| Naslov: | Pathogenesis and potential reversibility of intestinal metaplasia − a milestone in gastric carcinogenesis |
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| Avtorji: | ID Drnovšek, Jan (Avtor)
ID Homan, Matjaž (Avtor)
ID Zidar, Nina (Avtor)
ID Šmid, Lojze (Avtor) |
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| Datoteke: |  URL - Izvorni URL, za dostop obiščite https://sciendo.com/article/10.2478/raon-2024-0028
 PDF - Predstavitvena datoteka, prenos (765,87 KB)
MD5: 236D1CD6CA183A3CAB63C4C75AF7F47C
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.02 - Pregledni znanstveni članek |
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| Organizacija: |  DRO - Društvo radiologije in onkologije
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| Povzetek: | Background. Non-cardia gastric cancer remains a major cause of cancer-related mortality worldwide, despite declining incidence rates in many industrialized countries. The development of intestinal-type gastric cancer occurs through a multistep process in which normal mucosa is sequentially transformed into hyperproliferative epithelium, followed by metaplastic processes leading to carcinogenesis. Chronic infection with Helicobacter pylori is the primary etiological agent that causes chronic inflammation of the gastric mucosa, induces atrophic gastritis, and can lead to intestinal metaplasia and dysplasia. Both intestinal metaplasia and dysplasia are precancerous lesions, in which gastric cancer is more likely to occur. Atrophic gastritis often improves after eradication of Helicobacter pylori; however, the occurrence of intestinal metaplasia has been traditionally regarded as “the point of no return” in the carcinogenesis sequence. Helicobacter pylori eradication heals non-atrophic chronic gastritis, may lead to regression of atrophic gastritis, and reduces the risk of gastric cancer in patients with these conditions. In this article, we discuss the pathogenesis, epigenomics, and reversibility of intestinal metaplasia and briefly touch upon potential treatment strategy. Conclusions. Gastric intestinal metaplasia no longer appears to be an irreversible precancerous lesion. However, there are still many controversies regarding the improvement of intestinal metaplasia after Helicobacter pylori eradication |
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| Ključne besede: | Helicobacter pylori, intestinal metaplasia, gastric cancer |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 01.06.2024 |
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| Založnik: | Association of Radiology and Oncology |
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| Leto izida: | 2024 |
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| Št. strani: | str. 186-195, III |
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| Številčenje: | Vol. 58, iss. 2 |
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| Izvor: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-30431  |
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| UDK: | 61 |
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| ISSN pri članku: | 1318-2099 |
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| DOI: | 10.2478/raon-2024-0028 |
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| COBISS.SI-ID: | 200321027 |
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| Opomba: | Soavtorji: Matjaž Homan, Nina Zidar, Lojze M Smid;
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| Datum objave v DiRROS: | 24.06.2026 |
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| Število ogledov: | 156 |
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| Število prenosov: | 127 |
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| Metapodatki: |    |
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