero, Roman Jerala, 2017, original scientific article Published in DiRROS: 17.04.2018; Views: 3648; Downloads: 2355
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3. Design principles for rapid folding of knotted DNA nanostructuresVid Kočar, John S. Schreck, Slavko Čeru, Helena Gradišar, Nino Bašić, Tomaž Pisanski, Jonathan P. K. Doye, Roman Jerala, 2016, original scientific article Abstract: Knots are some of the most remarkable topological features in nature. Self-assembly of knotted polymers without breaking or forming covalent bonds is challenging, as the chain needs to be threaded through previously formed loops in an exactly defined order. Here we describe principles to guide the folding of highly knotted single-chain DNA nanostructures as demonstrated on a nano-sized square pyramid. Folding of knots is encoded by the arrangement of modules of different stability based on derived topological and kinetic rules. Among DNA designs composed of the same modules and encoding the same topology, only the one with the folding pathway designed according to the "free-end" rule folds efficiently into the target structure. Besides high folding yield on slow annealing, this design also folds rapidly on temperature quenching and dilution from chemical denaturant. This strategy could be used to design folding of other knotted programmable polymers such as RNA or proteins.
Published in DiRROS: 13.04.2016; Views: 4205; Downloads: 1343
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4. Self-assembled structures composed of single polypeptide comprising at least three coiled-coil forming elements : patentRoman Jerala, Ota Fekonja, Jelka Pohar, Helena Gradišar, Mojca Benčina, Iva Hafner Bratkovič, Robert Bremšak, Špela Miklavič, Urška Jelerčič, Anja Lukan, Tibor Doles, Sabina Božič Abram, Marko Verce, Nika Debeljak, Jožica Friedrich, 2014, patent Keywords: self assembled structures, polipeptide chain, nenostructures
Published in DiRROS: 13.05.2015; Views: 5921; Downloads: 830
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