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204. Spectral properties of Levy Rosenzweig-Porter model via supersymmetric approachElizaveta Safonova, Mikhail V. Feigel’man, Vladimir Kravtsov, 2025, original scientific article Abstract: By using the Efetov's super-symmetric formalism we computed analytically the mean spectral density ρ (E) for the Lévy and the Lévy -Rosenzweig-Porter random matrices which off-diagonal elements are strongly non-Gaussian with power-law tails. This makes the standard Hubbard-Stratonovich transformation inapplicable to such problems. We used, instead, the functional Hubbard-Stratonovich transformation which allowed to solve the problem analytically for large sizes of matrices. We show that ρ (E) depends crucially on the control parameter that drives the system through the transition between the ergodic and the fractal phases and it can be used as an order parameter.
Keywords: supersymmetry, random matrix theory, sigma models
Published in DiRROS: 05.12.2025; Views: 117; Downloads: 53
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206. Podatkovni arhiv dejavnosti Slovenskega kulturnega društva Lipa Zadar (2004–2024)Barbara Riman, Kristina Riman, 2025, complete scientific database of research data Abstract: Ta podatkovni set vsebuje strukturirane podatke, ki se nanašajo na dvajsetletno delovanje Slovenskega kulturnega društva Lipa Zadar (SKD Lipa Zadar). Podatki vključujejo informacije, zbrane v okviru priprave monografije, arhivskega dela društva ter analize društvene dejavnosti.
Podatkovni set je namenjen raziskovalcem, kulturnim institucijam, arhivistom, družboslovcem, etnologom in drugim, ki se ukvarjajo s področji: (1) kulturne dejavnosti v manjšinskih skupnostih, (2) slovenska manjšina na Hrvaškem, (3) društvena zgodovina, (4) migracijske in identitetne študije (5) primerjalne analize kulturnih društev.
Keywords: Slovensko društvo v Zadru, Slovenci na Hrvaškem, društva, zamejski Slovenci
Published in DiRROS: 05.12.2025; Views: 112; Downloads: 74
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207. Association of tumor-infiltrating lymphocytes and inflammation status with survival outcome in patients with high-grade serous ovarian carcinomaSimona Miceska, Cvetka Grašič-Kuhar, Snježana Frković-Grazio, Erik Škof, Praveen Krishnamoorthy, Dineo Khabele, Veronika Kloboves-Prevodnik, 2025, original scientific article Abstract: In this study, we investigated the association between tumor-infiltrating lymphocytes (TILs), inflammation status, and progression-free survival (PFS) in patients with primary high-grade serous ovarian carcinoma (HGSC). We assessed the percentages of different intraepithelial and stromal TIL subtypes using both manual and digital methods, following established recommendations for TIL assessment. In addition, we evaluated inflammation status through several immune scores, including the pan-immune-inflammation value (PIV). Our results suggest that stromal CD3+ and CD8+ TILs, as well as PIV, may serve as potential prognostic indicators in HGSC, as they remained potential independent markers in multivariate analysis.
Keywords: ovarian carcinoma, high-grade serous ovarian carcinoma, prognostic factors
Published in DiRROS: 05.12.2025; Views: 91; Downloads: 38
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208. Expression of inducible damage-associated molecular patterns after interleukin-12 gene electrotransfer in mouse melanoma and colorectal cell linesAjda Medved, Maša Omerzel, Tanja Jesenko, Simon Buček, Gregor Serša, Maja Čemažar, 2025, original scientific article Abstract: Interleukin-12 (IL-12) has demonstrated potent antitumor effects by activating natural killer (NK) and T cells, but its systemic administration poses challenges due to toxicity. This study investigated gene electrotransfer (GET) as a localized delivery method for IL-12 plasmids in B16F10 and CT26 tumor cells and its effect on the expression of damage-associated molecular patterns (DAMPs) and several cytokines. We observed the activation of cytosolic sensors and cytokine production, with the expression of IL-6 and TNF-α upregulated only after IL-12 GET, suggesting the involvement of inducible damage-associated molecular patterns (iDAMPs) in the immune response to IL-12 gene therapy. These findings highlight the multifaceted immune activation triggered by GET, offering insights for improving IL-12-based cancer therapies.
Keywords: gene electrotransfer, cytokine, interleukin-12
Published in DiRROS: 05.12.2025; Views: 136; Downloads: 38
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209. Patients’ daily reporting of symptoms via mobile application reveals a significant difference between patients’ perceptions and doctors’ interpretationsCvetka Grašič-Kuhar, Nina Privšek, Marjetka Sraka, Ema Grašič, Timotej Kovač, Matjaž Kukar, 2025, original scientific article Abstract: Electronic patient-reported outcomes (ePROs) are gaining importance. The aim of this study was to investigate the difference in the reporting of symptoms between patients via mobile application (m-app) and doctor assessments. Additionally, usability and satisfaction with the use of the m-app were assessed. Methods: In this single-center prospective cohort study, we analyzed ePROs in 46 patients receiving (neo)adjuvant chemotherapy for early breast cancer. Patients recorded the occurrence and intensity of symptoms via the Android-based m-app daily. Three-monthly, patients completed validated quality of life questionnaires (EORTC C30 and BR23). For the 10 most common symptoms reported by patients, we compared the frequencies and grades between patients and doctors. Additionally, we compared daily symptom reports with questionnaire results. Finally, the usefulness of and level of satisfaction with the m-app by patients and doctors were evaluated. Results: During the study, patients recorded almost twice as many different symptoms through the m-app as doctors did in the electronic health records (75 vs 49). Symptoms were described by patients as mild (67%), moderate (30%), or severe (3%). The frequency and intensity of symptoms reported by patients were significantly higher than those reported by doctors (p<0.001). Fatigue, insomnia and dry mouth were the three main symptoms reported in more than 75% of patients, but insomnia and dry mouth were also the symptoms most often underreported by doctors. After three months of chemotherapy, QoL assessments revealed worsening of physical, social, cognitive and role functioning, increased fatigue, systemic therapy side effects, and dyspnea but a reduction in arm and shoulder problems. Patients and doctors rated the m-app with an overall score of 4.5 out of 5 (IQR 1.0). Patients expressed high levels of satisfaction with and usability of the m-app. In contrast, doctors were somewhat reluctant to perceive ePROs as an additional burden with patient management. Conclusion: This study revealed a significant discrepancy between patients’ daily symptom reports via the m-app and doctors’ assessments, indicating that healthcare professionals may not fully capture patients’ experiences. This underscores the importance of integrating PROs to accurately evaluate patients’ conditions. Our m-app serves as a promising tool for reporting and managing side effects during systemic treatment of breast cancer.
Keywords: breast cancer, mobile application, patients, doctors
Published in DiRROS: 05.12.2025; Views: 99; Downloads: 41
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210. TransFactor—prediction of pro-viral SARS-CoV-2 host factors using a protein language modelYang An, Valter Bergant, Samuele Firmani, Corinna Grünke, Batiste Bonnal, Alexander Henrici, Andreas Pichlmair, Benjamin Schubert, Annalisa Marsico, 2025, original scientific article Published in DiRROS: 05.12.2025; Views: 108; Downloads: 56
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