| Naslov: | Endoscopic management of patients with familial adenomatous polyposis after prophylactic colectomy or restorative proctocolectomy - systematic review of the literature |
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| Avtorji: | ID Gavrić, Aleksandar (Avtor)
ID Rivero-Sánchez, Liseth (Avtor)
ID Brunori, Angelo (Avtor)
ID Bravo, Raquel (Avtor)
ID Balaguer, Francesc (Avtor)
ID Pellisé, María (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (994,00 KB)
MD5: A4B5C0357C421D329E568BF50ECF3FF3
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.02 - Pregledni znanstveni članek |
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| Organizacija: |  DRO - Društvo radiologije in onkologije
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| Povzetek: | Background Patients with familial adenomatous polyposis (FAP) develop early colorectal adenomas and if left untreated, progression to cancer is an inevitable event. Prophylactic surgery does not prevent further development of cancer in the rectal remnant, rectal cuff in patients with ileal pouch anal anastomosis (IPAA) and even on the ileal mucosa of the pouch body. The aim of this review is to assess long-term rates of cancer and adenoma development in patients with FAP after prophylactic surgery and to summarise current recommendations for endoscopic management and surveillance of these patients. Materials and methods A systematic literature search of studies from January 1946 through to June 2023 was conducted using the PRISMA checklist. The electronic database PubMed was searched. Results Fifty-four papers involving 5010 patients were reviewed. Cancer rate in the rectal remnant was 8.8–16.7% in the western population and 37% in the eastern population. The cumulative risk of cancer 30 years after surgery was 24%. Mortality due to cancer in the rectal remnant is 1.1–11.1% with a 5-year survival rate of 55%. The adenoma rate after primary IPAA was 9.4–85% with a cumulative risk of 85% 20 years after surgery and a cumulative risk of 12% for advanced adenomas 10 years after surgery. Cumulative risk for adenomas after ileorectal anastomosis (IRA) was 85% after 5 and 100% after 10 years. Adenomas developed more frequently after stapled (33.9–57%) compared to hand-sewn (0–33%) anastomosis. We identified reports of 45 cancers in patients after IPAA of which 30 were in the pouch body and 15 in the rectal cuff or at the anastomosis. Conclusions There was a significant incidence of cancer and adenomas in the rectal remnant and ileal pouch of FAP patients during the long-term follow-up. Regular endoscopic surveillance is recommended, not only in IRA patients, but also in pouch patients after proctocolectom |
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| Ključne besede: | familial adenomatous polyposis, ileorectal anastomosis, ileal pouch-anal anastomosis |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 01.06.2024 |
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| Založnik: | Association of Radiology and Oncology |
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| Leto izida: | 2024 |
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| Št. strani: | str. 153-169, I |
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| Številčenje: | Vol. 58, no. 2 |
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| Izvor: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-30455  |
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| UDK: | 616-006 |
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| ISSN pri članku: | 1318-2099 |
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| DOI: | 10.2478/raon-2024-0029 |
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| COBISS.SI-ID: | 199294723 |
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| Datum objave v DiRROS: | 26.06.2026 |
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| Število ogledov: | 29 |
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| Število prenosov: | 16 |
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| Metapodatki: |    |
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