1691. Analysis of alkali-activated mineral wool-slag binders : evaluating the differences between one-part and two-part variationsElijah Adesanya, Rawia Dabbebi, Christine Rößler, Majda Pavlin, Zhenming Li, Tero Luukkonen, Juho Yliniemi, Mirja Illikainen, 2024, original scientific article Abstract: Two synthesis pathways (one- and two-part) in alkali-activated binders were compared using ground granulated blast furnace slag (GGBFS), mineral wool (MW) activated using dry and liquid alkali activators with similar Na2O/SiO2 modulus. The effect of activator type on reaction kinetics, strength development, setting times, and durability shows that one-part synthesis does not only improve early strength, but also provide better durability properties. While the highest compressive strength (56 MPa, 90 days) was achieved for the one-part mix (DM), the reaction products (presence of Mg–Al layered double hydroxide and C–S–H-like phases) observed for both mortar mixes were similar. The DM mortars showed better resistance to sulfate attack than two-part mix (WM) mortars and sets faster. The results highlight the significance of the one-part pathways in the synthesis of alkali-activated materials. Keywords: recycling, alkali activated material, mineral wool Published in DiRROS: 11.03.2024; Views: 342; Downloads: 270
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1692. Ornate Bairdiidae (Ostracoda) in 3 dimensions : exploring carapace morphology and pore canals of Triebelina van den Bold, 1946, Nodobairdia Kollmann, 1963 and Mirabairdia Kollmann, 1963Marie-Béatrice Forel, Nathalie Poulet-Crovisier, Lidija Korat, Rosalie F. Maddocks, 2024, original scientific article Abstract: Marine ostracods of the family Bairdiidae Sars, 1888 have an evolutionary history starting from the Ordovician with an explosive diversification of ornate forms during the Triassic. Representatives of the family are notoriously homeomorphic, which makes their taxonomy a major challenge of modern ostracodology. Their classification has thus been problematic since the 1970s. Here we present the first CT-scan investigation of recent and fossil ornate Bairdiidae valves in order to characterize and evaluate the taxonomic significance of unexploited characters, such as pores and pore canals. Thanks to 3D tomography, we explore the distribution of pores at the surface and the pathway of pore ca- nals within the valve wall of the recent genus Triebelina van den Bold, 1946 and the Triassic genera Nodobairdia Kollmann, 1963 and Mirabairdia Kollmann, 1963. In Triebelina indopacifica van den Bold, 1946, we describe an unexpected system of double pore canals, so far unknown in ostracods. We confirm that pore systems in Triebelina have largely intramural positions. In the Triassic Bairdiidae (Nodobairdia mammilata Kollmann, 1963 and Mirabairdia pernodosa Kollmann, 1963), we recognize simple unrimmed and massively nodular pores as well as marginal pores. Lateral normal pores of the Triassic specimens appear to be mostly in intra-solum positions. Although still exploratory and at the limits of the tomographic resolution, these observations provide new evidence to reject the formerly proposed synonymy of Triassic genera with Triebelina, which obstructed the establishment of a phylogenetic classification. Keywords: ostracods, ornate Bairdiidae, morphology, normal pore canals, CT-scan, 3D analysis Published in DiRROS: 08.03.2024; Views: 352; Downloads: 267
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1697. Postoperative radiochemotherapy for gastric adenocarcinoma : long term resultsIrena Oblak, Franc Anderluh, Vaneja Velenik, 2009, original scientific article Abstract: Background. To analyze the efficacy of postoperative radiochemotherapy with 5-florouracil (5-FU) and leucovorin (LV) applied in the patients with gastric carcinoma treated in a single institution. Patients and methods. Between 2001 and 2004, 123 patients with resected gastric adenocarcinoma were treated with postoperative concomitant radiochemotherapy with 5-FU and LV. The adjuvant treatment consisted of five cycles of chemotherapy with 5-FU (425mg/m2 IV) andLV (20 mg/m2 IV) and concomitant radiotherapy with the total dose of 45 Gy.Results. The treatment was completed according to the protocol in 82% of patients. The frequency and severity of early toxic effects induced by radiochemotherapy were manageable. Median follow-up time of 56 survivors was 64.5 months (range: 51.7-96.4 months). The 5-year locoregional control (LRC), diseasefree survival (DFS), disease-specific survival (DSS) and overall survival (OS) were 81%, 48.3%, 50.4%, and 48.4%, respectively. The multivariate analysis showed that the tumor involvement of cardia and low intensity of chemotherapy were independent adverse prognostic factors for DSS and OS. More advanced pT-stage and tumors with diffuse growth type according to Lauren were identified as negative independent prognostic factor for OS. They were also on the threshold of statistical significance for DSS. Conclusions. Postoperative radiochemotherapy for gastric carcinoma has acceptable toxicity, and is effective particularly in regard to LRC. High incidence of distant metastases calls for more effective systemic regimens. Published in DiRROS: 08.03.2024; Views: 283; Downloads: 81
