1. Bleomycin electrosclerotherapy (BEST) : mechanistic parallels to electrochemotherapy, experimental models, and unresolved questionsBarbara Lisec, Maja Čemažar, Tobian Muir, Maša Omerzel, Tanja Jesenko, Boštjan Markelc, Aleš Grošelj, Rok Dežman, Miha Štabuc, Dimitrij Kuhelj, Gregor Serša, 2026, review article Keywords: vascular malformations, bleomycin electrosclerotherapy, BEST, electrochemotherapy
Published in DiRROS: 01.04.2026; Views: 147; Downloads: 66
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2. Vzpostavitev mišjega modela trojno negativnega raka dojk 4T1 za proučevanje cirkulirajočih tumorskih celic in procesa zasevanjaVeronika Škrjanc, Simona Kranjc Brezar, Maja Čemažar, Boštjan Markelc, Cvetka Grašič-Kuhar, Simona Miceska, Veronika Kloboves-Prevodnik, Tanja Jesenko, 2025, published scientific conference contribution abstract Keywords: citopatologija, diagnostična dejavnost, onkologija
Published in DiRROS: 18.03.2026; Views: 156; Downloads: 78
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3. Učinki obsevanja mišjih tumorjev na naučeno imunost in naravne celice ubijalkeTim Božič, Boštjan Markelc, Barbara Lisec, Iva Šantek, Simona Kranjc Brezar, Živa Pišljar, Tanja Jesenko, Maja Čemažar, 2025, published scientific conference contribution abstract Keywords: eksperimentalna onkologija, miši, celice ubijalke
Published in DiRROS: 11.03.2026; Views: 182; Downloads: 79
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7. Protitumorsko delovanje utišanja transkripcijskega faktorja E2F1 na modelu humanega kolorektalnega karcinoma : in vitro in in vivo spoznanjaSimona Kranjc Brezar, Tanja Jesenko, Monica Cazzato, Živa Pišljar, Boštjan Markelc, Tim Božič, Gabriele Grassi, Maja Čemažar, 2024, published scientific conference contribution abstract (invited lecture) Keywords: rak debelega črevesa in danke, eksperimentalna onkologija, onkologija
Published in DiRROS: 25.02.2026; Views: 243; Downloads: 63
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8. Vzpostavitev in karakterizacija mišjega tumorskega modela za raziskave s HPV povezanega raka glave in vratuŽiva Pišljar, Maja Čemažar, Boštjan Markelc, Gregor Serša, Simona Kranjc Brezar, Tanja Jesenko, 2024, published scientific conference contribution abstract Keywords: elektroprenos genov, eksperimentalna onkologija, onkologija
Published in DiRROS: 25.02.2026; Views: 269; Downloads: 71
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10. Chemokine CCL5 overexpression combined with radiotherapy modulates Th1-mediated immune response and leads to significant tumor growth delay in mouse tumor modelsTim Božič, Iva Šantek, Živa Pišljar, Simona Kranjc Brezar, Gregor Serša, Boštjan Markelc, Maja Čemažar, 2026, original scientific article Abstract: This study investigated the antitumor efficacy of chemokine CCL5 gene therapy using gene electrotransfer (GET) in combination with radiotherapy (RT) in solid murine tumors CT26 and 4T1. In vitro, CT26 and 4T1 tumor cells transfected with plasmid DNA (pDNA) encoding CCL5 induced migration of RAW264.7 macrophages. In vivo, CCL5 overexpression achieved via GET of pDNA encoding CCL5 led to increased splenocyte infiltration in dorsal window chamber models. When combined with RT, GET of pDNA encoding CCL5 shifted the tumor cytokine profile toward a proinflammatory state, with elevated Ifn-γ, Cxcl9, Cxcl10, and Il-12α. Although CD8 + and CD4 + T cells were reduced post-treatment, due to radiation-induced cell death, the combination of GET of pDNA encoding CCL5 and RT significantly delayed tumor growth in both models. In 4T1 tumors, this delay was also significant compared to the equivalent treatment with GET of control pDNA. These findings support GET of pDNA encoding CCL5 combined with RT as a strategy to enhance immune-mediated tumor control.
Keywords: chemokines, gene electrotransfer, gene therapy, mouse, radiotherapy
Published in DiRROS: 13.02.2026; Views: 426; Downloads: 100
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