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1.
Combined toxic effects of BPA and its two analogues BPAP and BPC in a 3D HepG2 cell model
Martina Štampar, Tim Ravnjak, Ana-Marija Domijan, Bojana Žegura, 2023, original scientific article

Abstract: Bisphenol A (BPA) is one of the most commonly used substances in the manufacture ofvarious everyday products. Growing concerns about its hazardous properties, including endocrinedisruption and genotoxicity, have led to its gradual replacement by presumably safer analogues inmanufacturing plastics. The widespread use of BPA and, more recently, its analogues has increasedtheir residues in the environment. However, our knowledge of their toxicological profiles is limitedand their combined effects are unknown. In the present study, we investigated the toxic effectscaused by single bisphenols and by the combined exposure of BPA and its two analogues, BPAP andBPC, after short (24-h) and prolonged (96-h) exposure in HepG2 spheroids. The results showed thatBPA did not reduce cell viability in HepG2 spheroids after 24-h exposure. In contrast, BPAP andBPC affected cell viability in HepG2 spheroids. Both binary mixtures (BPA/BPAP and BPA/BPC)decreased cell viability in a dose-dependent manner, but the significant difference was only observedfor the combination of BPA/BPC (both at 40μM). After 96-h exposure, none of the BPs studiedaffected cell viability in HepG2 spheroids. Only the combination of BPA/BPAP decreased cellviability in a dose-dependent manner that was significant for the combination of 4μM BPA and 4μMBPAP. None of the BPs and their binary mixtures studied affected the surface area and growth ofspheroids as measured by planimetry. In addition, all BPs and their binary mixtures studied triggeredoxidative stress, as measured by the production of reactive oxygen species and malondialdehyde,at both exposure times. Overall, the results suggest that it is important to study the effects of BPsas single compounds. It is even more important to study the effects of combined exposures, as thecombined effects may differ from those induced by single compounds.
Keywords: BP analogues, hepatic in vitro 3D cell model, combined exposure, viability, oxidative stress, toxicology
Published in DiRROS: 12.07.2024; Views: 32; Downloads: 16
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2.
The association between day-to-day stress experiences, recovery, and work engagement among office workers in academia : an Ecological Momentary Assessment study
Larissa Bolliger, Ellen Baele, Elena Colman, Gillian Debra, Junoš Lukan, Mitja Luštrek, Dirk De Bacquer, Els Clays, 2023, original scientific article

Abstract: Objectives. This study aimed to investigate the associations between day-to-day work-related stress exposures (i.e., job demands and lack of job control), job strain, and next-day work engagement among office workers in academic settings. Additionally, we assessed the influence of psychological detachment and relaxation on next-day work engagement and tested for interaction effects of these recovery variables on the relationship between work-related stressors and next-day work engagement. Methods. Office workers from two academic settings in Belgium and Slovenia were recruited. This study is based on an Ecological Momentary Assessment (EMA) with a 15-working day data collection period using our self-developed STRAW smartphone application. Participants were asked repeatedly about their work-related stressors, work engagement, and recovery experiences. Fixed-effect model testing using random intercepts was applied to investigate within- and between-participant levels. Results. Our sample consisted of 55 participants and 2710 item measurements were analysed. A significant positive association was found between job control and next-day work engagement (β = 0.28, p < 0.001). Further, a significant negative association was found between job strain and next-day work engagement (β = −0.32, p = 0.05). Furthermore, relaxation was negatively associated with work engagement (β = −0.08, p = 0.03). Conclusions. This study confirmed previous results, such as higher job control being associated with higher work engagement and higher job strain predicting lower work engagement. An interesting result was the association of higher relaxation after the working day with a lower next-day work engagement. Further research investigating fluctuations in work-related stressors, work engagement, and recovery experiences is required.
Keywords: work-related stress, stress exposure, work engagement, office workers, academia
Published in DiRROS: 04.05.2023; Views: 483; Downloads: 217
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