61. Establishing a robot-assisted liver surgery program : early experience from University Medical Center LjubljanaMiha Petrič, Živa Nardin, Jan Grosek, Aleš Tomažič, Boštjan Plešnik, Blaž Trotovšek, 2026, original scientific article Abstract: Background and Objectives: Robot-assisted procedures represent a significant advancement in minimally invasive liver resection techniques. Nonetheless, the introduction of a novel surgical technique in a new environment necessitates meticulous planning and a gradual, stepwise approach. This study describes the adoption of a robotic surgical platform for liver resection at a high-volume tertiary care center. Materials and Methods: We retrospectively analyzed data that had been prospectively collected from fifty robot-assisted liver resections. Descriptive statistics, including frequencies, percentages, means/medians, and standard deviations, were employed for description and summary. Results: The median operative duration was 166 min (range: 85–400 min), with an average intraoperative blood loss of 200 mL (range: 50–1000 milliliters). Intraoperative or postoperative blood transfusion was required in 8% of patients. Conversion to open resection was necessary in one patient (2%). The mean duration of hospitalization was 5 days (range: 3–20 days), with a 30-day readmission rate of 6% and no mortality within 90 days. Postoperative complications classified as Clavien-Dindo grade 3 or higher were observed in five patients (10%). The mean tumor size varied according to pathology: 58.5 mm (range: 30–120 mm) in the hepatocellular carcinoma group; 27.4 mm (range: 10–32 mm) in the secondary malignancy group; and 42.6 mm (range: 24–60 mm) in the intrahepatic cholangiocarcinoma group. The median number of lymph nodes harvested during lymphadenectomy (IHHCA/GBCA) was 5.4, ranging from 1 to 11. The R0 resection rate for malignant tumors was 88.2% (of 30/34). Conclusions: This study validates the safe integration of robot-assisted surgery into liver disease treatment, supported by our initial experience. Despite its technical advantages, robotic-assisted liver surgery remains complex and demanding. Structured robotic training within established programs, meticulous patient selection, and a stepwise implementation approach are critical during the early phases to optimize the outcomes.
Keywords: robot-assisted surgery, liver surgery, implementation, minimal invasive liver surgery, structured program
Published in DiRROS: 23.12.2025; Views: 59; Downloads: 30
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63. Absorbed energy modeling of hypoeutectoid steels using linear regression and genetic programming taking into account continuous casting parametersMiha Kovačič, Uroš Župerl, Gašper Gantar, 2025, original scientific article Keywords: absorbed energy, Charpy impact test, V-notch test pieces, casting parameters, modeling, linear regression, genetic programming
Published in DiRROS: 22.12.2025; Views: 69; Downloads: 35
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64. Overview of European practices for management of tyrosinemia type 1 : towards European guidelinesAllysa M. Kuypers, Anibh M. Das, Arianna Maiorana, M. Rebecca Heiner-Fokkema, Francjan J. van Spronsen, 2025, original scientific article Abstract: The introduction of nitisinone (NTBC) and newborn screening for Tyrosinemia type 1 (TT1) enabled preemptive treatment ofpatients, thereby significantly improving outcomes by preventing liver, kidney, and neurological issues. Treatment goals haveshifted from emergency treatment to long-term care. To evaluate the risk of developing complications with aging, due to TT1itself or its treatment, long-term follow-up is essential. In 2014, an overview of TT1 management practices in Europe was pub-lished. Within the Metabolic European Reference Network's subnetwork on amino-and-organic acidurias (MetabERN-AOA),we considered it important to give an update on current TT1 management practices in Europe. An online survey study was per-formed among members of the MetabERN-AOA subnetwork, and participants of a workshop on TT1 at the European MetabolicGroup Meeting of Nutricia. Findings were compared to existing data from the aforementioned publication from 2014 and pre-viously published recommendations. Thirty-two centers (16 European countries) completed the survey. Both consistencies andinconsistencies in TT1 management were seen. Inconsistencies were observed in the frequency and methods of follow-up, dosingof NTBC, and target ranges of biochemical markers. Compared to 2014, key differences included an increased number of patientsdetected by newborn screening, lower NTBC dosing, and a shift from interest in mainly hepatic to hepatic and neurocognitiveoutcomes. These results align with trends seen in TT1 recommendations over the years. In addition to numerous consistencies,many aspects in TT1 management still differ widely across Europe, suggesting the need for uniform guidance in clinical man-agement beyond existing recommendations.
