1. Effect of bleomycin hydrolase expression in tumor tissue on the therapeutic effectiveness of electrochemotherapyJan Bogataj, Urša Lampreht Tratar, Gregor Serša, Maja Čemažar, Aleš Grošelj, Maša Omerzel, 2025, original scientific article Abstract: Electrochemotherapy (ECT) is a cancer treatment that combines application of short electrical pulses with chemotherapy drugs to improve their delivery into tumor cells. Bleomycin is one of the most effective drugs used in ECT, but its success can vary depending on the tumor type. One possible reason is the presence of bleomycin hydrolase (BLMH), an enzyme that inactivates bleomycin. In this study, we measured BLMH levels in different mouse tumor cell lines and tumors grown in animals. Thereafter we compared the levels of BLMH with tumor response to ECT and found a correlation with BLMH content, i.e., tumors with higher BLMH content responded poorly. These findings suggest that levels of BLMH could serve as a predictive marker for ECT effectiveness. Testing for BLMH before treatment may help personalize therapy and identify patients most likely to benefit from ECT.
Keywords: electrochemotherapy, bleomycin hydrolase, predictive biomarker, murine models
Published in DiRROS: 20.04.2026; Views: 140; Downloads: 103
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2. Phase I trial of phIL12 plasmid intratumoral gene electrotransfer in patients with basal cell carcinoma in head and neck regionPrimož Strojan, Tanja Jesenko, Maša Omerzel, Črt Jamšek, Aleš Grošelj, Urša Lampreht Tratar, Boštjan Markelc, Gorana Gašljević, Alojz Ihan, Franc Smrekar, Matjaž Peterka, Maja Čemažar, Gregor Serša, 2025, original scientific article Keywords: phase I clinical trial, phIL12 plasmid, interleukin-12, gene electrotransfer, basal cell carcinoma
Published in DiRROS: 13.04.2026; Views: 150; Downloads: 109
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3. Bleomycin electrosclerotherapy (BEST) : mechanistic parallels to electrochemotherapy, experimental models, and unresolved questionsBarbara Lisec, Maja Čemažar, Tobian Muir, Maša Omerzel, Tanja Jesenko, Boštjan Markelc, Aleš Grošelj, Rok Dežman, Miha Štabuc, Dimitrij Kuhelj, Gregor Serša, 2026, review article Keywords: vascular malformations, bleomycin electrosclerotherapy, BEST, electrochemotherapy
Published in DiRROS: 01.04.2026; Views: 232; Downloads: 127
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4. Učinek kombinacije elektrokemoterapije in anti-pd-1 imunoterapije pri mišjih modelih tumorjev z različnim imunskim statusomSimona Kranjc Brezar, Maša Omerzel, Urša Lampreht Tratar, Tanja Jesenko, Barbara Lisec, Gregor Serša, Maja Čemažar, 2025, published scientific conference contribution abstract Keywords: eksperimentalna onkologija, imunoterapija, elektrokemoterapija
Published in DiRROS: 18.03.2026; Views: 295; Downloads: 128
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5. Vzpostavitev elektroprenosa sistema transpomnožujočih mRNA na modelu mišjega melanoma B16-F10 in vitro in in vivoJaka Vrevc Žlajpah, Urška Kamenšek, Urša Lampreht Tratar, Maja Čemažar, Gregor Serša, Katja Uršič Valentinuzzi, 2025, published scientific conference contribution abstract Keywords: elektrokemoterapija, eksperimentalna onkologija, melanom
Published in DiRROS: 18.03.2026; Views: 241; Downloads: 81
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6. Elektrokemoterapija z bleomicinom, cisplatinom ali oksaliplatinom na mišjih tumorskih modelih : od ablacije do vakcinacije in situKatja Uršič Valentinuzzi, Urška Kamenšek, Simona Kranjc Brezar, Chloe Heranney, Tilen Komel, Simon Buček, Maja Čemažar, Gregor Serša, 2025, published scientific conference contribution abstract Keywords: elektrokemoterapija, eksperimentalna onkologija, miši
Published in DiRROS: 11.03.2026; Views: 322; Downloads: 112
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10. Vzpostavitev in karakterizacija mišjega tumorskega modela za raziskave s HPV povezanega raka glave in vratuŽiva Pišljar, Maja Čemažar, Boštjan Markelc, Gregor Serša, Simona Kranjc Brezar, Tanja Jesenko, 2024, published scientific conference contribution abstract Keywords: elektroprenos genov, eksperimentalna onkologija, onkologija
Published in DiRROS: 25.02.2026; Views: 373; Downloads: 100
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