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Abstract: V raziskavi predstavljamo metodo zaščite lesa pred glivnim razkrojem s precipitacijo netopnih bakrovih soli v lumnih lesnih celic z uporabo dvostopenjske impregnacije s topnim bakrovim sulfatom in fiksativom, natrijevim karbonatom. Fiksacija z natrijevim karbonatom se je izkazala kot učinkovita metoda za zmanjšanje izpiranja bakra iz vzorcev. Naravna kapaciteta zadrževanja bakra v beljavi bora je okoli 2000 ppm, kar smo določili z izpiranjem po metodi SIST EN 84. S fiksacijo smo uspešno zadržali v povprečju več kot 5000 ppm bakra v vzorcih in praktično preprečili izpiranje bakra iz vzorcev, impregniranih z 0,5-odstotno raztopino bakrovega sulfata (0,5 % ustreza koncentraciji bakrovih ionov v raztopini). Kljub zadostni koncentraci- ji se je pokazalo, da precipitirana oblika bakrovega karbonata v lesu ne deluje kot učinkovit fungicid, kar je verjetno posledica izjemno slabe topnosti v vodi, ki znaša < 0,005 g/L v sobnih razmerah. Izgube mase po testu SIST EN 113-1 kažejo na slabo zaščito pred gobo Coniophora puteana, vendar na zadovoljivo zaščito pred gobo Gloeophyllum trabeum.
Keywords: zaščita lesa, bakrovi biocidi, fiksacija bakra, glivni razkroj
Published in DiRROS: 17.12.2025; Views: 10; Downloads: 13
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Abstract: In this study, Resupinatus rouxii Consiglio & Setti was collected from Çanakkale province, Türkiye, and identified using both morphological and molecular data. Macroscopically, the species is characterised by its small size, kidney-shaped pileus, light grey colour, and slightly hairy surface. Microscopic examination confirmed diagnostic features of the genus Resupinatus, and detailed evaluations were made of the basidia, basidiospores, and cystidia. The internal transcribed spacer (ITS) region of nuclear ribosomal DNA was sequenced and used in phylogenetic analyses. The resulting ITS sequence showed more than 99% similarity to the reference sequence of R. rouxii, supporting the morphological identification. This study represents the second scientific report of R. rouxii worldwide and provides the fourth known record of this species, extending its known distribution to Türkiye (Çanakkale province) and contributing valuable data to its biogeography.
Keywords: Resupinatus, fungi, new record, internal transcribed spacer region, molecular phylogeny, Turky
Published in DiRROS: 17.12.2025; Views: 62; Downloads: 14
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Abstract: Angiotensin-converting enzyme inhibitors (ACE-Is) and angiotensin receptor blockers (ARBs) are not recommended during the second and third trimester because of the significant risk of congenital anomalies associated with their use. However, data are scarce, especially regarding their use in the first trimester and about the impact of stopping just before pregnancy. Our study illustrates the profile of the women who used ACE-Is or ARBs during pregnancy and evaluates the impact on perinatal outcomes. The Registry of Pregnancy and Cardiac Disease is a prospective, global registry of pregnancies in women with structural heart disease. Outcomes were compared between women who used ACE-Is or ARBs and those who did not. Multivariable regression analysis was performed to assess the effect of ACE-I or ARB use on the occurrence of congenital anomalies. ACE-Is (n = 35) and/or ARBs (n = 8) were used in 42 (0.7%) of the 5,739 Registry of Pregnancy and Cardiac Disease pregnancies. Women who used ACE-Is or ARBs more often came from a low-or-middle-income country (57% vs 40%, p = 0.021), had chronic hypertension (31% vs 6%, p <0.001), or a left ventricular ejection fraction <40% (33% vs 4%, p <0.001). In the multivariable analysis, ACE-I use during the first trimester was associated with an increased risk of congenital anomaly (odds ratio 3.2, 95% confidence interval 1.0 to 9.6). Therefore, ACE-Is should be avoided during pregnancy, also in the first trimester, because of a higher risk of congenital anomalies. However, there is no need to stop long before pregnancy. Preconception counseling is crucial to discuss the potential risks of these medications, to evaluate the clinical condition and, if possible, to change or stop the medication.
Keywords: ACE inhibitor, angiotensin receptor blocker, preconception, pregnancy
Published in DiRROS: 16.12.2025; Views: 37; Downloads: 19
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Abstract: In this work, we fabricate a facile de novo synthesis route to prepare bio-functionalized carbon nitride-reduced graphene oxide with chitosan (Chi) nanocomposite (C3N4/RGO/Chi). The nitrogen-rich C3N4 has been synthesized through facile and low-cost thermal oxidation and offers a metal-free and highly active surface for synergistic modification with RGO and Chi. Moreover, the synergistically incorporated C3N4/RGO and biopolymer improve the electrocatalytic activity, provide surface functionalities, and enhance electroconductivity for immunosensing applications. Consequently, the bio-functionalized C3N4/RGO nanocomposite provides a suitable substrate for the immobilization of SARS-CoV-2 RBD spike protein. The immunosensor detects SARS-CoV-2 antibodies in a wide detection range from 10 zg mL−1 (10 × 10−21 g mL−1) to 100 ng mL−1 with an ultra-low detection limit (LOD) of 3.31 zg mL−1. The validation of the immunosensor was also carried out on spiked serum samples, which show a linear detection range of 100 ag mL−1 to 100 ng mL−1 and a LOD of 1.73 ag mL−1. Nevertheless, the clinical diagnostic application of the immunosensor is validated through the examination of real serum samples from COVID-19 patients. The results suggest that the immunosensor can be efficiently used as a screening platform to distinguish between positive and negative samples with high accuracy. The findings of the work have the potential to translate the immunosensing strategy into next-generation point-of-care testing (POCT) of various infectious diseases.
Keywords: SARS-CoV-2, detection, nanomaterials
Published in DiRROS: 16.12.2025; Views: 40; Downloads: 21
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Abstract: Background: The differential diagnosis of cardiac myxomas (CM), the most common benign primary cardiac tumors, is broad and a thorough diagnostic workup is required to establish accurate diagnosis prior to surgical resection. Transthoracic echocardiography (TTE) is usually the first imaging modality used for diagnosis of suspected CM. In a single tertiary centre study, we sought to determine the accuracy, sensitivity, and specificity of TTE in the diagnosis of CM and to determine echocardiographic characteristics indicative of CM. Patients and methods: We retrospectively analyzed clinical, echocardiographic, and pathohistological findings of 73 patients consecutively admitted for suspected CM. Results: After diagnostic workup, 53 (73%) patients were treated surgically at our institution. Based on preoperative TTE, patients were divided into a CM group (n=45, 85%) and non-myxoma (NM) group. Of the 53 pathohistological specimens obtained during surgery, 39 (73%) were CM. The sensitivity and specificity of preoperative echocardiography were 97% and 50%, respectively. The overall accuracy was 85%. All NM tumors were found in an atypical location and 72% of CM were found in a typical position in the left atrium (p < 0.001). Tumors in NM group were significantly smaller than CM (24.3 ± 13.2 mm vs. 37.9 ± 18.3 mm, p = 0.017). Conclusions: Our study confirms very good accuracy of TTE in the diagnosis of CM. The most important echocardiographic characteristics to differentiate between CM and tumors of different etiology are tumor location and size. Smaller tumors presenting at an atypical location are less likely to be diagnosed as CM, and these require additional imaging modalities for accurate diagnosis.
Keywords: cardiac mass, cardiac myxoma, cardiovascular imaging, echocardiography
Published in DiRROS: 16.12.2025; Views: 35; Downloads: 19
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