221. Coronavirus disease 2019-associated thrombotic microangiopathy : a single-center experienceMarija Malgaj Vrečko, Andreja Aleš Rigler, Špela Borštnar, Željka Večerić-Haler, 2024, original scientific article Keywords: thrombotic microangiopathy, thrombotic thrombocytopenic purpura, atypical hemolytic uremic syndrome, COVID-19, acute kidney injury, pathophysiology
Published in DiRROS: 02.12.2025; Views: 141; Downloads: 60
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222. Taxonomy of digital twins for power gridsTanja Pavleska, 2026, original scientific article Abstract: Digital twins (DTs) are increasingly adopted in the energy sector, yet existing conceptual frameworks and maturity models remain largely generic, limiting their usefulness for power grid applications with stringent requirements for resilience, security, and lifecycle integration. This paper proposes an upgraded taxonomy of DTs tailored to power grid systems, extending earlier generic frameworks and aligning them with the ISO/IEC30186:2025 maturity model. The taxonomy introduces domain-specific dimensions, including cyber-physical security integration, intelligence level, and multi-layered data architectures, while ensuring compatibility with internationally standardized maturity aspects. A comprehensive literature analysis and co-occurrence study underpin the revisions, ensuring both methodological rigor and relevance to current research and practice. The taxonomy’s analytical and practical value is demonstrated through its application to three real-world DT use cases: KOEN (generation-focused), Elvia (distribution-focused), and Bentley OpenUtilities (lifecycle-integrated). Comparative benchmarking across these cases highlights both commonalities and context-dependent maturity profiles, confirming that DT maturity is not absolute but shaped by organizational objectives, technical architectures, and sectoral priorities. The taxonomy also enables scenario-based reasoning and role-specific insights, supporting cybersecurity analysis, operational decision-making, and business risk evaluation. By combining academic rigor, sector-specific focus, and alignment with international standards, the proposed taxonomy offers a replicable framework for assessing and improving DT maturity in power grids. An interactive tool, openly available on GitHub, further supports its practical application by enabling benchmarking, visualization, and recommendations. In this way, the work contributes both to scholarly discourse on DT conceptualization and to the practical adoption of maturity frameworks by utilities, regulators, and technology providers.
Keywords: taxonomy, power grids, digital twin, co-occurrence analysis
Published in DiRROS: 02.12.2025; Views: 76; Downloads: 36
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224. A pilot study on the replacement of fibrinogen with fibrinogen concentrates during therapeutic plasma exchange with mild to moderate bleeding risk : a comparison with fresh frozen plasma and albumin replacementMatej Zrimšek, Jakob Gubenšek, Andreja Marn-Pernat, 2024, original scientific article Abstract: Background: Therapeutic plasma exchange (TPE) removes coagulation factors and leads to depletion coagulopathy. The aim of the study was to compare hemostasis between TPE procedures without coagulation factor replacement (electrolyte group), the partial replacement of fibrinogen with fibrinogen concentrates (fibrinogen group) and partial coagulation factors replacement with fresh frozen plasma (partial FFP group). Methods: A total of 73 TPE procedures in patients with fibrinogen levels 1–2 g/L were divided into three study groups depending on clinically estimated bleeding risk. Standard coagulation and ROTEM® tests were performed before and after TPE. Results: Fibrinogen levels before TPE (p = 0.88) and after TPE (p = 0.33) were comparable between the fibrinogen and partial FFP groups. INR and ROTEM® parameters reflected moderately worse hemostasis after TPE with fibrinogen-only replacement compared to partial FFP replacement, which could result in increased bleeding risk. In the electrolyte group, most laboratory tests confirmed the most deranged hemostasis after TPE, as compared to fibrinogen or partial FFP replacement. A mild allergic reaction to FFP infusion was noted during one TPE. No clinically significant bleeding occurred in any of the study groups. Conclusions: Fibrinogen concentrate supplementation and partial FFP replacement can both maintain fibrinogen levels > 1 g/L after TPE, but modest differences in classical coagulation tests and bedside ROTEM® tests favor FFP replacement (NCT03801135).