Keywords: tyrosinemia type 1, NTBC, nitisinone, management, guidelines
Published in DiRROS: 22.12.2025; Views: 81; Downloads: 44
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65. Midseptal and anteroseptal accessory pathway ablation in childrenLászló Környei, Matevž Jan, Mohammad Ebrahim, Vjekoslav Radeljić, Mirta Rode, 2024, original scientific article Abstract: Objectives: The goal of this study is to document outcomes of ablation for high-risk accessory pathways in paediatrics using 3D mapping systems with minimal to zero fluoroscopy. Methods: It is a cross-sectional, multicentre study, conducted between 2013 and 2023, and involving four different centres in Hungary, Croatia, Kuwait, and Slovenia. Results: A total of 128 procedures were performed on 111 patients. The cohort included 57.8% anteroseptal (AS) pathways and 42.2% midseptal (MS) pathways. The mean follow-up time was 2.0 ± 2.1 years. Cryoablation was used in 72.7% of the cases, and radiofrequency ablation was used in 27.3%. The EnSite Precision™ Cardiac Mapping System was the predominant system used. The overall acute success rate was 89.1%, with recurrence rates at 17.2% with similar results regardless of the type of energy used. The success rate was not significantly different between AS and MS substrates. The age and weight of the patient had no bearing on the outcomes (median age and weight were 13 years and 52 kg, respectively). The complications rate was at 4.69% and included transient AV block (three patients), hematoma (one patient), right bundle branch block (one patient), and possible permanent complete AV block (one patient). Fluoroscopy was utilized in 18 cases, with a fluoroscopy time mean of 3 min and 45 s. Conclusions: MS and AS AP in paediatric patients can be treated effectively with either RF or cryoablation and with a low dose of radiation using 3D mapping systems, with excellent acute success rates and low complication rates.
Keywords: accessory pathway, electrophysiology, radiation dose, cryoablation, heart block
Published in DiRROS: 22.12.2025; Views: 77; Downloads: 41
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66. Impact of incretin-based therapy on skeletal muscle healthAndrijana Koceva, Andrej Janež, Mojca Jensterle Sever, 2025, review article Abstract: Skeletal muscle is the largest insulin-sensitive tissue in the human body, playing a crucial role in glucose homeostasis, body mobility and overall metabolic health. In obesity and type 2 diabetes (T2D), skeletal muscle undergoes structural, functional, and metabolic alterations, including reduced muscle mass, impaired contractile function, increased myosteatosis, mitochondrial dysfunction, and chronic low-grade inflammation. Incretin-based therapies such as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) or dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) RAs are highly effective treatments for T2D and obesity, producing substantial weight loss. While clinical trials suggest proportional loss of fat and lean mass when using incretin-based therapies, emerging preclinical and translational data indicate potential muscle-specific beneficial effects such as attenuation of atrophy, improved myogenesis, enhanced mitochondrial function and reduced myosteatosis. This review comprehensively summarizes the current preclinical and clinical evidence on the impact of incretin-based therapies on skeletal muscle mass, composition, metabolism, and performance, focusing on mechanistic insights from animal models and translational findings from human studies.
Keywords: obesity, incretin-based treatment, liraglutide
Published in DiRROS: 22.12.2025; Views: 68; Downloads: 33
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67. Intermittent ventricular pre-excitation : clinical features and electrophysiological propertiesAntonio Gianluca Robles, Zefferino Palamà, Francesco Santoro, Martin Rauber, Bor Antolič, Matevž Jan, Andrej Pernat, 2025, original scientific article Abstract: Background: Intermittent ventricular pre‐excitation has long been considered a low‐risk marker for sudden death. Accessory pathways (APs) with high‐risk intermittent antegrade conductive properties may exist, but this still represents a gray area in current guidelines. We evaluated differences in risk characteristics between symptomatic and asymptomatic patients with intermittent pre‐excitation (IPX) and those with persistent pre‐excitation (PPX) in a multicenter international registry. Methods: 392 consecutive patients [IPX: 79 (20.15%); PPX: 313 (79.85%)] underwent electrophysiological (EP) study. Data on arrhythmia inducibility (AVRT/AF), AP antegrade conduction properties (ERP/SPERRI), site, and number were collected. Results: No significant differences were found in demographic characteristics and EP features between PPX and IPX patients, including antegrade conductive properties, prevalence of multiple APs, and AP locations, except for AVRT inducibility which was more frequent in IPX group. Similarly, no differences were detected between symptomatic and asymptomatic IPX patients. Conclusions: Except for AVRT inducibility, our study shows no significant differences in demographic and other electrophysiological features between PPX and IPX patients. Likewise, no differences in demographic and EP features were detected between symptomatic and asymptomatic IPX patients. Therefore, intermittent pre‐excitation is an unreliable noninvasive marker of arrhythmic risk and it warrants an invasive risk assessment via EP study.
Keywords: electrophysiological study, intermittent ventricular pre‐excitation, risk stratification, sudden cardiac death, Wolff - Parkinson - White syndrome
Published in DiRROS: 22.12.2025; Views: 78; Downloads: 41
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68. From rock waste to reactive surfaces: : natural gabbro rocks for solar remediation of gaseous and aqueous contaminantsGregor Žerjav, Muhammad Ashraf Sabri, Samar Al Jitan, Riccardo Tribuzio, Hebah Jarusheh, Albin Pintar, Khalid Al-Ali, Andrea Ceriani, Alessandro Decarlis, Giovanni Palmisano, 2026, original scientific article Published in DiRROS: 22.12.2025; Views: 80; Downloads: 46
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69. Načrt za ravnanje z raziskovalnimi podatkiMarta Sendra, Martina Štampar, Bojana Žegura, 2025, other monographs and other completed works Abstract: Načrt za ravnanje z raziskovalnimi podatki za projekt "Environmental Nanoplastics Liver Impact and Variability in Endogenous Networks" (ENLIVEN).
Keywords: ELIVEN, Danio rerio, inducirane pluripotentne matične celice, človeški jetrni organoid, mikroplastika, nanoplastika, projekti
Published in DiRROS: 22.12.2025; Views: 79; Downloads: 26
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