1181. Cysteine cathepsins as regulators of the cytotoxicity of NK and T cellsMilica Perišić, Jerica Sabotič, Anahid Jewett, Janko Kos, 2014, review article Abstract: Cysteine cathepsins are lysosomal peptidases involved at different levels in the processes of the innate and adaptive immune responses. Some, such as cathepsins B, L, and H are expressed constitutively in most immune cells. In cells of innate immunity they play a role in cell adhesion and phagocytosis. Other cysteine cathepsins are expressed more specifically. Cathepsin X promotes dendritic cell maturation, adhesion of macrophages, and migration of T cells. Cathepsin S is implicated in major histocompatibility complex class II antigen presentation, whereas cathepsin C, expressed in cytotoxic T lymphocytes and natural killer (NK) cells, is involved in processing pro-granzymes into proteolytically active forms, which trigger cell death in their target cells. The activity of cysteine cathepsins is controlled by endogenous cystatins, cysteine protease inhibitors. Of these, cystatin F is the only cystatin that is localized in endosomal/lysosomal vesicles. After proteolytic removal of its N-terminal peptide, cystatin F becomes a potent inhibitor of cathepsin C with the potential to regulate pro-granzyme processing and cell cytotoxicity. This review is focused on the role of cysteine cathepsins and their inhibitors in the molecular mechanisms leading to the cytotoxic activity of T lymphocytes and NK cells in order to address new possibilities for regulation of their function in pathological processes.
Published in DiRROS: 04.09.2025; Views: 284; Downloads: 208
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1184. Zdravljenje raka prostate : kdaj obsevanjeBorut Kragelj, 2019, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: rak prostate, kirurško zdravljenje, radioterapija, obsevanje
Published in DiRROS: 03.09.2025; Views: 357; Downloads: 93
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1186. Votrient (pazopanib) : spremljevalni vodnik za zdravljenjeBreda Škrbinc, 2013, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: rak ledvic, tarčna zdravila, bolniki, onkološki bolniki, vodniki
Published in DiRROS: 03.09.2025; Views: 292; Downloads: 88
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1187. Temozolomid pri zdravljenju bolnikov z možganskim tumorjem : bolnikov dnevnikUroš Smrdel, Lorna Zadravec-Zaletel, Marija Skoblar Vidmar, Gregor Kos, Ana Lina Vodušek, 2024, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: rak glave, temozolomid, možganski tumorji, bolniki
Published in DiRROS: 03.09.2025; Views: 387; Downloads: 88
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1188. The role of carbon presence on the strontium hexaferrite phase decomposition during pressureless spark plasma sintering (pSPS)Aleksander Učakar, Andraž Kocjan, Blaž Belec, Janez Košir, Tanja Kallio, Marjeta Maček, Bor Arah, Petra Jenuš, 2025, original scientific article Abstract: The phase composition and microstructure of Sr-hexaferrite (SFO) ceramics govern the hard magnetic properties. Here, pressureless spark plasma sintering (pSPS) technique was employed for the rapid consolidation (500°C/min) of SFO in a radiating graphite crucible under vacuum and, thus, reductive conditions. A numerical model depicting the temperature profile within the heating crucible was constructed to understand the temperature evolution within the samples. The combination pSPS sintering environment (graphite heating crucible under vacuum) promoted phase decomposition to Sr-enriched and depleted phases of various morphological variations, leading to reduction of hard magnetic properties. Notably, certain newly formed phases exhibited lower melting points, inducing a shift in the sintering mechanism from solid-state sintering to a partial liquid-phase sintering mechanism.
Keywords: pressureless spark plasma sintering, electronic ceramics, numerical simulations
Published in DiRROS: 03.09.2025; Views: 362; Downloads: 165
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1189. Rethinking the Blue economy : integrating social science for equitable and sustainable outcomesJerneja Penca, Irmak Ertör, Marta Ballesteros, Birgit Pauksztat, Maciej Kowalewski, Dražen Cepić, Sebastian Villasante, Michael Briguglio, Natașa Vaidianu, Cristina Piñeiro-Corbeira, Jose Pascual-Fernández, 2025, published scientific conference contribution abstract Published in DiRROS: 03.09.2025; Views: 246; Downloads: 117
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1190. Non-destructive ultrasonic inspections of small-scale mock-ups provided with advanced tungsten armours for DEMO divertor targetRiccardo De Luca, Emanuele Cacciotti, Marco Cerocchi, Aljaž Iveković, Petra Jenuš, Marius Wirtz, 2025, original scientific article Abstract: Within the framework of the EUROfusion Consortium, the Characterization of armour, heat sinks materials and joints sub-project of the Work Package Material (WP-MAT) has been dedicated to the development of different tungsten (W) monoblock mock-ups equipped with advanced materials for divertor target applications in the EU-DEMO fusion reactor. Assessing the status of the relevant joining interfaces of these mock-ups, not only after fabrication but throughout the whole component lifetime, plays a key role in the qualification process. At the ENEA Special Technologies Laboratory (TES), a number of facilities have been built to perform non-destructive inspections of plasma-facing components for fusion applications by ultrasonic testing (UT). The present work reports on the results of the UT inspections assessing the structural integrity of the relevant joining interfaces of three small-scale mock-ups provided with advanced W armour materials, specifically W-matrix with W2C inclusions consolidated by Spark Plasma Sintering (SPS), K-doped rolled W and K-doped laminated W. The UT examinations are carried out after fabrication and after the high heat flux tests (HHFT) at the neutral beam facility GLADIS. All results confirm the high-quality joining achieved by HIP and HRP. During the HHF tests of mock-ups, after a few hundred HHFT cycles defects are detected at the joining interfaces, due to debonding, delamination and W material cracks mainly affecting the loaded zone. The ultrasonic pulse-echo technique provides not only the size and position of the defects in the plane orthogonal to the ultrasonic beam, but also their depth in the material. During the analysis, the probe is inserted inside the pipe and the mock-up is examined in a cylindrical configuration. The coupling medium (demineralized water) is poured only inside the pipe. The main inspection parameters and the piezoelectric probes are chosen to obtain the maximum resolution in accordance with the thickness and joining interfaces to be analyzed.
Keywords: DEMO, divertor, advanced tungsten, high heat flux test, non-destructive test, ultrasonic examination
Published in DiRROS: 03.09.2025; Views: 282; Downloads: 128
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