Keywords: therapeutic plasma exchange, coagulation, fibrinogen concentrate, fresh frozen plasma, bleeding risk
Published in DiRROS: 01.12.2025; Views: 123; Downloads: 61
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225. Complications on the feeding artery after an arterio-venous fistula closure in patients after kidney transplantation : a national cohort studyMatej Zrimšek, Barbara Vajdič Trampuž, Matija Jelenc, Juš Kšela, Jakob Gubenšek, 2025, original scientific article Abstract: Background: Arteriovenous fistulas (AVFs) in kidney transplant recipients are sometimes closed, either as a policy or due to complications. We collected data on the incidence of complications after AVF closure in a national cohort of transplanted patients. Methods: Patients who received a kidney transplant between 2000 and 2015 and had a functional AVF that was later ligated or extirpated were included. Medical records were searched for arterial complications on the arm with the closed AVF. Furthermore, all patients who were still alive in January 2023 were invited for a follow-up arterial ultrasound exam. Results: Sixty patients were included; mean follow-up was 9.3 ± 3.8 years. There were five (8% cumulative incidence) patients with symptomatic arterial thrombosis and three (5% incidence) with a symptomatic feeding artery aneurysm. Prospective ultrasound exams were performed in 50 patients; the mean diameter of the brachial artery was almost doubled on the arm with the closed AVF (8.1 ± 3.2 versus 4.7 ± 0.7 mm; P < .001). Additional asymptomatic complications were found in nine patients (18% incidence): seven cases (14% incidence) of arterial thrombosis, some extending up to the axillary artery, and three (6% incidence) brachial artery aneurysms. All patients in whom the thrombosis spread to the brachial artery had large brachial arteries (>10 mm) or an aneurysm. Conclusion: We observed a high cumulative incidence of arterial thrombosis (20%) and brachial artery aneurysms (10%), sometimes developing several years after AVF closure. These complications should be taken into account when contemplating closure of a well-developed AVF and an AVF-preserving approach with flow reduction surgery might be preferred in some cases.
Keywords: kidney transplantation, arterial thrombosis, arteriovenous fistula, complications, true brachial artery aneurysm, ultrasound exam
Published in DiRROS: 01.12.2025; Views: 186; Downloads: 55
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226. Haptoglobin as a novel predictor of visceral involvement and relapse in adult IgAV patientsMatija Bajželj, Nina Visočnik, Katjuša Mrak Poljšak, Matjaž Hladnik, Katja Lakota, Alojzija Hočevar, 2025, original scientific article Abstract: Introduction: IgA vasculitis (IgAV) can present as skin-limited or systemic disease, which can be severe in adults. Predictive markers for visceral involvement are suboptimal. Considering haptoglobin's role as an acute phase reactant, we evaluated whether its differential expression in IgAV patients' skin and leukocytes is also reflected systemically in a larger cohort of adult IgAV patients. Additionally, soluble form of haptoglobin scavenger receptor CD163 was measured in IgAV patient serum. Methods: We re-analyzed RNA sequencing data from leukocytes and skin biopsies of treatment-naïve adult IgAV patients: (1) IgAV nephritis (n = 3), (2) skin-limited IgAV (n = 3), and healthy controls (n = 3). Haptoglobin serum level was measured in 178, and haptoglobin genotyping was performed in 91 treatment-naïve adult IgAV patients. Serum sCD163 was measured in 60 IgAV patients and 22 HC. Results: Transcriptomic data of leukocytes and skin of IgAV nephritis patients identified haptoglobin as a hub gene, based on protein-protein interaction network. Haptoglobin serum level was elevated in IgAV patients with nephritis or gastrointestinal involvement compared to other IgAV patients. Patients who relapsed during follow-up had decreased haptoglobin serum level at disease presentation compared to non-relapsing patients. Haptoglobin genotyping did not show differences between genotype groups regarding clinical presentation and laboratory parameters. Serum sCD163 was significantly higher in IgAV nephritis patients compared to HC. Conclusion: We identified haptoglobin as a novel marker of visceral involvement and relapse in adult IgAV, while sCD163 is linked to renal involvement. Further studies will confirm the clinical utility of haptoglobin as biomarker in IgAV. Key Points • Haptoglobin expression is upregulated in leukocytes and skin of adult IgAV with renal involvement. • Haptoglobin serum level is elevated in IgAV patients with visceral involvement. • Patients with IgAV relapse have lower haptoglobin at disease presentation.
