| Naslov: | Effect of antioxidant-rich kindergarten meals on oxidative stress biomarkers in healthy 5-6-year-old children : a randomized controlled trial |
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| Avtorji: | ID Berlic, Maja (Avtor)
ID Korošec, Mojca (Avtor)
ID Remec, Žiga Iztok (Avtor)
ID Čuk, Vanja (Avtor)
ID Battelino, Tadej (Avtor)
ID Repič-Lampret, Barbka (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (1,03 MB)
MD5: F3489832DF3F35FEF428C845F4D3660A
 URL - Izvorni URL, za dostop obiščite https://link.springer.com/article/10.1007/s00431-024-05576-6
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKC LJ - Univerzitetni klinični center Ljubljana
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| Povzetek: | As children spend up to 9 h a day in kindergarten, the main purpose of our study was to evaluate the effect of antioxidant-rich kindergarten meals on oxidative stress biomarkers (OSBs) in healthy children. In the randomized control trial with a follow-up, healthy 5–6-year-old children from six kindergartens were randomly divided into a prototype group (PG, n=40) and a control group (CG, n=17). PG followed a 2-week antioxidant-rich kindergarten meal plan (breakfast, lunch, and two snacks), and CG followed their standard kindergarten meal plans. Outside the kindergartens, participants ate as usual. We used a consecutive 7-day dietary record inside and outside the kindergarten and the national dietary assessment tool OPEN to assess the total dietary antioxidant capacity (dTAC) of the consumed foods. Malondialdehyde (MDA), 8-hydroxy-2-deoxyguanosine (8-OHdG), and four F2-isoprostane were measured in fasting urine on days 1 and 15. We also measured total antioxidant power (PAT) and hydroperoxides (d-ROMs) in fasting serum on day 15 and obtained the value of the oxidative stress index (OSI). We used a Welch two-sample t-test and multiple regression analysis to compare the prototype and control groups and a nonparametric Wilcoxon signed rank exact test to compare pre- and post-intervention results in urine. Antioxidant-rich kindergarten meals contributed to a significantly (p<0.05) higher intake of dTAC in PG participants compared to standard meals in CG participants (8.6 vs. 2.8 mmol/day). We detected a negative correlation between dTAC intake and d-ROMs and between dTAC intake and OSI (r= −0.29, p=0.043 and r= −0.31, p=0.032, respectively). A significant decrease in urinary 8-iso-15-prostaglandin-F-2 alpha was detected in PG participants between days 1 and 15; however, no other intra-individual significant differences in urinary OSBs were found. |
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| Ključne besede: | antioxidant-rich diet, oxidative stress biomarkers, dietary antioxidant capacity, reactive oxygen metabolites, F2-isoprostanes, kindergarten diet |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Leto izida: | 2024 |
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| Št. strani: | str. 3085-3094 |
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| Številčenje: | Vol. 183, issue 7 |
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| PID: | 20.500.12556/DiRROS-29836  |
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| UDK: | 613.2-053.2:641.1 |
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| ISSN pri članku: | 0340-6199 |
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| DOI: | 10.1007/s00431-024-05576-6 |
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| COBISS.SI-ID: | 197529347 |
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| Opomba: |
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| Datum objave v DiRROS: | 08.06.2026 |
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| Število ogledov: | 66 |
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| Število prenosov: | 36 |
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| Metapodatki: |    |
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