| Naslov: | Exploring early DNA methylation alterations in type 1 diabetes : implications of glycemic control |
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| Avtorji: | ID Čugalj Kern, Barbara (Avtor)
ID Kovač, Jernej (Avtor)
ID Šket, Robert (Avtor)
ID Tesovnik, Tine (Avtor)
ID Jenko Bizjan, Barbara (Avtor)
ID Galhardo, Julia (Avtor)
ID Battelino, Tadej (Avtor)
ID Bratina, Nataša (Avtor)
ID Dovč, Klemen (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (947,73 KB)
MD5: 563C28760D183341BB683F1C18A47FBD
 URL - Izvorni URL, za dostop obiščite https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1416433/full
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKC LJ - Univerzitetni klinični center Ljubljana
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| Povzetek: | Background: Prolonged hyperglycemia causes diabetes-related micro- and macrovascular complications, which combined represent a significant burden for individuals living with diabetes. The growing scope of evidence indicates that hyperglycemia affects the development of vascular complications through DNA methylation. Methods: A genome-wide differential DNA methylation analysis was performed on pooled peripheral blood DNA samples from individuals with type 1 diabetes (T1D) with direct DNA sequencing. Strict selection criteria were used to ensure two age- and sex-matched groups with no clinical signs of chronic complications according to persistent mean glycated hemoglobin (HbA1c) values over 5 years: HbA1c<7% (N=10) and HbA1c>8% (N=10). Results: Between the two groups, 8385 differentially methylated CpG sites, annotated to 1802 genes, were identified. Genes annotated to hypomethylated CpG sites were enriched in 48 signaling pathways. Further analysis of key CpG sites revealed four specific regions, two of which were hypermethylated and two hypomethylated, associated with long non-coding RNA and processed pseudogenes. Conclusions: Prolonged hyperglycemia in individuals with T1D, who have no clinical manifestation of diabetes-related complications, is associated with multiple differentially methylated CpG sites in crucial genes and pathways known to be linked to chronic complications in T1D |
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| Ključne besede: | type 1 diabetes, glycemic control, DNA methylation, diabetes-related complications, long-read sequencing |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Leto izida: | 2024 |
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| Št. strani: | str. 1-10 |
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| Številčenje: | Vol. 15 |
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| PID: | 20.500.12556/DiRROS-29845  |
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| UDK: | 61 |
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| ISSN pri članku: | 1664-2392 |
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| DOI: | 10.3389/fendo.2024.1416433 |
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| COBISS.SI-ID: | 198843395 |
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| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne 13. 6. 2024;
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| Datum objave v DiRROS: | 08.06.2026 |
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| Število ogledov: | 104 |
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| Število prenosov: | 66 |
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| Metapodatki: |    |
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