Keywords: hepatoglobin, IgA vasculitis, transcription data, biomarker
Published in DiRROS: 01.12.2025; Views: 130; Downloads: 56
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227. The new occurrence of antiphospholipid syndrome in severe COVID-19 cases with pneumonia and vascular thrombosis could explain the post-COVID syndromeMirjana Zlatković Švenda, Melanija Rašić, Milica Ovuka, Slavica Pavlov Dolijanović, Marija Atanasković Popović, Manca Ogrič, Polona Žigon, Snežna Sodin-Šemrl, Marija Zdravković, Goran Radunović, 2025, original scientific article Abstract: Introduction: The classification of antiphospholipid syndrome (APS) comprises clinical criteria (vascular thrombosis or obstetric complications throughout life) and laboratory criteria (antiphospholipid antibodies (aPLs) positivity, confirmed at least twice at 12-week interval). Methods: In 100 patients admitted to the hospital with COVID-19 pneumonia, thrombosis and pregnancy complications were recorded during the hospital stay and in personal medical history. They were tested for nine types of aPLs at four time points (admission, deterioration, discharge, and 3-month follow-up): anticardiolipin (aCL), anti-β2-glycoproteinI (anti-β2GPI), and antiphosphatidylserine/prothrombin (aPS/PT) isotypes IgM/IgG/IgA. Results: During hospitalization, aPLs were detected at least once in 51% of patients. All 7% of deceased patients tested negative for aPLs upon admission, and only one patient became aCL IgG positive as his condition worsened. In 83.3% of patients, intrahospital thrombosis was not related to aPLs. One patient with pulmonary artery and cerebral artery thrombosis was given an APS diagnosis (triple aPLs positivity on admission, double on follow-up). Personal anamnesis (PA) for thromboembolism was verified in 10 patients, all of whom tested negative for aPLs at admission; however, transition to aPLs positivity at discharge (as the disease subsided) was seen in 60% of patients: three of six with arterial thrombosis (at follow-up, two did not appear, and one was negativized) and three of four with deep vein thrombosis (one was confirmed at follow-up and diagnosed with APS, one was negativized, and one did not appear). At admission, the majority of the aPLs were of the aCL IgG class (58.8%). Unexpectedly, as the COVID-19 disease decreased, anti-β2GPI IgG antibodies (linked with thromboses) became newly positive at discharge (14.9%), as confirmed at follow-up (20.8%). Conclusion: The incidence of APS in our cohort was 2.0%, whereas in the general population, it ranges from 0.001% to 0.002%. The incidence might have increased even more if the four aPLs-positive patients with intrahospital thrombosis/history of thrombosis had attended follow-up. Recommendation: All patients with severe COVID-19 or post-COVID syndrome should be evaluated for current/previous thrombosis and tested for aPLs at least twice: at admission to the hospital and at discharge, then retested 3 months later in positive cases in order to be given the appropriate therapy.
