1201. A correlation of NK cytolitic test and BLT esterase test in determining activity of NK cells, stimulated by tumor target cellsAlojz Ihan, 1999, original scientific article Abstract: We examined the granule exocytosis in natural killer (NK) cells by measuring N-benzyloxycarboxy-L-lysine esterase activity. As a source of NK cells we usedbuffy-coat isolated NK cells or peripheral blood lymphocytes (PBL). The exocytosis was triggered by incubating cells with ionomycin/PMA or by NK cell susceptible tumour target cells K562. When we stimulated purified NK cells with tumour target cells, a close correlation (Corr=0.84) of cytolitic NK testresults and BLT test results was obtained. We may conclude that BLT test can provide a valuable tool to discriminate further NK cell deficiency in patients with low cytolitic NK test results.
Published in DiRROS: 22.01.2024; Views: 204; Downloads: 73
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1202. Predictive assays of tumor response to chemo and radiotherapyMaja Čemažar, 1999, review article Abstract: Predstavljeni so testi za napovedovanje izida zdravljenja tumorjev po kemo- inradioterapiji in poškodb normalnih tkiv po radioterapiji. Pregled je osredotočen na tiste teste, pri katerih je treba celice gojiti v pogojih in vitro. Poleg tega članek obravnava tudi korelacijo med napovednimi testi in izidom zdravljenja različnih vrst raka ter poškodbami normalnih tkiv.
Published in DiRROS: 22.01.2024; Views: 237; Downloads: 64
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1203. Use of steel slag for the synthesis of belite-sulfoaluminate clinkerLea Žibret, Martina Cvetković, Maruša Mrak, Mojca Loncnar, Andrej Ipavec, Sabina Dolenec, 2020, published scientific conference contribution Abstract: Belite-sulfoaluminate (BCSA) cements are low-carbon mineral binders, which require low energy consumption and allow the incorporation of various secondary raw materials in the clinker raw meal. In this study two types of unprocessed steel slags, coming from stainless steel production, were incorporated in the BCSA clinkers. The clinker phase composition, clinker reactivity, and the compressive strength of the cement were studied to evaluate the possible use of the slag in BCSA clinkers. The cement clinkers were synthesized by using natural raw materials, white titanogypsum, mill scale, as well as two different steel slags: (i) EAF S slag, which is a by-product of melting the recycled steel scrap in an electric arc furnace, and (ii) la dle slag as a by-product of the processes of secondary metallurgy, in various quantities. Raw mixtures with two different targeted phase compositions varying in belite, calcium sulfoaluminate and ferrite phases were sintered at 1250 °C. Clinker phases were determined by Rietveld quantitative phase analysis, while their distribution, morphology and incorporation of foreign ions in the phases were studied by SEM/EDS analysis. The clinker reactivity was determined by isothermal calorimetry. BCSA cements were prepared by adding titanogypsum. The compressive strength of the cement pastes was determined after 7 days of hydration. The presence of a predicted major clinker phases was confirmed by Rietveld analysis, however periclase was also detected. Microscopy revealed subhedral grains of belite and euhedral grains of calcium sulfoaluminate phases, while ferrite occurred as an interstitial phase. The results showed differences in the microstructure and reactivity of the clinker and cement, which can be attributed to varying amounts of ettringite due to different slag types
Keywords: belite-sulfoaluminate cement, cement clinker, steel slags, clinker microstructure, cement reactivity
Published in DiRROS: 19.01.2024; Views: 323; Downloads: 125
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1204. Appropriate sound insulation of facades as a measure to ensure acceptable acoustic comfort in residential buildingsMihael Ramšak, 2020, published scientific conference contribution Abstract: Wherever possible, the environment with residential buildings should be protected from the effects of noise sources by environmental noise reduction measures. If such measures cannot reduce the noise level in the environment to an acceptable level, acceptable acoustic comfort in the residential buildings shall be ensured by adequate sound insulation of the facades, which is the main topic of this paper. The paper outlines some of the criteria for providing good acoustic comfort in the residential buildings, on the basis of which the conditions and necessary measures for providing sufficient sound insulation of the facade elements are discussed. Since, in addition to the noise from the environment, the acoustic comfort in apartments is also affected by the noise from adjacent apartments in the building, the link between the sound insulation performance of facades and audibility of the speech noise form adjacent apartments is also discussed.
