| Naslov: | Long-term follow-up of 109 children with juvenile idiopathic oligoarthritis after first intra-articular corticosteroid injection |
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| Avtorji: | ID Zajc Avramovič, Mojca (Avtor)
ID Toplak, Nataša (Avtor)
ID Markelj, Gašper (Avtor)
ID Emeršič, Nina (Avtor)
ID Avčin, Tadej (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (1,47 MB)
MD5: CF98A4913B81A84B886316486EBB8FC2
 URL - Izvorni URL, za dostop obiščite https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-024-03303-y
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKC LJ - Univerzitetni klinični center Ljubljana
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| Povzetek: | Background: To evaluate long-term outcomes and prognostic factors in patients with juvenile idiopathic arthritis (JIA), presenting as oligoarthritis, who received IAC as the first treatment for their disease. Methods: We conducted retrospective study at the University Children's Hospital Ljubljana, Slovenia, from January 2015 to May 2023 in children with JIA, clinically presenting as oligoarthritis receiving intra-articular corticosteroid injection (IAC) as the initial treatment. Patient and treatment data were collected, and the outcomes were categorized into three groups based on the later need for therapy: no therapy needed, only additional IAC needed and systemic therapy needed. The last group was further divided based on the requirement of bDMARD. Log-rank (Mantel-Cox) survival analyses compared different outcome groups. Results: We included 109 patients with JIA, presenting as oligoarthritis (63% female), who were first treated with IAC. The mean age at IAC was 8.0 years, with a 4.3-year follow-up. Notably, 38.5% of patients did not require additional therapy post-IAC, whereas 15.5% required only additional IAC. Systemic therapy, mainly methotrexate (MTX), was necessary for 45.9% of patients, initiated in average 7.8 months post-IAC. Biologic therapy was initiated in 22% in average 2.2 years post-IAC. Number of injected joints correlated with the need for biologics. At the last follow-up, 88.9% had inactive disease. ANA positivity (P = 0.049, chi square 3.89) and HLA B27 antigen presence (P = 0.050, chi square 3.85) were associated with the need for systemic therapy. A subgroup of children older than 8 years, ANA and HLA B27 negative required significantly less systemic (25.8%) and biologic therapy (9.6%) compared to other patients (p = 0.050, chi square 3.77). Conclusion: Almost 40% of children with oligoarticular JIA requiring IAC did not progress to chronic disease. Younger age, ANA positivity, and HLA B27 presence were predictive factors for systemic therapy, while the number of injected joints predicted the future need for biologic therapy |
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| Ključne besede: | ANA, biologic therapy, HLA B27, juvenile idiopathic arthitis, long-term follow-up, methotrexate, oligoarthritis, outcome, pediatric arthritis |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Leto izida: | 2024 |
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| Št. strani: | str. 1-9 |
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| Številčenje: | Vol. 26, iss. 1, [article no.] 69 |
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| PID: | 20.500.12556/DiRROS-29733  |
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| UDK: | 61 |
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| ISSN pri članku: | 1478-6362 |
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| DOI: | 10.1186/s13075-024-03303-y |
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| COBISS.SI-ID: | 203656707 |
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| Opomba: |
Nasl z nasl. zaslona;
Opis vira z dne 5. 8. 2024;
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| Datum objave v DiRROS: | 04.06.2026 |
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| Število ogledov: | 51 |
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| Število prenosov: | 36 |
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| Metapodatki: |    |
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