1. Awake craniotomy for operative treatment of brain gliomas - experience from University Medical Centre LjubljanaTilen Žele, Tomaž Velnar, Blaž Koritnik, Roman Bošnjak, Jasmina Markovič Božič, 2023, original scientific article Abstract: Background. Awake craniotomy is a neurosurgical technique that allows neurophysiological testing with patient cooperation during the resection of brain tumour in regional anaesthesia. This allows identification of vital functional (i.e. eloquent) brain areas during surgery and avoidance of their injury. The aim of the study was to present clinical experience with awake craniotomy for the treatment of gliomas at the University Medical Centre Ljubljana from 2015 to 2019.Patients and methods. Awake craniotomy was considered in patients with a gliomas near or within the language brain areas, in all cases of insular lesions and selected patients with lesions near or within primary motor brain cortex. Each patient was assessed before and after surgery.Results. During the 5-year period, 24 awake craniotomies were performed (18 male and 6 female patients; average age 41). The patient’s cooperation, discomfort and perceived pain assessed during the awake craniotomy were in majority of the cases excellent, slight, and moderate, respectively. After surgery, mild neurological worsening was observed in 13% (3/24) of patients. Gross total resection, in cases of malignant gliomas, was feasible in 60% (6/10) and in cases of low-grade gliomas in 29% (4/14). The surgery did not have important negative impact on functional status or quality of life as assessed by Karnofsky score and Short-Form 36 health survey, respectively (p > 0.05). Conclusions. The results suggest that awake craniotomy for treatment of gliomas is feasible and safe neurosurgical technique. The proper selection of patients, preoperative preparation with planning, and cooperation of medical team members are necessary for best treatment outcome.
Keywords: awake craniotomy, surgery of gliomas, intraoperative neurophysiological testing, primary brain tumours, clinical experiences
Published in DiRROS: 25.07.2024; Views: 119; Downloads: 89
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3. Aberrantly expressed hsa_circ_0060762 and CSE1L as potential peripheral blood biomarkers for ALSMetka Ravnik-Glavač, Massimo Mezzavilla, Ana Dolinar, Blaž Koritnik, Damjan Glavač, 2023, original scientific article Abstract: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive adult-onset neurodegenerative disease that is often diagnosed with a delay due to initial non-specific symptoms. Therefore, reliable and easy-to-obtain biomarkers are an absolute necessity for earlier and more accurate diagnostics. Circular RNAs (circRNAs) have already been proposed as potential biomarkers for several neurodegenerative diseases. In this study, we further investigated the usefulness of circRNAs as potential biomarkers for ALS. We first performed a microarray analysis of circRNAs on peripheral blood mononuclear cells of a subset of ALS patients and controls. Among the differently expressed circRNA by microarray analysis, we selected only the ones with a host gene that harbors the highest level of conservation and genetic constraints. This selection was based on the hypothesis that genes under selective pressure and genetic constraints could have a major role in determining a trait or disease. Then we performed a linear regression between ALS cases and controls using each circRNA as a predictor variable. With a False Discovery Rate (FDR) threshold of 0.1, only six circRNAs passed the filtering and only one of them remained statistically significant after Bonferroni correction: hsa_circ_0060762 and its host gene CSE1L. Finally, we observed a significant difference in expression levels between larger sets of patients and healthy controls for both hsa_circ_0060762 and CSE1L. CSE1L is a member of the importin β family and mediates inhibition of TDP-43 aggregation; the central pathogenicity in ALS and hsa_circ_0060762 has binding sites for several miRNAs that have been already proposed as biomarkers for ALS. In addition, receiver operating characteristics curve analysis showed diagnostic potential for CSE1L and hsa_circ_0060762. Hsa_circ_0060762 and CSE1L thus represent novel potential peripheral blood biomarkers and therapeutic targets for ALS.
Keywords: amyotrophic lateral sclerosis, ALS, circRNA, biomarker, peripheral blood biomarker, hsa_circ_0060762, CSE1L, biomedicine
Published in DiRROS: 12.07.2024; Views: 110; Downloads: 118
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4. Temeljni pojmi in predlagano izrazoslovje v paliativni oskrbiMaja Ebert Moltara, Marjana Bernot, Jernej Benedik, Andrej Žist, Nena Golob, Stanislav Malačič, Maja Kolšek-Šušteršič, Maja Ivanetič Pantar, Blaž Koritnik, Anamarija Meglič, Nevenka Krčevski-Škvarč, 2020, professional monograph Abstract: Paliativna oskrba je v slovenskem prostoru mlada stroka. Z njenim razvojem so se začeli uporabljati številni izrazi, ki so včasih nejasno in nenatančno opredeljeni. Posledica tega je, tako med strokovnjaki kot na splošno v družbi, njeno neustrezno razumevanje. občasno zato prihaja do nesporazumov in posledično tudi do strokovnih napak. Namen izvajanja paliativne oskrbe je zagotoviti čim boljšo kakovost življenja bolnikom z napredujočimi neozdravljivimi boleznimi ter nuditi podporo njihovim bližnjim, v času bolnikove bolezni in po smrti. V paliativni oskrbi zdravstveno osebje veliko bolj kot sicer posveča pozornost celostni obravnavi posameznega človeka, kot osebo z individualnimi telesnimi, psihološkimi, socialnimi in duhovnimi potrebami. To je dinamičen proces, saj se moramo ves čas prilagajati trenutnim potrebam bolnika in njegovih bližnjih ter z aktivnim načrtovanjem učinkovito preprečevati nove in nepotrebne zaplete. Zgodnja paliativna oskrba se v začetku obravnave bolnika z neozdravljivo boleznijo prepleta s specifičnim zdravljenjem. Kasneje, z napredovanjem bolezni, obravnava prehaja v obdobje pozne paliativne oskrbe in obdobje oskrbe umirajočega. Po sodobnih smernicah se paliativna oskrba izvaja celostno, neprekinjeno in integrirano v ostale zdravstvene stroke. Cilj paliativne oskrbe je sledenje vrednotam posameznika in ohranjanje dostojanstva življenja. V prispevku smo zbrali najpogosteje uporabljene izraze s področja paliativne oskrbe. Na podlagi mednarodnih priporočil, lokalnih značilnosti in nacionalnih izkušenj smo jih skušali čim bolj jasno opredeliti za naš prostor. Natančno opredeljeni pojmi paliativne oskrbe in njihova dosledna uporaba bodo vodili k boljšemu medsebojnemu razumevanju strokovnjakov in uporabnikov paliativne oskrbe ter k njenemu kakovostnejšemu izvajanju.
Keywords: paliativna oskrba, zdravljenje, mesebojno sporazumevanje
Published in DiRROS: 04.01.2021; Views: 2136; Downloads: 542
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