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3. FAIR foundations of a novel indicator vault for non-communicable diseases in the European Union : feasibility study for effective contextualisation of indicatorsIztok Štotl, Fabrizio Carinci, Stephen Fava, Astrid Lavens, Jana Lepiksone, Massimo Massi Benedetti, Tamara Poljičanin, Scott G. Cunningham, 2025, original scientific article Abstract: Background: Comparing health indicators across the European Union (EU) is a challenging endeavour. A feasibility study was conducted to explore opportunities for improvement through the contextualisation of indicators for major non-communicable diseases (NCDs). We aimed to improve the usability and transparency of indicators in the domain of NCDs by describing the contextual information about the data from which they draw and the related data processes. In particular, we sought to illustrate how semantic linkage could be achieved to facilitate interoperability with other metadata models using FAIR data principles. Finally, we aimed to provide recommendations for the implementation of the proposed metadata model at the EU level. Methods: A number of expert group meetings were held between March 2023 and October 2024 to agree on the approach and related technologies to meet the standard requirements for the meaningful comparison of indicators across countries and regions of Europe in the domain of NCDs. Results: The Semantic Ontology-Labelled Indicator Contextualisation Integrative Taxonomy (SOLICIT) was selected as a suitable generic metadata model for contextualising indicators. In this work, we adapted the SOLICIT generic framework to the diabetes sub-domain and extended its applicability more generally across all NCDs. As a proof of concept, we present an example of how to adapt a diabetes indicator and its related contextualisation within SOLICIT. Conclusion: The accurate contextualisation of NCD indicators can substantially improve their use and comparability across national and regional boundaries. This study delivered a set of seven recommendations for implementation in three different areas: (a) contextualisation of common data elements and indicators (use of contextual information; common schema for semantic linkage), (b) generic contextualisation framework (adoption of the framework; use of SOLICIT), and (c) implementation at EU level (pilot test of the model on federated networks; development of European portals; implementation of a user-friendly interface for SOLICIT). The proposed concepts provide a way of validating indicator values and their comparisons, as well as their provision, including all relevant details, encouraging secondary use and potential integration with additional indicator sets. Further studies are needed to test and refine the proposed model.
Keywords: health indicator framework, non-communicable diseases, indicator contextualisation, FAIR, SOLICIT, EHDS, health indicator, metadata
Published in DiRROS: 18.12.2025; Views: 1; Downloads: 0
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6. Functionality of potato virus Y coat protein in cell-to-cell movement dynamics is defined by its N-terminal regionAnže Vozelj, Tjaša Mahkovec Povalej, Katja Stare, Magda Tušek-Žnidarič, Katarina Bačnik, Valentina Levak, Ion Gutiérrez-Aguirre, Marjetka Podobnik, Kristina Gruden, Anna Coll Rius, Tjaša Lukan, 2025, original scientific article Abstract: Potato virus Y (PVY) is one of the top 10 economically most important plant viruses and responsible for major yield losses. We previously suggested the involvement of the N-terminal region of PVY coat protein (CP) in PVY spread. By constructing different N-terminal deletion mutants of the PVY N605 strain, we here show that deletions of 40 or more amino acid residues from the N-terminal region of the CP resulted in the PVY multiplication limited to primary infected cells in Nicotiana clevelandii plants. Deletion of 26 residues profoundly impaired PVY cell-to-cell movement and prevented systemic PVY spread, while deletions of 19-23 residues allowed delayed systemic PVY spread. Introduced point mutations in the identified region prevent (S21G) or delay (G20P) PVY movement. In summary, this work shows the significance of the CP N-terminus for movement of the PVY.
Keywords: potato virus Y, potato, coat proteins, viral movement, point mutations
Published in DiRROS: 18.12.2025; Views: 4; Downloads: 5
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9. Revealing long-term anthropogenic influence on ▫$PM_{10}$▫ through lead isotope signatures in a post-mining regionTjaša Žerdoner, Judita Burger, Irena Kranjc, Janja Turšič, Tea Zuliani, 2026, original scientific article Abstract: This study investigated long-term anthropogenic contributions to airborne particulate matter (PM10) in the Upper Meža Valley, Slovenia, a region historically affected by ore mining, smelting, and, more recently, secondary Pb production. PM10 samples collected at five locations in the summer and autumn of 2018 and at one location in the spring and summer of 2021 were analysed for elemental composition and Pb isotope ratios to identify and quantify pollution sources. Elevated concentrations of Pb, Zn, Cd, and As were observed across all sites, with minimal temporal variations. Enrichment factor (EF) analysis indicated lower EF values for Zn and As, suggesting a primarily crustal origin. Conversely, higher EF values for Cd and Pb pointed to mixed crustal and anthropogenic sources. The proportion of PM10 samples with high Pb enrichment increased from 9.09 % in 2018 to 20.5 % in 2021, indicating a rising influence of anthropogenic emissions. This study represents the first application of Pb isotope composition and a two-endmember mixing model for detailed source apportionment of PM10 in the region. The Pb isotope ratios of PM10 samples fell between local geogenic background and known anthropogenic sources, with anthropogenic contributions accounting for 55.8 %–69.3 % of total Pb in PM10. These findings have important implications for local environmental management, as they can support targeted mitigation strategies, which are critical for public health protection.
Keywords: lead isotopes, air pollution, airborne particulate matter, source apportionment, potentially toxic elements, post-mining region
Published in DiRROS: 18.12.2025; Views: 3; Downloads: 1
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10. Gradnova belogabrovja na karbonatnih in mešanih kamninahAndrej Rozman, Aleš Poljanec, Valerija Babij, Matija Klopčič, Igor Dakskobler, Lado Kutnar, Andrej Bončina, 2025, original scientific article Keywords: Gozdni rastiščni tipi, Slovenija
Published in DiRROS: 18.12.2025; Views: 3; Downloads: 1
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