1021. Long-term survival of locally advanced stage III non-small cell lung cancer patients treated with chemoradiotherapy and perspectives for the treatment with immunotherapyMartina Vrankar, Karmen Stanič, 2018, original scientific article Abstract: Standard treatment for patients with inoperable locally advanced non-small cell lung cancer (NSCLC) is concurrent chemoradiotherapy (CCRT). Five-year overall survival rates range between 15 and 25%, while long term survival data are rarely reported. Patients and methods A total of 102 patients with stage III NSCLC treated between September 2005 and November 2010 with induction chemotherapy and CCRT were included in this long term survival analysis. All patients were tested for PD-L1 status and expression of PD-L1 was correlated with overall survival (OS), progression free survival (PFS) and toxicities. Results The median OS of all patients was 24.8 months (95% CI 18.7 to 31.0) with 10 year-survival rate of 11.2%. The median OS of patients with PD-L1 expression was 12.1 months (95% CI 0.1 to 26.2), while in patients with negative or unknown PD-L1 status was significantly longer, 25.2 months (95% CI 18.9 to 31.6), p = 0.005. The median PFS of all patients was 16.4 months (95% CI 13.0 to 19.9). PFS of patients with PD-L1 expression was 10.1 months (95% CI 0.1 to 20.4) and in patients with negative or unknown PD-L1 status was 17.9 months (95% CI 14.2 to 21.7), p = 0.003. Conclusions 10-year overall survival of stage III NSCLC patients after CCRT is 11.2%. PFS and OS differ with regard to PD-L1 status and are significantly shorter for patients with PD-L1 expression. New treatment with check-point inhibitors combined with RT therefore seems reasonable strategy to improve these results. Keywords: NSCLC, non-small cell lung cancer, locally advanced, immunotherapy, chemoradiotherapy Published in DiRROS: 10.06.2024; Views: 183; Downloads: 109
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1022. The influence of genetic variability on the risk of developing malignant mesotheliomaAlenka Franko, Nika Kotnik, Katja Goričar, Viljem Kovač, Metoda Dodič-Fikfak, Vita Dolžan, 2018, original scientific article Keywords: malignant mesothelioma, genetic polymorphism, antioxidative enzymes, genetic variability Published in DiRROS: 10.06.2024; Views: 206; Downloads: 75
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1027. First report on the uppermost Permian ostracods from the Masore section (External Dinarides), SloveniaTea Kolar-Jurkovšek, Ewa Olempska, Bogdan Jurkovšek, 2024, original scientific article Abstract: The ostracod assemblages from the Upper Permian and Permian-Triassic transitional strata of the Masore section in the External Dinarides (Slovenia) were studied. Altogether 13 genera and 20 species of the orders Palaeocopida, Platycopida and Podocopida are identified and illustrated. All recovered ostracods belong to shallow marine taxa. The older fauna from the uppermost Permian and the younger fauna from the Permian-Triassic boundary strata are distinguished. The obtained fauna from the Permian Bellerophon Formation corresponds to the “benthonic ostracod Eifelian Mega-assemblage” occupying the shelf sea floors. This study presents the first report of ostracod faunas from the uppermost Permian and Permian-Triassic boundary interval of Slovenia. The recovered ostracod fauna display a distinct faunal change and yield important paleobiogeographic implications as it reveals similarity with stratigraphical equivalent faunas from some other neighboring localities in the western Paleotethys, such as Bulla in Italy, Komirić in Serbia, and the Bükk Mountains in Hungary. Keywords: microfauna, Changhsingian, Permian-Triassic boundary strata, Dinarides Published in DiRROS: 10.06.2024; Views: 178; Downloads: 91
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1028. Quantitative insights on impurities in ice cores at the micro-scale from calibrated LA-ICP-MS imagingPascal Bohleber, Piers Larkman, Nicolas Stoll, David Clases, Raquel Gonzalez de Vega, Martin Šala, Marco Roman, Carlo Barbante, 2024, original scientific article Published in DiRROS: 10.06.2024; Views: 219; Downloads: 184
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1029. Site-specific dataset of mining and metallurgical residues for resource managementCarlo Cormio, Marta Fernández-Alonso, Peter Cleall, Soraya Heuss-Aßbichler, Daniela Guglietta, Danielle Sinnett, Katalin Szabó, Gorazd Žibret, Maria Teresa Carvalho, Ulrich Kral, Tim T. Werner, Bruno Lemiere, 2024, other scientific articles Abstract: This geospatial dataset provides a compilation of findings from an evidence-based review of site-specific resource assessments of mining and metallurgical residues. Information pertaining to location, target material, geological knowledge, extractability, resource classification and stakeholder perspectives was collected from publicly available reports, articles, academic theses, and databases. The dataset includes 44 relevant data attributes from 64 mining and metallurgical sites in 27 countries. Resource classification is available for 38 sites. The dataset can be used by evaluators of recovery projects, authorities that provide permits, as well as by decision makers in support of developing regulatory policies. The dataset facilitates future addition of sites by the research community and can be further used as a starting point to bridge the estimates on recoverable quantities to the United Nations Framework Classification (UNFC). The UNFC is a universally applicable scheme for the sustainable management of all energy, primary and secondary mineral resources. Its use is stimulated by the European Commission and is intended to be adopted by geological surveys to harmonize the data on the availability of primary and secondary raw materials in Europe in future. Keywords: resources, reserves, mining waste, secondary raw materials, tailings, geodatabase, circular economy, resource assessment Published in DiRROS: 10.06.2024; Views: 192; Downloads: 143
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1030. Guanidine modification improves functions of natural RNA-targeting alkaloidsTamaki Endoh, Sagar Satpathi, Yutong Chen, Saki Matsumoto, Tatsuya Ohyama, Peter Podbevšek, Janez Plavec, Kazumitsu Onizuka, Fumi Nagatsugi, Naoki Sugimoto, 2024, original scientific article Published in DiRROS: 10.06.2024; Views: 193; Downloads: 159
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