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282. Principles for the fire performance of external wall systemsAndrea Lucherini, Rauan Adikey, Grunde Jomaas, Jose L. Torero, 2025, published scientific conference contribution Abstract: Recent high-profile fires involving combustible façades have exposed significant gaps in both the understanding and regulation of external wall systems. Modern façade designs frequently employ polymers as insulation and/or laminated composite materials that, while improving energy efficiency, can inadvertently create pathways for vertical fire spread. Thus, there is a need to establish fundamental principles for evaluating the fire spread performance of these systems. Drawing on notable incidents, it is shown how uncontrolled flame spread can defeat compartmentation strategies, compromise occupant egress, and overwhelm firefighting efforts. Extending on previous studies, a performance-based approach to fire spread is proposed, examining four levels of relevance: material properties, product characteristics, assembly configuration, and overall building context. Key factors include combustibility, ventilation effects, and real-world variables (e.g., building characteristics). Case studies of testing methods illustrate both utility and limitations in capturing metrics relevant to façade design. Ultimately, it is advocated that there is an urgent need for rigorous, tailored assessment protocols supported by professional competence, thereby ensuring that complex external wall systems can be designed and managed to balance fire safety with sustainability and safety objectives.
Keywords: fire safety, facades, external wall systems, fire spread
Published in DiRROS: 28.11.2025; Views: 75; Downloads: 40
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285. INFRACOMS appraisal toolkit for NRAs to assess emerging technologies in bridge and pavement managementKevin McPherson, Mogens Saberi, Fengqiao Zhang, Anna Arvidsson, Simon Fjendbo, Darko Kokot, Carl van Geem, Ali Yeganeh, 2025, published scientific conference contribution Abstract: National Road Authorities (NRAs) draw on a wide range of technologies and tools to support robust decisions on asset maintenance. However, in recent years there has been significant progress in the development of sensing technologies for data collection and advanced techniques for data processing. These technologies present an opportunity to improve asset management decisions, but also present a challenge for NRAs, as they seek to realise the benefits. This contribution presents the appraisal methodology for emerging technologies proposed by the INFRACOMS project commissioned by the Conference of European Directors of Roads (CEDR). The methodology provides objective appraisals since technologies are scrutinised against proposed subsequent criteria. Cost factors, potential benefit categories and limitations are identified. Technologies are ranked by key imperatives and scored. Technologies with a good score are evaluated more thoroughly, which may need specialist input and discussions with the technology supplier. It results in a technical score, a benefit/cost assessment and identified steps in a roadmap toward implementation. The NRAs can share their individual appraisals in a database. The second part of the project develops an action plan to guide NRAs in adapting and implementing promising emerging technologies and training sessions on the use of the developed appraisal toolkit.
Keywords: monitoring data, digitalisation, sustainability, sustainability, asset condition data, new technologies
Published in DiRROS: 28.11.2025; Views: 69; Downloads: 44
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289. Integrating genetic insights, technological advancements, screening, and personalized pharmacological interventions in childhood obesityRobert Šket, Barbara Slapnik, Primož Kotnik, Klementina Črepinšek, Barbara Čugalj Kern, Tine Tesovnik, Barbara Jenko Bizjan, Blaž Vrhovšek, Žiga Iztok Remec, Maruša Debeljak, Tadej Battelino, Jernej Kovač, 2025, review article Abstract: Childhood obesity is a significant global health challenge with rising prevalence over the past 50 years, affecting both immediate and long-term health outcomes. The increase in prevalence from 0.7% to 5.6% in girls and 0.9% to 7.8% in boys highlights the urgency of addressing this epidemic. By 2025, it is estimated that 206 million children and adolescents aged 5–19 years will be living with obesity. This review explores the complex interplay of genomics and genetics in pediatric obesity, transitioning from monogenic and polygenic obesity to epigenetics, and incorporating advancements in omics technologies. The evolutionary purpose of adiposity, systemic evaluation of hyperphagia, and the role of various genetic factors are discussed. Technological advancements in genotyping offer new insights and interventions. The integration of genetic screening into clinical practice for early identification and personalized treatment strategies is emphasized.
Keywords: hemophilia, wearable, Florio HAEMO, adherence, patient satisfaction
Published in DiRROS: 27.11.2025; Views: 149; Downloads: 76
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290. Correlation of oxidative stress biomarkers with activity of pediatric idiopathic nephrotic syndromeMatjaž Kopač, Aleš Jerin, Ema Bohinc, Joško Osredkar, 2025, original scientific article Abstract: Background/Objectives: This study investigated the correlation of oxidative stress biomarkers with the activity of idiopathic nephrotic syndrome (INS) in Slovenian children. Methods: In this prospective study, sequential plasma and urine samples from 20 children with INS in different phases of disease activity were taken: at first disease presentation or relapse (before glucocorticoid (GC) treatment), at time of remission achievement, and after discontinuation of GC treatment. This study measured oxidative stress biomarkers, such as 8-hydroxy-2′-deoxyguanosine (8-OHdG), hexanoyl-lysine (HEL) adduct, dityrosine (DiY), and 15-isoprostane F2t, using competitive enzyme-linked immunosorbent assay (ELISA) and assessed oxidative status using the FRAS 5 analytical system, which enables rapid photometric measurement of both oxidative and antioxidant capacity from biological fluids. Two complementary tests were performed: the d-ROMs test (derivatives of reactive oxygen metabolites) and the PAT (plasma antioxidant test). The oxidative stress index (OSI) was calculated as the ratio between them. Results: Concentrations of isoprostanes in urine were statistically significantly lower in patients at first disease presentation or relapse compared to time of remission achievement. Values of PAT test in serum were significantly highest after GC treatment. Values of d-ROMs test in serum were significantly lower at time of remission achievement compared to first disease presentation or relapse. Values of 8-OHdG, HEL, DiY (in plasma and urine), isoprostanes, and OSI in plasma did not statistically significantly differ in various phases of disease activity. Conclusions: Isoprostanes in urine and PAT in serum could serve as potential biomarkers of oxidative stress and disease activity in children with INS.
Keywords: oxidative stress biomarkers, idiopathic nephrotic syndrome, children, oxidative stress index
Published in DiRROS: 27.11.2025; Views: 150; Downloads: 67
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