| Naslov: | Clinical care advice for monitoring of islet autoantibody positive individuals with presymptomatic type 1 diabetes |
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| Avtorji: | ID Hendriks, A. Emile J. (Avtor)
ID Marcovecchio, M. Loredana (Avtor)
ID Besser, Rachel E.J. (Avtor)
ID Bonifacio, Ezio (Avtor)
ID Casteels, Kristina (Avtor)
ID Elding Larsson, Helena (Avtor)
ID Gemulla, Gita (Avtor)
ID Lundgren, Markus (Avtor)
ID Kordonouri, Olga (Avtor)
ID Mallone, Roberto (Avtor)
ID Battelino, Tadej (Sodelavec pri raziskavi), et al. |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (942,25 KB)
MD5: D03BA67159CD0E895D6ECEE0FE974305
 URL - Izvorni URL, za dostop obiščite https://onlinelibrary.wiley.com/doi/epdf/10.1002/dmrr.3777
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKC LJ - Univerzitetni klinični center Ljubljana
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| Povzetek: | Type 1 diabetes is an autoimmune disease that involves the development of autoantibodies against pancreatic islet beta-cell antigens, preceding clinical diagnosis by a period of preclinical disease activity. As screening activity to identify autoantibody-positive individuals increases, a rise in presymptomatic type 1 diabetes individuals seeking medical attention is expected. Current guidance on how to monitor these individuals in a safe but minimally invasive way is limited. This article aims to provide clinical guidance for monitoring individuals with presymptomatic type 1 diabetes to reduce the risk of diabetic ketoacidosis (DKA) at diagnosis. Expert consensus was obtained from members of the Fr1da, GPPAD, and INNODIA consortia, three European diabetes research groups. The guidance covers both specialist and primary care follow-up strategies. The guidance outlines recommended monitoring approaches based on age, disease stage and clinical setting. Individuals with presymptomatic type 1 diabetes are best followed up in specialist care. For stage 1, biannual assessments of random plasma glucose and HbA1c are suggested for children, while annual assessments are recommended for adolescents and adults. For stage 2, 3-monthly clinic visits with additional home monitoring are advised. The value of repeat OGTT in stage 1 and the use of continuous glucose monitoring in stage 2 are discussed. Primary care is encouraged to monitor individuals who decline specialist care, following the guidance presented. As type 1 diabetes screening programs become more prevalent, effective monitoring strategies are essential to mitigate the risk of complications such as DKA. This guidance serves as a valuable resource for clinicians, providing practical recommendations tailored to an individual's age and disease stage, both within specialist and primary care settings. |
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| Ključne besede: | type 1 diabetes, presymptomatic type 1 diabetes, diabetic ketoacidosis, guidance |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Leto izida: | 2024 |
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| Št. strani: | str. 1-10 |
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| Številčenje: | Vol. 40, iss. 2, ǂ[article no.] ǂe3777 |
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| PID: | 20.500.12556/DiRROS-29795  |
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| UDK: | 616.379 |
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| ISSN pri članku: | 1099-0895 |
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| DOI: | 10.1002/dmrr.3777 |
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| COBISS.SI-ID: | 199142915 |
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| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne 17. 6. 2024;
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| Datum objave v DiRROS: | 05.06.2026 |
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| Število ogledov: | 55 |
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| Število prenosov: | 42 |
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| Metapodatki: |    |
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