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1.
Consensus molecular subtypes (CMS) in metastatic colorectal cancer : personalized medicine decision
Martina Reberšek, 2020, review article

Abstract: Colorectal cancer (CRC) is one of the most common types of cancer in the world. Metastatic disease is still incurable in most of these patients, but the survival rate has improved by treatment with novel systemic chemotherapy and targeted therapy in combination with surgery. New knowledge of its complex heterogeneity in terms of genetics, epigenetics, transcriptomics and microenvironment, including prognostic and clinical characteristics, led to its classification into various molecular subtypes of metastatic CRC, called consensus molecular subtypes (CMS). The CMS classification thus enables the medical oncologists to adjust the treatment from case to case. They can determine which type of systemic chemotherapy or targeted therapy is best suited to a specific patient, what dosages are needed and in what order. Conclusions. CMS in metastatic CRC are the new tool to include the knowledge of molecular factors, tumour stroma and signalling pathways for personalized, patient-orientated systemic treatment in precision medicine.
Keywords: metastatic colorectal cancer, heterogeneity, biomarkers, consensus molecular subtype
Published in DiRROS: 12.07.2024; Views: 3; Downloads: 1
.pdf Full text (326,09 KB)

2.
The coastal ichthyofauna of the Mediterranean coral reef : the case of Mljet National Park (Croatia, southern Adriatic Sea)
Lovrenc Lipej, Danijel Ivajnšič, Valentina Pitacco, Borut Mavrič, Domen Trkov, Petar Kružić, 2024, original scientific article

Abstract: The authors studied the structure of the coastal fish assemblage in a temperate coral reef within a marine protected area in order to provide a baseline information on the occurrence and temporal distribution of fish and to highlight the importance of the coral reef to ichthyofauna. The coastal fish assemblage was investigated at two sites in Veliko jezero (Mljet National Park) in the southern Adriatic Sea with a non-destructive SCUBA visual technique in the period from 2013 to 2021. Altogether, 38 fish taxa were recorded on the right bank (coral reef) and 36 species on the left bank. The presence of the coral reef at a depth range between 9 m to 12 m is the main factor differentiating the fish fauna in these two areas, which are otherwise governed by the same environmental factors. At the coral reef a decrease in fish diversity was discovered with a steady regression from 2013 to 2021.
Keywords: fish fauna, spatial heterogeneity, Mediterranean coral reef, Cladocora caespitosa, marine protected area, Veliko jezero
Published in DiRROS: 10.05.2024; Views: 173; Downloads: 248
.pdf Full text (2,18 MB)
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