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1262. Merging heterogeneous graphitic carbon nitride photocatalysis with cobaloxime catalysis in uphill dehydrogenative synthesis of anilinesSonia Zoltowska, Stefano Mazzanti, Sara Stolfi, Jingsan Xu, Matej Huš, Ana Oberlintner, Matic Pavlin, Paolo Ghigna, Blaž Likozar, Piero Torelli, 2025, original scientific article Published in DiRROS: 20.08.2025; Views: 360; Downloads: 191
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1266. Study on thermal deformation of as-CAST S32101 economical duplex stainless steelMing Zhao, Huaying Li, Xiaogang Wang, Guanzheng Su, Fang Huang, Qi Chen, Yibo Lu, 2025, original scientific article Keywords: economical duplex stainless steel, thermal deformation behavior, microstructure evolution, recrystallization, hotworking map
Published in DiRROS: 20.08.2025; Views: 401; Downloads: 195
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1267. Exploring module interactions in modular CMA-ES across problem classesAna Nikolikj, Tome Eftimov, 2025, original scientific article Abstract: This study presents an in-depth analysis of module importance within the modular CMA-ES (modCMA-ES) algorithm using exploratory data analysis and large-scale benchmarking across the BBOB suite. Rather than introducing new algorithms, our contribution lies in uncovering how individual modules and their interactions influence optimization performance across diverse black-box problem classes. We evaluate 324 modCMA-ES variants across 24 problem classes using functional ANOVA (f-ANOVA) to quantify the variance in performance attributable to individual, pairwise, and triplet module interactions. Results reveal substantial variation in module importance across problem classes and highlight strong alignment between module interaction patterns and high-level landscape features, particularly multi-modality. Further, we demonstrate that configuring only the most important modules — identified via f-ANOVA — achieves performance comparable to or better than the single-best solver, especially in high-dimensional settings. This analysis, conducted at both low (5D) and high (30D) dimensions, offers actionable insights into module interactions within the mod-CMA-ES framework.
Keywords: module importance, empirical study, black-box optimization, benchmarking
Published in DiRROS: 20.08.2025; Views: 404; Downloads: 177
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1268. Dielectric properties of ▫$FeGaInS_4/PVA$▫ composites: influence of filler concentrationsMahammad Baghir Baghirov, Mustafa Muradov, Zeynab Addayeva, Namiq Niftiyev, Faik Mammadov, Goncha Eyvazova, Marjetka Conradi, 2025, original scientific article Keywords: FeInGaS4/PVA composites, dielectric properties, electrical conductivity, semiconductor filler
Published in DiRROS: 20.08.2025; Views: 374; Downloads: 187
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1270. Thiol-reactive or redox-active : revising a repurposing screen led to a new invalidation pipeline and identified a true noncovalent inhibitor against papain-like protease from SARS-CoV-2Maria Kuzikov, Stefano Morasso, Jeanette Reinshagen, Markus Wolf, Vittoria Monaco, Flora Cozzolino, Simona Golič Grdadolnik, Primož Šket, Janez Plavec, Daniela Iaconis, 2025, original scientific article Abstract: The SARS-CoV-2 papain-like protease PLpro has multiple roles in the viral replication cycle, related to both its polypeptide cleavage function and its ability to antagonize the host immune response. Targeting the PLpro function is recognized as a promising mechanism to modulate viral replication, while supporting host immune responses. However, the development of PLpro-specific inhibitors remains challenging. Comprehensive investigations utilizing enzymatic, binding studies, and cellular assays revealed the previously reported inhibitors to act in an unspecific manner. At present, GRL-0617 and its derivatives remain the best-validated compounds with demonstrated antiviral activity in cells and in mouse models. In this study, we refer to the pitfalls of the redox sensitivity of PLpro. Using a screening-based approach to identify inhibitors of PLpro’s proteolytic activity, we made extensive efforts to validate active compounds over a range of conditions and readouts, emphasizing the need for comprehensive orthogonal data when profiling putative PLpro inhibitors. The remaining active compound, CPI-169, was shown to be a noncovalent inhibitor capable of competing with GRL-0617 in NMR-based experiments, suggesting that it occupied a similar binding site and inhibited viral replication in Vero-E6 cells, opening new design opportunities for further development as antiviral agents.
Keywords: SARS-CoV-2, drug repurposing, papain-like protease, redox, STD-NMR, CPI-169, GRL-0617
Published in DiRROS: 20.08.2025; Views: 355; Downloads: 170
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