Keywords: acoustic comfort, traffic noise, soun levels, sound insulation
Published in DiRROS: 19.01.2024; Views: 299; Downloads: 109
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1205. Extending BIM for air quality monitoringMichael Nicolas Mrissa, Jan Vcelak, László Hajdu, Balázs Dávid, Miklós Ferenz Krész, Jakub Michal Sandak, Anna Malgorzata Sandak, Rok Kanduti, Monika Varkonji, Anja Jutraž, Katja Malovrh Rebec, 2020, published scientific conference contribution Abstract: As we spend more than 90% of our time inside buildings, indoor environmental quality is a major concern for healthy living. Recent studies show that almost 80% of people in European countries and the United States suffer from SBS (Sick Building Syndrome), which affects physical health, productivity and psychological well-being. In this context, environmental quality monitoring provides stakeholders with crucial information about indoor living conditions, thus facilitating building management along its lifecycle, from design, construction and commissioning to usage, maintenance and end-of-life. However, currently available modelling tools for building management remain limited to static models and lack integration capacities to efficiently exploit environmental quality monitoring data. In order to overcome these limitations, we designed and implemented a generic software architecture that relies on accessible Building Information Model (BIM) attributes to add a dynamic layer that integrates environmental quality data coming from deployed sensors. Merging sensor data with BIM allows creation of a digital twin for the monitored building where live information about environmental quality enables evaluation through numerical simulation. Our solution allows accessing and displaying live sensor data, thus providing advanced functionality to the end-user and other systems in the building. In order to preserve genericity and separation of concerns, our solution stores sensor data in a separate database available through an application programming interface (API), which decouples BIM models from sensor data. Our proof-of-concept experiments were conducted with a cultural heritage building located in Bled, Slovenia. We demonstrated that it is possible to display live information regarding environmental quality (temperature, relative humidity, CO2, particle matter, light) using Revit as an example, thus enabling end-users to follow the conditions of their living environment and take appropriate measures to improve its quality
Keywords: Building Information Model, internet of things, environmental quality monitoring, healthy living
Published in DiRROS: 19.01.2024; Views: 296; Downloads: 130
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1206. Measurement of the chloride resistance of environmentally friendly and durable concreteAlisa Machner, Marie Helene Bjørndal, Aljoša Šajna, Lucija Hanžič, Yushan Gu, Benoit Bary, Klaartje De Weerdt, 2020, published scientific conference contribution Abstract: The increasing demand for concrete and thereby Portland cement, creates the need for novel low-clinker Portland composite cements. Concretes prepared with such novel composite cements need to show similar or even improved durability compared to concrete prepared with commonly used Portland composite cements. This study represents a part of the EnDurCrete project that focuses on the durability of concrete produced with novel low-clinker cements, containing high-value industrial by-products. More specifically, we investigated the chloride ingress resistance of such concrete. Concrete cylinders were submitted to chloride ingress by bulk diffusion. The chloride ingress resistance was investigated on concrete samples by %XRF scanning and chloride titration. In addition, the chloride binding capacity of these novel binders was investigated on paste samples by determining chloride binding isotherms for both binders. In the next step of the project, these experimental results will be matched with an advanced model, which is being developed within the project. By combining modelling with experimental verification, we aim to reach a better understanding of the fundamental chloride ingress mechanisms acting on novel types of concrete. The overall goal of the work is to produce a concrete with lower cost, lower environmental footprint and with verified similar or improved durability.
Keywords: chloride ingress, durability, novel binders, Low C02, sustainability, concrete
Published in DiRROS: 19.01.2024; Views: 315; Downloads: 127
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1207. Molecular alterations induced in drug-resistant cellsMaja Osmak, 1998, original scientific article Abstract: The major obstacle to the ultimate success in cancer therapy is the ability oftumor cells to develop resistance to anticancer drugs. Several molecular mechanisms have been suggested to be involved in drugresistance: a) decrease in the intracellular drug accumulation (increased activity of membrane transporters such as P-glycoprotein or multidrug-resistance-associated protein), b) changes in intracellular detoxification system (increased concentrations of glutathione or metallothioneins, or increased activity of related enzymed), c) alteration in nuclear enzymes (enhanced DNA repair and/orbetter tolerance of DNA damage, decreased acitivty of topoisomerases), d) altered expression of oncogenes (inducing increased level of protective molecules in cells or the inhibition of apoptosis). Drug resistance is a multifactorial phenomenon. The complexity of molecular alterations in drug-resistant cells is and will stay the main problem for the successful treatment of cancer.
Published in DiRROS: 19.01.2024; Views: 266; Downloads: 57
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1208. Influence of UV-B radiation on Norway spruce seedlings (Picea abies (L.) Karst.)Jože Bavcon, Nada Gogala, Alenka Gaberščik, 1998, original scientific article Abstract: On the basis of the hypothesis that the ultraviolet radiation is one of the main causes for damage at higher altitudes, we have monitored the effect of UVradiation on Norway spruce for two and a half years. The influence of UV-B radiation on Picea abies (L). Karst.seedlings cultured in pots in open greenhouses was examined by measuring photochemical efficiency of photosystem II, changes in chlorophyll a, b, and changes in anthocyanins. The seedlings were grown in a mixture of peat and vermiculite (4:1). We used Osram ultravitaluks bulbs as a source of UV-B radiation. In the experiment plants were treated with 21.24+-3.5 kJ/m2 and 31.9+-2.5 KJ/m2. The control plants were grown under ambient conditions in the greenhouse without artificial source of UV-B radiation. The mean yearly values were as high as 11.5+-5.2 kJ/m2. The photochemical efficiency of photosystem II (PS II) in experimental plants did not vary during the experiment. It showed obvious decrease in the winter period, due to low temperatures and physical draught. The decrease in chlorophyll a and b, was already detected after one year of treatment with simultaneous changes in a/b ration. An increase of anthocyanins amount was detected as well.
Published in DiRROS: 19.01.2024; Views: 257; Downloads: 73
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1209. Apparatus for positron emission tomographyMarko Starič, Samo Korpar, Erik Margan, Marko Šifrar, Aleš Stanovnik, Nataša Budihna, Metka Milčinski, Boris Šket, 1998, original scientific article Published in DiRROS: 19.01.2024; Views: 224; Downloads: 52
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1210. Bone marrow toxicity and antitumor action of adriamycin in relation to the antioxidant effects of melatoninValentina Rapozzi, Laura Perissin, Sonja Zorzet, Marina Comelli, Irene Mavelli, Marjeta Šentjurc, Alja Pregelj, Milan Valter Schara, Tullio Giraldi, 1998, original scientific article Published in DiRROS: 19.01.2024; Views: 236; Downloads: 55
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