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1334. Outgassing behaviour during highly explosive basaltic eruptionsEmily C. Bamber, Giuseppe La Spina, Fabio Arzilli, Margherita Polacci, Lucia Mancini, Mattia de’ Michieli Vitturi, Daniele Andronico, Rosa Anna Corsaro, Mike R. Burton, 2024, original scientific article Abstract: Explosivity of basaltic eruptions is related to the efficiency in which exsolved gas can separate from the melt during ascent, which is controlled by magma permeability. However, basaltic pyroclasts from eruptions of varying explosivity can show similar permeability, indicating a possible complex relationship between permeability, outgassing and eruptive style. Here, we provide 3D measurements of basaltic pyroclasts using X-ray microtomography. We investigate the role of permeability and outgassing on magma ascent dynamics by using a numerical conduit model. Among the permeable parameters, bubble number density and friction coefficient largely affect explosivity. However, for fast ascending basaltic magmas, gas-melt coupling is maintained independent of magma permeability. In this case, magma storage conditions may determine eruptive style, driving rapid magma ascent, crystallisation and bubble nucleation, producing a highly explosive eruption. Monitoring parameters which reveal pre-eruptive conditions may assist hazard mitigation, particularly for basaltic systems which exhibit a wide range in eruptive style.
Keywords: natural hazards, petrology, volcanology
Published in DiRROS: 12.01.2024; Views: 276; Downloads: 153
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1335. Možnosti rabe lesa listavcev v slovenskem biogospodarstvu : vsebinsko poročiloPeter Prislan, Špela Ščap, Matevž Triplat, Nike Krajnc, Luka Krajnc, Domen Arnič, Aleš Straže, Dominika Gornik Bučar, Jože Kropivšek, Luka Juvančič, 2023, final research report Keywords: potenciali gozdov, raba lesa listavcev, lesno-predelovalna industrija, gozdno lesne verige vrednosti, tehnologije predelave lesa, biogospodarstvo, makroekonomska analiza
Published in DiRROS: 11.01.2024; Views: 327; Downloads: 114
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1336. Exploration of macromolecular phenotype of human skeletal muscle in diabetes using infrared spectroscopyBarbara Zupančič, Chiedozie Kenneth Ugwoke, Mohamed Elwy Abdelmonaem, Armin Alibegović, Erika Cvetko, Jože Grdadolnik, Anja Šerbec, Nejc Umek, 2023, original scientific article Abstract: Introduction: The global burden of diabetes mellitus is escalating, and more efficient investigative strategies are needed for a deeper understanding of underlying pathophysiological mechanisms. The crucial role of skeletal muscle in carbohydrate and lipid metabolism makes it one of the most susceptible tissues to diabetes-related metabolic disorders. In tissue studies, conventional histochemical methods have several technical limitations and have been shown to inadequately characterise the biomolecular phenotype of skeletal muscle to provide a holistic view of the pathologically altered proportions of macromolecular constituents. Materials and methods: In this pilot study, we examined the composition of five different human skeletal muscles from male donors diagnosed with type 2 diabetes and non-diabetic controls. We analysed the lipid, glycogen, and collagen content in the muscles in a traditional manner with histochemical assays using different staining techniques. This served as a reference for comparison with the unconventional analysis of tissue composition using Fourier-transform infrared spectroscopy as an alternative methodological approach. Results: A thorough chemometric post-processing of the infrared spectra using a multi-stage spectral decomposition allowed the simultaneous identification of various compositional details from a vibrational spectrum measured in a single experiment. We obtained multifaceted information about the proportions of the different macromolecular constituents of skeletal muscle, which even allowed us to distinguish protein constituents with different structural properties. The most important methodological steps for a comprehensive insight into muscle composition have thus been set and parameters identified that can be used for the comparison between healthy and diabetic muscles. Conclusion: We have established a methodological framework based on vibrational spectroscopy for the detailed macromolecular analysis of human skeletal muscle that can effectively complement or may even serve as an alternative to histochemical assays. As this is a pilot study with relatively small sample sets, we remain cautious at this stage in drawing definitive conclusions about diabetes-related changes in skeletal muscle composition. However, the main focus and contribution of our work has been to provide an alternative, simple and efficient approach for this purpose. We are confident that we have achieved this goal and have brought our methodology to a level from which it can be successfully transferred to a large-scale study that allows the effects of diabetes on skeletal muscle composition and the interrelationships between the macromolecular tissue alterations due to diabetes to be investigated.
Keywords: diabetes mellitus, skeletal muscle, metabolism, macromulecular composition, infrared spectroscopy, multivariate analysis, histochemical assays
Published in DiRROS: 11.01.2024; Views: 385; Downloads: 121
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1338. Importance of surgery in the multimodality treatment for small cell lung cancer (SCLC)A... Schamanek, K... Karrer, Janez Orel, Janez Eržen, Bogomir Hrabar, Metka Klevišar, Miha Debevec, Tomaž Rott, 1994, original scientific article Published in DiRROS: 11.01.2024; Views: 258; Downloads: 78
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