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1698. Influence of surgical treatment and radiotherapy of the advanced intraoral cancers on complete blood count, body mass index, liver enzymes and leukocyte CD64 expressionTadej Dovšak, Alojz Ihan, Vojislav Didanovič, Andrej Kansky, Nataša Ihan Hren, 2009, original scientific article Abstract: Background. The aim of our study was to evaluate the influence of the surgery and radiotherapy of the advanced oral squamous cell carcinoma on the complete blood count, body mass index (BMI), acute inflam-matory response, liver enzymes and expression of the CD64 index on leukocytes in the peripheral blood. Patients and method. Venous blood was obtained from 16 patients with advanced oral squamous cell carcinomas treated with radical surgery and external beam radiotherapy. Blood samples were collected prior to surgery (T1), after surgery (T2) and after radiotherapy (T3). Blood samples were analyzed for whole blood count, immunoglobulin G levels, liver enzymes (transaminases (ALT and AST) and gammaglutamyl trasferase (?-GT)), inflammatory response markers (C-reactive protein, erythrocyte sedimentation rate, albumin, white blood count, leukocyte count and CD64 expression on leukocytes). Assessment of nutrition was done by calculating the body mass index.Results. Surgery caused anaemia, trombocytosis, leukocytosis, lymphopenia, rise in acute phase proteins, elevation of CD64 expression on monocytes and neutrophyls, elevation of liver transaminases and lowering of ?-GT, albumin, protein and bilirubin levels. After radiotherapy haemoglobin, leukocytes, C-reactive protein, erythrocyte sedimentation rate, liver transferases, albumin, bilirubin and proteins returned almost to T1 levels, levels of lymphocytes, ?-GT and body mass index lowered. IgG levels remained almost unchanged at T2 and T3. Levels of the CD64 expression on monocytes and neutrophyls also elevated after radiotherapy.Conclusions. Surgery caused a significantly larger acute phase response than radiotherapy, while radiotherapy worsened the already present lymphopenia. Published in DiRROS: 08.03.2024; Views: 366; Downloads: 85
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1699. Increased late urinary toxicity with whole pelvic radiotherapy after prostatectomyBorut Kragelj, 2009, original scientific article Abstract: Background. Radiotherapy aimed at prostatic bed (PBRT) can prevent recurrence or reestablish remission in prostate cancer patients primarily treated with prostatectomy. In selected patients results may be improved with the additional irradiation of pelvic nodes (WPRT). Patients and methods. The objective of the study was to evaluate late toxicity of postoperative radiotherapy in 43 patients - 21/43 treated with WPRT. Dysuria, haematuria, nocturia, continence and obstructive urination problems as well as urgency, continence, frequency, pain and bleeding of defecations were prospectively registered and converted to a modified Radiation Therapy Oncology Group (RTOG)- late effects normal tissue (LENT) scoring system. Median tumour dose (TD) for PBRT was 64.8 (59.4-70.0) Gy and for WPRT 50.4 (48.0-56.0) Gy. Results. More important than the deterioration of intestinal function (worsening for 1 grade in 54% and >= 2 grades in 5% of patients) was the deterioration of urinary function (worsening for 1 grade in 33% and >= 2 grades in 26% of patients). This appeared to be more frequent in patients withWPRT than PBRT (67% vs. 50% of patients) especially in conjunction with WPRT TD > 52 Gy (deterioration in 71% of patients). Conclusions. Although several factors may influence increased urinary toxicity after WPRT, it seems reasonable to lower the urinary bladder dose as it possible with novel radiation techniques. Published in DiRROS: 08.03.2024; Views: 333; Downloads: 80
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1700. Is there any progress in routine management of lung cancer patients? A comparative analysis of an institution in 1996 and 2006Lučka Debevec, Tina Jerič, Viljem Kovač, Marko Bitenc, Mihael Sok, 2009, original scientific article Abstract: Background. The aim of the study was to establish eventual progress in routine management of lung cancer patients over a ten-year period at University Clinic for Respiratory and Allergic Diseases Golnik, Slovenia, comparing the results of analysis of 345 patients, diagnosed in 1996 (with analysis performed in 2002), and 405 patients, diagnosed in 2006 (with analysis performed in 2008).Patients and methods. The patients of both analysed groups were of comparable age and number of patients in stage I and II, but there were relatively more females, patients with better performance status, more precise clinical staging and tumour histology in the 2006 group. The parameters used for assessing the progress of management were as follows: time period from admittance to diagnosis and to surgery; precision of staging; accordance of clinical and pathological staging in resected patients; percentage of exploratory thoracotomy; and use of new treatment modalities. The proportion of patients in selected/actual primary treatment modality and survival rate could also be used for assessing the progress. Results. Althoughunessential longer time from admittance to microscopic confirmed diagnosis increased from a mean 7.4 to 8.6 days in 2006 progress was established by the following: more precise clinical staging (stage I and II also A and B stage, TNM staging also in small-cell lung cancer patients); improved accordance with clinical and pathological staging in resected patients (46% against 58%); decreased percentage of exploratory thoracotomy (13% against 4%); increased use of multimodality therapy as primary treatment modality (radiotherapy/chemotherapy, neoadjuvant chemotherapy); newly performed radio frequency tumour ablation. The proportion in selected/actual surgery increased from 76% to 93% and median survival rate of all patients from 6.2 to 10.6 months. (Abstract truncated at 2000 characters) Published in DiRROS: 08.03.2024; Views: 343; Downloads: 79
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