1. Diagnostic performance of p16/Ki-67 dual immunostaining at different number of positive cells in cervical smears in women referred for colposcopyUršula Salobir Gajšek, Andraž Dovnik, Iztok Takač, Urška Ivanuš, Tine Jerman, Simona Šramek Zatler, Alenka Repše-Fokter, 2021, original scientific article Abstract: . The aim of the study was to evaluate the diagnostic accuracy of p16/Ki-67 dual immunostaining (p16/ Ki-67 DS) in cervical cytology and the number of positive p16/Ki-67 cells to diagnose high grade cervical intraepithelial neoplasia (CIN2+) in colposcopy population. Subjects and methods. We performed an analysis on a subset cohort of 174 women enrolled within a large-scale randomised controlled human papillomavirus (HPV) self-sampling project organised as part of the population-based Cervical Cancer Screening Programme ZORA in Slovenia. This subset cohort of patients was invited to the colposcopy clinic, underwent p16/Ki-67 DS cervical cytology and had the number of p16/Ki-67 positive cells determined. Results. Among analysed women, 42/174 (24.1%) had histologically confirmed CIN2+. The risk for CIN2+ was increasing with the number of positive cells (p < 0.001). The sensitivity of p16/Ki-67 DS for detection of CIN2+ was 88.1%, specificity was 65.2%, positive predictive value was 44.6% and negative predictive value was 94.5%. Conclusions. Dual p16/Ki-67 immunostaining for the detection of CIN2+ has shown high sensitivity and high negative predictive value in our study, which is comparable to available published data. The number of p16/Ki-67 positive cells was significantly associated with the probability of CIN2+ detection. We observed a statistically significant and clinically relevant increase in specificity if the cut-off for a positive test was shifted from one cell to three cells. Keywords: cervical cytology, high-grade dysplasia, p16/Ki-67 immunostaining Published in DiRROS: 22.07.2024; Views: 106; Downloads: 35 Full text (441,03 KB) |
2. Randomised trial of HPV self-sampling among non-attenders in the Slovenian cervical screening programme ZORA : comparing three different screening approachesUrška Ivanuš, Tine Jerman, Alenka Repše-Fokter, Iztok Takač, Veronika Kloboves-Prevodnik, Mateja Marčec, Uršula Salobir Gajšek, Maja Pakiž, Jakob Koren, Simona Hutter-Čelik, Kristina Gornik-Kramberger, Ulrika Klopčič, Rajko Kavalar, Simona Šramek Zatler, Biljana Grčar-Kuzmanov, Mojca Florjančič, Nataša Nolde, Srdjan Novaković, Mario Poljak, Maja Primic-Žakelj, 2018, original scientific article Published in DiRROS: 11.06.2024; Views: 182; Downloads: 113 Full text (460,11 KB) This document has many files! More... |
3. Prikaz primera : adenokarcinom endometrija pri mladi asimptomatski ženskiSuzana Peternelj-Marinšek, Simona Šramek Zatler, Alenka Repše-Fokter, 2014, published professional conference contribution Keywords: maternični vrat, brisi, patologija, endometrijske celice, atipične, adenokarcinom, endometrioidni, debelost Published in DiRROS: 08.04.2020; Views: 2227; Downloads: 610 Full text (2,59 MB) |
4. Prikaz primera : VAIN 2 odkrit pri kolposkopiji zaradi patološkega izvida BMVMarko Mlinarič, Uršula Salobir Gajšek, Simona Šramek Zatler, Alenka Repše-Fokter, 2014, published professional conference contribution Keywords: maternični vrat, brisi, patologija, kolposkopija, vaginalna neoplazija, intraepitelijska, humani papilomavirus Published in DiRROS: 08.04.2020; Views: 2098; Downloads: 650 Full text (2,14 MB) |
5. Potek bolezni pri bolnici s CIN in začetnim karcinomom, ki se ni želela zdravitiUršula Salobir Gajšek, Filip Simoniti, Simona Šramek Zatler, Alenka Repše-Fokter, Rajko Kavalar, Alenka Repše-Fokter, 2013, published professional conference contribution Keywords: maternični vrat, novotvorbe, brisi, odklonitev zdravljenja Published in DiRROS: 07.04.2020; Views: 2019; Downloads: 550 Full text (184,51 KB) |