Keywords: COVID-19, SARS-CoV2, anti-phosphatidylserine-prothrombin (aPS/PT) antibodies, anti-β2-glycoprotein I (anti-β2GPI) antibodies, anticardiolipin (aCL) antibodies, antiphospholipid antibodies (aPLs), antiphospholipid syndrome, immunology, post-COVID syndrome, vascular thrombosis
Published in DiRROS: 01.12.2025; Views: 146; Downloads: 67
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228. Global Impacts Dataset of Invasive Alien Species (GIDIAS)Sven Bacher, Ellen Ryan-Colton, Mario Coiro, Phillip Cassey, Bella S. Galil, Martin A. Nuñez, Michael Ansong, Katharina Dehnen-Schmutz, Georgi Fayvush, Romina D. Fernandez, Maarten De Groot, 2025, complete scientific database of research data Abstract: We present the Global Impacts Dataset of Invasive Alien Species (GIDIAS), a global dataset of 22865 records including impacts of invasive alien species on nature, nature’s contributions to people, and good quality of life. Records include positive and negative impacts, neutral impacts (studies were carried out, but no impacts were documented), non-directional impacts (i.e., change without detriments or benefits for native species or people), and finally, some records of alien species where no studies were found that assessed their impacts (indicating data gaps). Records cover 3353 invasive alien species from all major taxa (plants, vertebrates, invertebrates, microorganisms) and all continents and realms (terrestrial, freshwater, marine). The data were compiled to serve as robust evidence for chapter 4 “Impacts of invasive alien species on nature, nature's contributions to people, and good quality of life” of the global assessment report on invasive alien species by the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES; available on Zenodo at https://doi.org/10.5281/zenodo.7430731). The dataset is provided in a machine-readable CSV file (file name GIDIAS_20250417_machine_read.csv), with special language characters retained where used (UTF-8 format). The dataset is also provided in Excel format (file name GIDIAS_20250417_Excel.xlsx). Metadata is provided in Excel format, including descriptors for each variable (file name GIDIAS_metadata_20250417.xlsx). Additional explanations for GIDIAS is stored in Microsoft Word format (docx) and contains (1) a short description of the principles of Environmental and Socio-Economic Impact Classification for Alien Taxa (EICAT, SEICAT), (2) a description of the variables included in the Global Impacts Dataset of Invasive Alien Species GIDIAS, and (3) a compilation of the search strategies and datasets included in the Global Impact Dataset of Invasive Alien Species (GIDIAS).
Keywords: invasive alien species, research data
Published in DiRROS: 01.12.2025; Views: 148; Downloads: 61
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229. Reliability of spino-pelvic and sagittal balance parameters assessed during walking in patients with back painArmand Dominik Škapin, Janez Vodičar, Nina Verdel, Matej Supej, Miha Vodičar, 2025, original scientific article Keywords: sport, degenerative spine disease, sagittal balance, gait analysis, synamic assessment, motion capture
Published in DiRROS: 01.12.2025; Views: 129; Downloads: 63
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230. The Prevalence of bacterial vaginosis in pregnant women in Slovenia, determined via microscopy and semi-quantitative relative culture, and its association with adverse pregnancy outcomesMaja Starc, Miha Lučovnik, Petra Eržen Vrlič, Samo Jeverica, 2025, original scientific article Abstract: Bacterial vaginosis (BV) is associated with various adverse pregnancy outcomes. It is usually diagnosed via microscopy. Semi-quantitative relative culture (SRC) was investigated as a complementary diagnostic method to determine the prevalence of BV and its association with preterm birth and preterm, premature rupture of membranes (PPROM) in pregnant women in Slovenia. We examined 3437 consecutive vaginal swabs from pregnant women during the five-year period and were able to link the results to 2531 pregnancy outcomes. The isolates were identified using MALDI-TOF, and the results were assessed by the relative amounts of Gardnerella vaginalis and lactobacilli according to two stringency criteria. The prevalence of BV was 6.5% via microscopy and was higher for SRC, 9.9% or 11.1%, depending on the stringency criteria. The association with adverse pregnancy outcomes was better when SRC was used, resulting in adjusted odds ratios of 1.76 (1.30 to 2.37) and 1.97 (1.38 to 2.82) for preterm birth and PPROM, respectively, with more stringent interpretation. Microscopically detected BV was not associated with either outcome. The clinical validity of SRC was demonstrated by its better correlation with adverse pregnancy outcomes in a large cohort of pregnant women. SRC with MALDI-TOF identification is a promising advancement of vaginal culture.
Keywords: bacterial vaginosis, culture, microscopy, pregnancy, preterm birth, preterm premature rupture of membranes, Slovenia
Published in DiRROS: 01.12.2025; Views: 108; Downloads: 50
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