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1192. Cysteine cathepsins as regulators of the cytotoxicity of NK and T cellsMilica Perišić, Jerica Sabotič, Anahid Jewett, Janko Kos, 2014, review article Abstract: Cysteine cathepsins are lysosomal peptidases involved at different levels in the processes of the innate and adaptive immune responses. Some, such as cathepsins B, L, and H are expressed constitutively in most immune cells. In cells of innate immunity they play a role in cell adhesion and phagocytosis. Other cysteine cathepsins are expressed more specifically. Cathepsin X promotes dendritic cell maturation, adhesion of macrophages, and migration of T cells. Cathepsin S is implicated in major histocompatibility complex class II antigen presentation, whereas cathepsin C, expressed in cytotoxic T lymphocytes and natural killer (NK) cells, is involved in processing pro-granzymes into proteolytically active forms, which trigger cell death in their target cells. The activity of cysteine cathepsins is controlled by endogenous cystatins, cysteine protease inhibitors. Of these, cystatin F is the only cystatin that is localized in endosomal/lysosomal vesicles. After proteolytic removal of its N-terminal peptide, cystatin F becomes a potent inhibitor of cathepsin C with the potential to regulate pro-granzyme processing and cell cytotoxicity. This review is focused on the role of cysteine cathepsins and their inhibitors in the molecular mechanisms leading to the cytotoxic activity of T lymphocytes and NK cells in order to address new possibilities for regulation of their function in pathological processes.
Published in DiRROS: 04.09.2025; Views: 291; Downloads: 215
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1195. Zdravljenje raka prostate : kdaj obsevanjeBorut Kragelj, 2019, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: rak prostate, kirurško zdravljenje, radioterapija, obsevanje
Published in DiRROS: 03.09.2025; Views: 357; Downloads: 94
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1197. Votrient (pazopanib) : spremljevalni vodnik za zdravljenjeBreda Škrbinc, 2013, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: rak ledvic, tarčna zdravila, bolniki, onkološki bolniki, vodniki
Published in DiRROS: 03.09.2025; Views: 295; Downloads: 89
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1198. Temozolomid pri zdravljenju bolnikov z možganskim tumorjem : bolnikov dnevnikUroš Smrdel, Lorna Zadravec-Zaletel, Marija Skoblar Vidmar, Gregor Kos, Ana Lina Vodušek, 2024, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: rak glave, temozolomid, možganski tumorji, bolniki
Published in DiRROS: 03.09.2025; Views: 389; Downloads: 88
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1199. The role of carbon presence on the strontium hexaferrite phase decomposition during pressureless spark plasma sintering (pSPS)Aleksander Učakar, Andraž Kocjan, Blaž Belec, Janez Košir, Tanja Kallio, Marjeta Maček, Bor Arah, Petra Jenuš, 2025, original scientific article Abstract: The phase composition and microstructure of Sr-hexaferrite (SFO) ceramics govern the hard magnetic properties. Here, pressureless spark plasma sintering (pSPS) technique was employed for the rapid consolidation (500°C/min) of SFO in a radiating graphite crucible under vacuum and, thus, reductive conditions. A numerical model depicting the temperature profile within the heating crucible was constructed to understand the temperature evolution within the samples. The combination pSPS sintering environment (graphite heating crucible under vacuum) promoted phase decomposition to Sr-enriched and depleted phases of various morphological variations, leading to reduction of hard magnetic properties. Notably, certain newly formed phases exhibited lower melting points, inducing a shift in the sintering mechanism from solid-state sintering to a partial liquid-phase sintering mechanism.
Keywords: pressureless spark plasma sintering, electronic ceramics, numerical simulations
Published in DiRROS: 03.09.2025; Views: 364; Downloads: 166
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1200. Rethinking the Blue economy : integrating social science for equitable and sustainable outcomesJerneja Penca, Irmak Ertör, Marta Ballesteros, Birgit Pauksztat, Maciej Kowalewski, Dražen Cepić, Sebastian Villasante, Michael Briguglio, Natașa Vaidianu, Cristina Piñeiro-Corbeira, Jose Pascual-Fernández, 2025, published scientific conference contribution abstract Published in DiRROS: 03.09.2025; Views: 253; Downloads: 121
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