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531 - 540 / 2000
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531.
532.
Structural fire behaviour
Felix Wiesner, Daniel Brandon, Andrea Lucherini, Pedro Palma, 2025, independent scientific component part or a chapter in a monograph

Abstract: Fire safety and fire protection objectives require that buildings and parts of buildings do not collapse during a fire. This requires that the load-carrying capacity is maintained to a minimum acceptable level during a fire. This chapter briefly describes the historical background and state of the art of fire resistance and its determination for timber members through testing or calculations. The thermal and mechanical principles that underpin structural behaviour of wood at elevated temperatures are explained in the context of explicit calculation methods that enable explicit evaluation of the structural capacity beyond fire resistance, which is a formalised and codified assessment of structural elements against a standard fire. The importance of connections to the overall structure in fire is explained along with suitable design considerations. Ultimately, knowledge gaps with respect to novel and more complex engineered timber products for taller timber buildings are highlighted alongside potential limitations of established design parameters.
Keywords: fire resistance, fire safety, structures, load-carrying capacity, timber, connections
Published in DiRROS: 18.11.2025; Views: 159; Downloads: 69
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Efficiency of vitamin D supplementation in healthy adults is associated with body mass index and baseline serum 25-hydroxyvitamin D level
Katja Žmitek, Maša Hribar, Hristo Hristov, Igor Pravst, 2020, original scientific article

Published in DiRROS: 18.11.2025; Views: 123; Downloads: 56
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537.
Comparative bioavailability of different coenzyme Q10 formulations in healthy elderly Individuals
Igor Pravst, Juan Carlos Rodríguez Aguilera, Ana Belen Cortes Rodriguez, Janja Jazbar, Igor Locatelli, Hristo Hristov, Katja Žmitek, 2020, original scientific article

Abstract: Coenzyme Q10 (CoQ10) plays a central role in mitochondrial oxidative phosphorylation. Several studies have shown the beneficial effects of dietary CoQ10 supplementation, particularly in relation to cardiovascular health. CoQ10 biosynthesis decreases in the elderly, and consequently, the beneficial effects of dietary supplementation in this population are of greater significance. However, most pharmacokinetic studies have been conducted on younger populations. The aim of this study was to investigate the single-dose bioavailability of different formulations of CoQ10 in a healthy geriatric population. A randomized, three-period, crossover bioavailability study was conducted on 21 healthy older adults (aged 65-74). The treatment was a single dose with a one-week washout period. Three different formulations containing the equivalent of 100 mg of CoQ10 were used: Q10Vital water-soluble CoQ10 syrup (the investigational product-IP); ubiquinol capsules (the comparative product-CP); and ubiquinone capsules (the standard product-SP). Ubiquinone/ubiquinol was followed in the plasma for 48 h. An analysis of the ratio of the area under the baseline-corrected concentration curve (deltaAUC48) for total CoQ10 and a comparison to SP yielded the following: The bioavailability of CoQ10 in the IP was 2.4-fold higher (95% CI: 1.3-4.5; p = 0.002), while the bioavailability of ubiquinol (CP) was not significantly increased (1.7-fold; 95% CI: 0.9%3.1, p = 0.129). No differences in the redox status of the absorbed coenzyme Q10 were observed between formulations, showing that CoQ10 appeared in the blood mostly as ubiquinol, even if consumed as ubiquinone.
Keywords: coenzyme Q10, CoQ10, Q10Vital, ubiquinone, ubiquinol, bioavailability, water-soluble formulations, the elderly
Published in DiRROS: 18.11.2025; Views: 151; Downloads: 72
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Emergency medical services utilisation among febrile children attending emergency departments across Europe : an observational multicentre study
Chantal D. Tan, Clementien L. Vermont, Joany M. Zachariasse, Ulrich Von Both, Irini Eleftheriou, Marieke Emonts, Michiel Van der Flier, Jethro Adam Herberg, Marko Pokorn, 2023, original scientific article

Abstract: Children constitute 6–10% of all patients attending the emergency department (ED) by emergency medical services (EMS). However, discordant EMS use in children occurs in 37–61% with fever as an important risk factor. We aimed to describe EMS utilisation among febrile children attending European EDs. This study is part of an observational multicentre study assessing management and outcome in febrile children up to 18 years (MOFICHE) attending twelve EDs in eight European countries. Discordant EMS use was defined as the absence of markers of urgency including intermediate/high triage urgency, advanced diagnostics, treatment, and admission in children transferred by EMS. Multivariable logistic regression analyses were performed for the association between (1) EMS use and markers of urgency, and (2) patient characteristics and discordant EMS use after adjusting all analyses for the covariates age, gender, visiting hours, presenting symptoms, and ED setting. A total of 5464 (15%, range 0.1–42%) children attended the ED by EMS. Markers of urgency were more frequently present in the EMS group compared with the non-EMS group. Discordant EMS use occurred in 1601 children (29%, range 1–59%). Age and gender were not associated with discordant EMS use, whereas neurological symptoms were associated with less discordant EMS use (aOR 0.2, 95%CI 0.1–0.2), and attendance out of office hours was associated with more discordant EMS use (aOR 1.6, 95%CI 1.4–1.9). Settings with higher percentage of self-referrals to the ED had more discordant EMS use (p < 0.05). Conclusion: There is large practice variation in EMS use in febrile children attending European EDs. Markers of urgency were more frequently present in children in the EMS group. However, discordant EMS use occurred in 29%. Further research is needed on non-medical factors influencing discordant EMS use in febrile children across Europe, so that pre-emptive strategies can be implemented.
Keywords: emergency medical services, emergency care, children, fever, paediatrics
Published in DiRROS: 17.11.2025; Views: 153; Downloads: 55
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