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3. Complex biophysical and computational analyses of G-quadruplex ligands : the porphyrin stacks backGiuseppe Satta, Marko Trajkovski, Alessio Cantara, Monica Mura, Claudia Meloni, Giulia Olla, Michaela Dobrovolna, Luisa Pisano, Silvia Gaspa, Andrea Salis, Lidia De Luca, Janez Plavec, 2024, original scientific article Published in DiRROS: 14.01.2025; Views: 18; Downloads: 18
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4. Endangered plants important for selected European countriesDalibor Ballian, 2024, dictionary, encyclopaedia, lexicon, manual, atlas, map Keywords: pomen, ogroženost, geografska razširjenost, albumi, elektronske knjige
Published in DiRROS: 14.01.2025; Views: 9; Downloads: 2
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7. Predicting the effective char depth in timber elements exposed to natural fires, including the cooling phaseAndrea Lucherini, Daniela Šejnová Pitelková, Vladimír Mózer, 2023, published scientific conference contribution Abstract: This paper presents a numerical study on the effect of the heating and cooling phases on the reduction of the effective cross-section of timber elements, in particular on the evolution of the char depth (300°C isotherm) and zero- strength layer. An advanced calculation method based a finite-difference heat transfer model is compared to the simplified approach suggested by Eurocode 5. For the heating phase, defined as the standard fire curve (ISO 834), the simplified Eurocode 5 method generally provides more conservative char depths, while the zero-strength layer is under-predicted. Nevertheless, the values of effective char depth are comparable. Including the cooling phase evidences that, during this phase, the heat wave penetration leads to a significant increase in the char depth and zero-strength layer. Particularly, this increase directly depends on the fire cooling rate: a slower cooling phase further reduces the effective cross-section of timber members. As a result, this research highlights how the heat wave penetration during the fire cooling phase can significantly reduce the load-bearing capacity of timber elements.
Keywords: timber structures, fire safety, heat transfer, charring, zero-strength layer, cooling
Published in DiRROS: 14.01.2025; Views: 11; Downloads: 7
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8. Cortico-muscular phase connectivity during an isometric knee extension task in people with early Parkinson’s diseaseNina Omejc, Tomislav Stankovski, Manca Peskar, Miloš Kalc, Paolo Manganotti, Klaus Gramann, Sašo Džeroski, Uroš Marušič, 2025, original scientific article Abstract: — Introduction: Parkinson’s disease (PD) is characterized by enhanced beta-band activity (13–30 Hz) in the motor control regions. Simultaneously, corticomuscular (CM) connectivity in the beta-band during isometric contractions tends to decline with age, in various diseases, and under dual-task conditions. Objective: This study aimed to characterize electroencephalograph (EEG) and electromyograph (EMG) power spectra during a motor task, assess CM phase connectivity, and explore how these measures are modulated by an additional cognitive task. Specifically, we focused on the beta-band to explore the relationship between heightened beta amplitude and reduced beta CM connectivity. Methodology: Early-stage people with PD and age-matched controls performed an isometric knee extension task, a cognitive task, and a combined dual task, while EEG (128ch) and EMG (2x32ch) were recorded. CM phase connectivity was assessed through phase coherence and a phase dynamics model. Results: The EEG power spectrum revealed no cohort differences in the beta-band. EMG also showed no differences up to 80 Hz. However, the combined EEG-EMG analysis uncovered reduced beta phase coherence in people with early PD during the motor task. CM phase coherence exhibited distinct scalp topography and frequency ranges compared to the EEG power spectrum, suggesting different mechanisms for pathological beta increase and CM connectivity. Additionally, phase dynamics modelling indicated stronger directional coupling from the cortex to the active muscle and less prominent phase coupling across people with PD. Despite high inter-individual variability, these metrics may prove useful for personalized assessments, particularly in people with heightened CM connectivity.
Keywords: electroencephalography, brain modeling, electromiography, coherence, motors, diseases, couplings, electrodes, oscillators, protocols
Published in DiRROS: 13.01.2025; Views: 39; Downloads: 13
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9. Exposure to specific fungal lectins during adhesionimpairs biofilm formation of Listeria on polystyreneNikolaja Janež, Márta Ladányi, Meta Sterniša, Blaž Jug, Tanja Zupan, Tjaša Peternel, Aleksandar Sebastijanović, Milica Perišić, Katarina Karničar, Ajda Taler-Verčič, Dušan Turk, Anja Klančnik, Janez Štrancar, Jerica Sabotič, 2024, original scientific article Abstract: Listeria monocytogenes is a pathogenic bacterium that can form biofilms in food processing plants, allowing the bacteria to survive despite the control measures applied. As the surface of the bacteria is covered with versatile polysaccharides and proteins, these influence the interactions of the bacterium with any surface. The unique properties and high stability of fungal proteins make them good candidates for the control of bacteria by targeting surface structures. We screened a group of fungal lectins and protease inhibitors from different fungal species, protein folds and known targets for their antibacterial and antibiofilm activity against model strains of Listeria innocua and Listeria monocytogenes. Several of them significantly decreased the viability of biofilm bacteria, but had no effect on bacterial growth parameters at 37°C and thus had no antibacterial activity. Fungal lectins significantly impaired biofilm development even at room temperature, which was attributed to exposure to lectins during adhesion. The tested fungal proteins also reduced biofilm development on biological model surfaces. The observed antibiofilm activity of fungal proteins suggests that they have the potential to modulate interactions between bacteria and/or between bacteria and surfaces, which could be used in the future to reduce surface contamination by Listeria.
Keywords: Listeria monocytogenes, biofilm
Published in DiRROS: 13.01.2025; Views: 47; Downloads: 15
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