421. Ticagrelor is associated with increased rosuvastatin blood concentrations in patients who have had a myocardial infarctionTjaša Dermota, Borut Jug, Jurij Trontelj, Mojca Božič Mijovski, 2025, original scientific article Abstract: Aims: The primary objective of this study was to determine whether concomitant therapy with ticagrelor and rosuvastatin affects rosuvastatin plasma concentrations in patients receiving rosuvastatin 40 mg/day after myocardial infarction. Methods: We included 93 patients who had experienced a myocardial infarction and were receiving high-dose rosuvastatin 40 mg/day and a P2Y12 receptor antagonist, either ticagrelor, prasugrel or clopidogrel. We used liquid chromatography with tandem mass spectrometry to measure rosuvastatin plasma concentrations after liquid–liquid extraction. Results: Rosuvastatin plasma concentrations (9.7 ng/mL) were approximately twice as high in patients receiving ticagrelor therapy as in those receiving prasugrel (5.1 ng/mL, p<0.001) or clopidogrel (5.0 ng/mL, p=0.009), and ticagrelor was an independent factor influencing rosuvastatin concentrations. In addition, creatinine levels were associated with increased rosuvastatin concentrations (p=0.039). Conclusion: Our results suggest an important pharmacokinetic interaction between ticagrelor and rosuvastatin, leading to approximately two-fold higher rosuvastatin plasma concentrations in those receiving concomitant ticagrelor than in those receiving prasugrel or clopidogrel. The association is significant and independent of other potential factors influencing rosuvastatin levels, indicating its potential clinical relevance.
Keywords: clopidogrel, drug interactions, rosuvastatin, pharmacokinetics, ticagrelor, concomitant therapy, pharmacokinetic interaction, myocardial infarction
Published in DiRROS: 24.11.2025; Views: 120; Downloads: 65
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425. Slovenian national food consumption survey in adolescents, adults and elderly : external scientific reportMatej Gregorič, Urška Blaznik, Nataša Delfar, Metka Zaletel, Darja Lavtar, Barbara Koroušić-Seljak, Petra Golja, Katja Zdešar Kotnik, Igor Pravst, Nataša Fidler Mis, Stojan Kostanjevec, Majda Pajnkihar, Tamara Poklar Vatovec, Ada Hočevar-Grom, 2019, final research report Keywords: Slovenia, food consumption survey, dietary intake, adults, adolescents, elderly, EU Menu
Published in DiRROS: 24.11.2025; Views: 113; Downloads: 84
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426. Extracellular vesicle-derived bioactive molecules for corneal and ocular surface regenerationAna Kolenc, Živa Dimnik, Miha Marzidovšek, Petra Schollmayer, Marko Hawlina, Elvira Maličev, Zala Lužnik Marzidovšek, 2025, review article Abstract: Cell-based therapies emerge as potential treatment options for various debilitating diseases. Preclinical research and clinical studies involving cells increased exponentially in the past decade. In addition to cell-based approaches, the use of extracellular vesicles (EVs), which are released by nearly all cell types, emerged as a promising cell-free alternative. Those approaches are also being explored in the field of ophthalmology. Several clinical trials involving EVs are underway to develop potential treatments for advanced ocular surface diseases, including corneal disorders, injuries, and dry eye disease. The cargo carried by EVs has been shown to include a diverse array of functional molecules such as transcription factors, cytokines, growth factors, mRNA, tRNA, rRNA, miRNA, and fragments of dsDNA. While the molecular composition of EVs is already well characterised, the specific activity of these molecules upon delivery to recipient cells remains poorly understood. In this review, we summarise recent studies investigating the bioactive molecules within EVs shown to influence or modulate cellular activity on the ocular surface. Among these, various miRNAs have most commonly been identified as therapeutic agents targeting distinct molecular pathways. The EVs studied were predominantly derived from various mesenchymal stem cells.
Keywords: extracellular vesicles, bioactive molecules, cornea, dry eye disease, miRNA, mesenchymal stem cells, ophthalmology
Published in DiRROS: 24.11.2025; Views: 139; Downloads: 70
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