1. The outcome of IVF/ICSI cycles in male cancer patients : retrospective analysis of procedures from 2004 to 2018Tanja Burnik Papler, Eda Vrtačnik-Bokal, Sašo Drobnič, Martin Štimpfel, 2021, original scientific article Keywords: assisted reproduction techniques, fertility preservation, infertility, pregnancy, sperm cryopreservation
Published in DiRROS: 22.07.2024; Views: 17; Downloads: 6
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2. Effect of the oral intake of astaxanthin on semen parameters in patients with oligo-astheno-teratozoospermia : a randomized double-blind placebo-controlled trialSenka Imamović-Kumalić, Irma Virant-Klun, Eda Vrtačnik-Bokal, Bojana Pinter, 2021, original scientific article Abstract: Background Higher concentrations of seminal reactive oxygen species may be related to male infertility. Astaxanthin with high antioxidant activity can have an impact on the prevention and treatment of various health conditions, including cancer. However, efficacy studies on astaxanthin in patients with oligospermia with/without astheno- or teratozoospermia (O+-A+-T) have not yet been reported. Our aim was to evaluate the effect of the oral intake of astaxanthin on semen parameters. Patients and methods In a randomized double-blind trial, 80 men with O+-A+-T were allocated to intervention with 16 mg astaxanthin orally daily or placebo. At baseline and after three months basic semen parameters, sperm deoxyribonucleic acid (DNA) fragmentation and mitochondrial membrane potential (MMP) of spermatozoa and serum follicle-stimulating hormone (FSH) value were measured. Results Analysis of the results of 72 patients completing the study (37 in the study group, 35 in the placebo group) did not show any statistically significant change, in the astaxanthin group no improvements in the total number of spermatozoa, concentration of spermatozoa, total motility of spermatozoa, morphology of spermatozoa, DNA fragmentation and mitochondrial membrane potential of spermatozoa or serum FSH were determined. In the placebo group, statistically significant changes in the total number and concentration of spermatozoa were determined. Conclusions The oral intake of astaxanthin did not affect any semen parameters in patients with O+-A+-T.
Keywords: DNA fragmentation, antioxidant, cancer
Published in DiRROS: 17.07.2024; Views: 63; Downloads: 29
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3. Hodgkinov limfom : vodnik za bolnikeBarbara Jezeršek Novaković, Samo Zver, Metka Zajc, Aleksandra Grbič, Andreja Cirila Škufca Smrdel, Eda Vrtačnik-Bokal, Vesna Šalamun, Nina Kovačević, Lorna Zadravec-Zaletel, Matej Pečovnik, 2022, not set Keywords: rak (medicina), krvotvorne matične celice, transplantacija, psihološka pomoč, plodnost, hormonsko nadomestno zdravljenje
Published in DiRROS: 24.07.2023; Views: 523; Downloads: 129
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4. Smernice za celostno obravnavo žensk s predrakavimi spremembami materničnega vratuMarjetka Uršič-Vrščaj, Stelio Rakar, Andrej Možina, Borut Kobal, Iztok Takač, Dušan Deisinger, Andrej Zore, 2017, not set Keywords: ginekologija, onkologija, diagnostika, izvidi, postopki
Published in DiRROS: 23.06.2020; Views: 2024; Downloads: 552
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5. Postopki za odkrivanje in obravnavo žensk s predrakavimi spremembami materničnega vratuMarjetka Uršič-Vrščaj, Stelio Rakar, Andrej Možina, Borut Kobal, Iztok Takač, Dušan Deisinger, Andrej Zore, 2011, dictionary, encyclopaedia, lexicon, manual, atlas, map Published in DiRROS: 10.06.2020; Views: 1968; Downloads: 533
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6. Smernice za celostno obravnavo žensk s predrakavimi spremembami materničnega vratuMarjetka Uršič-Vrščaj, Stelio Rakar, Andrej Možina, Borut Kobal, Iztok Takač, Dušan Deisinger, Andrej Zore, 2011, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: ginekologija, onkologija, diagnostika, izvidi, postopki
Published in DiRROS: 05.06.2020; Views: 2034; Downloads: 568
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7. Hodgkinov limfom : vodnik za bolnikeBarbara Jezeršek Novaković, Samo Zver, Metka Zajc, Aleksandra Grbič, Andreja Cirila Škufca Smrdel, Eda Vrtačnik-Bokal, Vesna Šalamun, Vida Stržinar, Lorna Zadravec-Zaletel, Matej Pečovnik, 2014, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: limfomi, maligni limfomi, simptomi, diagnostika, zdravljenje, kemoterapija, stranski učinki, zdravstveni nasveti
Published in DiRROS: 04.06.2020; Views: 2378; Downloads: 705
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8. Prenovljene Smernice za celostno obravnavo žensk predrakavimi spremembami materničnega vratuMarjetka Uršič-Vrščaj, Stelio Rakar, Andrej Možina, Iztok Takač, Dušan Deisinger, Borut Kobal, Andrej Zore, Tatjana Kodrič, Eda Vrtačnik-Bokal, Vida Stržinar, Maja Primic-Žakelj, 2011, published professional conference contribution Published in DiRROS: 07.04.2020; Views: 2122; Downloads: 623
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10. Razporeditev genotipov človeških virusov papiloma pri bolnicah z rakom materničnega vratu in cervikalno intraepitelijsko neoplazijo tretje stopnje (CIN 3) v SlovenijiNina Jančar, Eda Vrtačnik-Bokal, Mario Poljak, 2011, professional article Abstract: Rak materničnega vratu (RMV) se razvije prek več stopenj predrakavih sprememb in ga je z učinkovitim presejalnim programom mogoče preprečiti oz. odkriti in v zgodnjem stadiju uspešno zdraviti. Spolno prenosljiva okužba z visokotveganimi genotipi človeških virusov papiloma (angl. human papillomavirus, HPV) je nujni dejavnik tveganja za nastanek predrakavih sprememb na materničnem vratu in RMV. Pred uvedbo cepljenja proti HPV smo želeli opredeliti razporeditev genotipov HPV pri bolnicah z RMV in bolnicah s predrakavimi spremembami najvišje stopnje (CIN 3) v Sloveniji. Razporeditev genotipov HPV smo analizirali na 284 vzorcih RMV. HPV dezoksiribonukleinsko kislino (DNK) smo dokazali v 262 od 278 vzorcev RMV (94,2 %). Ugotovili smo, da RMV najpogosteje povzročajo HPV 16, HPV 18 in HPV 33. Razporeditev genotipov HPV smo določili tudi na 261 vzorcih brisov materničnega vratu, odvzetih ženskam s CIN 3. V 253 od 261 vzorcev CIN 3 (96,9 %) smo dokazali prisotnost HPV DNK. V 80,6 % vzorcev smo našli le en visokotvegani genotip, v drugih vzorcih smo našli po več genotipov HPV (2 do 9 genotipov). Pri ženskah s CIN 3 so bili najpogosteje zastopani HPV 16, HPV 31 in HPV 33. Profilaktično cepljenje s trenutno dostopnimi cepivi proti HPV bi lahko preprečilo do 77 % primerov RMV in do 60 % primerov CIN 3 v Sloveniji, ki ju povzročata HPV 16 in HPV 18.
Keywords: onkologija, rak materničnega vratu, HPV
Published in DiRROS: 31.08.2018; Views: 3210; Downloads: 835
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