1. Artificial intelligence (AI) and strategic planning process within VUCA environments : a ǂresearch agenda and guidelinesRoberto Biloslavo, David A. Edgar, Erhan Aydin, Çağri Bulut, 2024, original scientific article Abstract: Purpose – This study demonstrates how artificial intelligence (AI) shapes the strategic planning process in
volatile, uncertain, complex and ambiguous (VUCA) business environments.Having adopted various domains
of the Cynefin framework, the research explores AI’s transformative potential and provide insights regarding
how organisations can harness AI-driven solutions for strategic planning.
Design/methodology/approach –This conceptual papertheorises the role of AIin strategic planning process
in a VUCA world by integrating extant knowledge across multiple literature streams. The “model paper”
approach was adopted to provide a theoretical framework predicting relationships among considered concepts.
Findings – The paper highlights potential application of the Cynefin framework to manage complexities in
strategic decision-making process, the transformative impact of AI at different stages of strategic planning,
the required strategic planning characteristics within VUCA to be supported by AI and the attendant
challenges posed by AI integration in the uncertain business landscape.
Originality/value –This study pioneers a theoretical exploration of AI’s role in strategic planning within the
VUCA business landscape, guided by the Cynefin framework. Thus, it enriches scholarly discourse and
expands knowledge frontiers.
Keywords: artificial intelligence, strategic planning, VUCA
Published in DiRROS: 12.07.2024; Views: 12; Downloads: 4
 Full text (13,45 MB) |
2. Initial presenting manifestations in 16,486 patients with inborn errors of immunity include infections and noninfectious manifestationsJulian Thalhammer, Gerhard Kindle, Alexandra Nieters, Stephan Rusch, Mikko R. J. Seppänen, Alain Fischer, Bodo Grimbacher, David Edgar, Matthew Buckland, Nizar Mahlaoui, 2021, original scientific article Abstract: Background. Inborn errors of immunity (IEI) are rare diseases, which makes diagnosis a challenge. A better description of the initial presenting manifestations should improve awareness and avoid diagnostic delay. Although increased infection susceptibility is a well-known initial IEI manifestation, less is known about the frequency of other presenting manifestations. Objective. We sought to analyze age-related initial presenting manifestations of IEI including different IEI disease cohorts. Methods. We analyzed data on 16,486 patients of the European Society for Immunodeficiencies Registry. Patients with autoinflammatory diseases were excluded because of the limited number registered. Results. Overall, 68% of patients initially presented with infections only, 9% with immune dysregulation only, and 9% with a combination of both. Syndromic features were the presenting feature in 12%, 4% had laboratory abnormalities only, 1.5% were diagnosed because of family history only, and 0.8% presented with malignancy. Two-third of patients with IEI presented before the age of 6 years, but a quarter of patients developed initial symptoms only as adults. Immune dysregulation was most frequently recognized as an initial IEI manifestation between age 6 and 25 years, with male predominance until age 10 years, shifting to female predominance after age 40 years. Infections were most prevalent as a first manifestation in patients presenting after age 30 years. Conclusions. An exclusive focus on infection-centered warning signs would have missed around 25% of patients with IEI who initially present with other manifestations.
Keywords: immunity, autoimmune diseases, inflammation, signs and symptoms, registries, inborn error of immunity, primary immunodeficiency, immune dysregulation
Published in DiRROS: 28.05.2021; Views: 1087; Downloads: 273
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