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2. Advances in the management of craniopharyngioma in children and adultsMojca Jensterle Sever, Sončka Jazbinšek, Roman Bošnjak, Mara Popović, Lorna Zadravec-Zaletel, Tina Vipotnik-Vesnaver, Barbara Faganel Kotnik, Primož Kotnik, 2019, review article Abstract: Childhood and adult-onset craniopharyngioma is a rare embryogenic tumor of the sellar, suprasellar, and parasellar region. Survival rates are high; however, tumor location and treatment sequalae including endocrine deficits, visual impairment, metabolic complications, cognitive and psychosocial deficits can significantly impair patient%s quality of life. There is considerable controversy regarding the optimal management of craniopharyngiomas. Subtotal resection of the tumor followed by targeted irradiation to avoid further hypothalamic damage is currently indicated. Novel insights in the tumor%s molecular pathology present the possibility for targeted therapy possibly decreasing the rate and severity of treatment-associated morbidity. Conclusions. Craniopharyngioma should be seen as a chronic disease. To achieve optimal outcomes a multidisciplinary team of specialized neurosurgeons, neuro-radiologists, neuro-oncologists, pathologists and endocrinologists should be involved in the diagnosis, planning of the surgery, irradiation and long-term follow-up.
Keywords: craniopharyngioma, hypopituitarism, metabolic syndrome
Published in DiRROS: 09.07.2024; Views: 158; Downloads: 77
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3. Diagnostic accuracy of haemophilia early arthropathy detection with ultrasound (HEAD-US) : a comparative magnetic resonance imaging (MRI) studyDomen Plut, Barbara Faganel Kotnik, Irena Preložnik Zupan, Damjana Ključevšek, Gaj Vidmar, Žiga Snoj, Carlo Martinoli, Vladka Salapura, 2019, original scientific article Keywords: haemophilia, haemophilic arthropathy, magnetic resonance imaging
Published in DiRROS: 09.07.2024; Views: 142; Downloads: 68
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4. Association between SLC19A1 gene polymorphism and high dose methotrexate toxicity in childhood acute lymphoblastic leukaemia and non Hodgkin malignant lymphoma : introducing a haplotype based approachBarbara Faganel Kotnik, Janez Jazbec, Petra Bohanec Grabar, Christina Rodriguez-Antona, Vita Dolžan, 2017, original scientific article Keywords: acute lymphoblastic leukaemia, genetic polymorphism, haplotype, methotrexate
Published in DiRROS: 31.05.2024; Views: 205; Downloads: 163
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5. The influence of folate pathway polymorphisms on high-dose methotrexaterelated toxicity and survival in children with non-Hodgkin malignant lymphomaNina Erčulj, Barbara Faganel Kotnik, Maruša Debeljak, Janez Jazbec, Vita Dolžan, 2014, original scientific article Abstract: Background. We evaluated the influence of folate pathway polymorphisms on high-dose methotrexate (HD-MTX) related toxicity in paediatric patients with T-cell non-Hodgkin lymphoma (NHL). Patients and methods. In total, 30 NHL patients were genotyped for selected folate pathway polymorphisms. Results. Carriers of at least one MTHFR 677T allele had significantly higher MTX area under the time-concentration curve levels at third MTX cycle (P = 0.003). These patients were also at higher odds of leucopoenia (P = 0.006) or thrombocytopenia (P = 0.041) and had higher number of different HD-MTX-related toxicity (P = 0.035) compared to patients with wild-type genotype. Conclusions. Our results suggest an important role of MTHFR 677C>T polymorphism in the development of HD-MTXrelated toxicity in children with NHL.
Keywords: childhood, non-Hodgkin lymphoma, polymorphism
Published in DiRROS: 16.04.2024; Views: 252; Downloads: 163
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6. Predlog priporočil za celostno rehabilitacijo otrok z možganskim tumorjemLidija Kitanovski, Katja Groleger Sršen, Nataša Kos, Barbara Faganel Kotnik, Primož Kotnik, Ivana Kreft, Lorna Zadravec-Zaletel, Saba Battelino, 2019, published professional conference contribution (invited lecture) Keywords: pediatrija, onkologija, možganski tumor, otroška onkologija
Published in DiRROS: 18.09.2019; Views: 2492; Downloads: 668
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